Small-molecule WNK inhibition regulates cardiovascular and renal function
Yamada, Ken, Park, Hyi-Man, Rigel, Dean F, DiPetrillo, Keith, Whalen, Erin J, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara Emily, Burdick, Debra A, Caplan, Shari L, Capparelli, Michael P, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waan-Jeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar K, Kohls, Darcy, Kunjathoor, Vidya, LaSala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal J, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka H, Trakshel, Gary M, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer B, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko I, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji-Hu, Zheng, Gang, Monovich, Lauren
Published in Nature chemical biology (01.11.2016)
Published in Nature chemical biology (01.11.2016)
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Discovery and Characterization of Allosteric WNK Kinase Inhibitors
Yamada, Ken, Zhang, Ji-Hu, Xie, Xiaoling, Reinhardt, Juergen, Xie, Amy Qiongshu, LaSala, Daniel, Kohls, Darcy, Yowe, David, Burdick, Debra, Yoshisue, Hajime, Wakai, Hiromichi, Schmidt, Isabel, Gunawan, Jason, Yasoshima, Kayo, Yue, Q. Kimberley, Kato, Mitsunori, Mogi, Muneto, Idamakanti, Neeraja, Kreder, Natasha, Drueckes, Peter, Pandey, Pramod, Kawanami, Toshio, Huang, Waanjeng, Yagi, Yukiko I, Deng, Zhan, Park, Hyi-Man
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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PhototoxicityMedicinal Chemistry Strategies for Risk Mitigation in Drug Discovery
Harrison, Tyler J., Chen, Xin, Yasoshima, Kayo, Bauer, Daniel
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Benzimidazole-5-sulfonamides as Novel Nonpeptide Luteinizing Hormone Releasing Hormone (LHRH) Antagonists: Minimization of Mechanism-Based CYP3A4 Inhibition
Hashimoto, Kentaro, Kataoka, Mikayo, Tatsuta, Miyuki, Yasoshima, Kayo, Yamamoto, Mako, Yura, Takeshi, Yamamoto, Noriyuki, Urbahns, Klaus, Gupta, Jang Bahadur, Li, Yingfu
Published in Chemical & Pharmaceutical Bulletin (2005)
Published in Chemical & Pharmaceutical Bulletin (2005)
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Journal Article
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models
Yamada, Ken, Levell, Julian, Yoon, Taeyong, Kohls, Darcy, Yowe, David, Rigel, Dean F, Imase, Hidetomo, Yuan, Jun, Yasoshima, Kayo, DiPetrillo, Keith, Monovich, Lauren, Xu, Lingfei, Zhu, Meicheng, Kato, Mitsunori, Jain, Monish, Idamakanti, Neeraja, Taslimi, Paul, Kawanami, Toshio, Argikar, Upendra A, Kunjathoor, Vidya, Xie, Xiaoling, Yagi, Yukiko I, Iwaki, Yuki, Robinson, Zachary, Park, Hyi-Man
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma
Yamada, Ken, Brousseau, Margaret, Honma, Wataru, Iimura, Akiko, Imase, Hidetomo, Iwaki, Yuki, Kawanami, Toshio, LaSala, Daniel, Liang, Guiqing, Mitani, Hironobu, Nonomura, Kazuhiko, Ohmori, Osamu, Pan, Meihui, Rigel, Dean F, Umemura, Ichiro, Yasoshima, Kayo, Zhu, Guoming, Mogi, Muneto
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity
Brown, Alan P, Saravanan, Chandrassegar, Devine, Patrick, Magnifico, Maria, Gao, Jiaping, Beaulieu, Valerie, Ma, Fupeng, Yasoshima, Kayo, Barnes-Seeman, David, Yamada, Ken
Published in International journal of toxicology (01.07.2017)
Published in International journal of toxicology (01.07.2017)
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Tetrahydro-naphthols as orally available TRPV1 inhibitors
Urbahns, Klaus, Yura, Takeshi, Gupta, Jang B., Tajimi, Masaomi, Fujishima, Hiroshi, Masuda, Tsutomu, Yamamoto, Noriyuki, Ikegami, Yuka, Marumo, Makiko, Yasoshima, Kayo, Yoshida, Nagahiro, Moriwaki, Toshiya, Madge, David, Chan, Fiona, Mogi, Muneto
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1 H-benzimidazol-5-yl)-3- tert-butylurea derivatives
Tatsuta, Miyuki, Kataoka, Mikayo, Yasoshima, Kayo, Sakakibara, Sachiko, Shogase, Yuka, Shimazaki, Makoto, Yura, Takeshi, Li, Yingfu, Yamamoto, Noriyuki, Gupta, Jang, Urbahns, Klaus
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 2: Benzimidazole-5-sulfonamides
Li, Yingfu, Kataoka, Mikayo, Tatsuta, Miyuki, Yasoshima, Kayo, Yura, Takeshi, Urbahns, Klaus, Kiba, Atsushi, Yamamoto, Noriyuki, Gupta, Jang B., Hashimoto, Kentaro
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides
Hashimoto, Kentaro, Tatsuta, Miyuki, Kataoka, Mikayo, Yasoshima, Kayo, Shogase, Yuka, Shimazaki, Makoto, Yura, Takeshi, Li, Yingfu, Yamamoto, Noriyuki, Gupta, Jang B., Urbahns, Klaus
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Corrigendum to “Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1 H-benzimidazol-5-yl)-3- tert-butylurea derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 2265]
Tatsuta, Miyuki, Kataoka, Mikayo, Yasoshima, Kayo, Sakakibara, Sachiko, Shogase, Yaka, Shimazaki, Makoto, Yura, Takeshi, Li, Yingfu, Yamamoto, Noriyuki, Gupta, Jang, Urbahns, Klaus
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
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Benzimidazole-5-sulfonamides as Novel Nonpeptide Luteinizing Hormone Releasing Hormone (LHRH) Antagonists
Hashimoto, Kentaro, Kataoka, Mikayo, Tatsuta, Miyuki, Yasoshima, Kayo, Yamamoto, Mako, Yura, Takeshi, Yamamoto, Noriyuki, Urbahns, Klaus, Bahadur Gupta, Jang, Li, Yingfu
Published in Chemical & pharmaceutical bulletin (01.10.2005)
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Published in Chemical & pharmaceutical bulletin (01.10.2005)
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SYNTHETIC LINEAR APELIN MIMETICS FOR THE TREATMENT OF HEART FAILURE
YUAN, Jun, ZHAO, Hongjuan, YASOSHIMA, Kayo, ZECRI, Frédéric, GROSCHE, Philipp
Year of Publication 10.10.2018
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Year of Publication 10.10.2018
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NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA
GULGEZE EFTHYMIOU, Hatice Belgin, SMITH, Nichola, BARBE, Guillaume, GENG, Sicong, YAMADA, Ken, BEBERNITZ, Gregory Raymond, MA, Fupeng, YASOSHIMA, Kayo, PARKER, David Thomas, PENG, Yunshan, LIAO, Lv, MO, Ruowei, PEUKERT, Stefan
Year of Publication 01.03.2023
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Year of Publication 01.03.2023
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