Search Results - "KAWASUJI TAKASHI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection

Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection

by Yoshinaga, Tomokazu, Kobayashi, Masanori, Seki, Takahiro, Miki, Shigeru, Wakasa-Morimoto, Chiaki, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A, Underwood, Mark R, Garvey, Edward P, Sato, Akihiko, Fujiwara, Tamio
Published in Antimicrobial agents and chemotherapy (01.01.2015)

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Journal Article

Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics

Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics

by DeAnda, Felix, Hightower, Kendra E, Nolte, Robert T, Hattori, Kazunari, Yoshinaga, Tomokazu, Kawasuji, Takashi, Underwood, Mark R
Published in PloS one (16.10.2013)

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Journal Article

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

by Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Taishi, Teruhiko, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Fujiwara, Tamio
Published in Journal of medicinal chemistry (25.10.2012)

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Journal Article

POLYCYCLIC PYRIDOPYRAZINE DERIVATIVE

POLYCYCLIC PYRIDOPYRAZINE DERIVATIVE

by KAWASUJI Takashi, TOMIDA Yutaka
Year of Publication 03.06.2021

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Patent

Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond

Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond

by Sugiyama, Shuichi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Iwaki, Tsutomu, Matsuoka, Eriko, Akihisa, Erika, Seki, Takahiro, Yoshinaga, Tomokazu, Kawasuji, Takashi
Published in Bioorganic & medicinal chemistry letters (01.02.2021)

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Journal Article

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

by Johns, Brian A, Kawasuji, Takashi, Weatherhead, Jason G, Taishi, Teruhiko, Temelkoff, David P, Yoshida, Hiroshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Jeffrey, Jerry, Foster, Scott A, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Johnson, Matthew N, Garvey, Edward P, Fujiwara, Tamio
Published in Journal of medicinal chemistry (25.07.2013)

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Journal Article

Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors

Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors

by Akiyama, Toshiyuki, Johns, Brian A., Taoda, Yoshiyuki, Yoshida, Hiroshi, Taishi, Teruhiko, Kawasuji, Takashi, Murai, Hitoshi, Yoshinaga, Tomokazu, Sato, Akihiko, Seki, Takahiro, Koyama, Mikiko, Miki, Shigeru, Kawauchi-Miki, Shinobu, Kagitani-Suyama, Akemi, Fujiwara, Tamio
Published in Bioorganic & medicinal chemistry letters (01.10.2024)

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Journal Article

Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold

Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold

by Sugiyama, Shuichi, Iwaki, Tsutomu, Tamura, Yoshinori, Tomita, Kenji, Matsuoka, Eriko, Arita, Shuhei, Seki, Takahiro, Yoshinaga, Tomokazu, Kawasuji, Takashi
Published in Bioorganic & medicinal chemistry (01.09.2020)

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Journal Article

Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction

Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction

by Taoda, Yoshiyuki, Akiyama, Toshiyuki, Tomita, Kenji, Fujiwara-Kitamura, Misato, Tamura, Yoshinori, Kawasuji, Takashi, Matsuoka, Eriko, Akihisa, Erika, Seki, Takahiro, Yoshinaga, Tomokazu
Published in Bioorganic & medicinal chemistry letters (15.05.2022)

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Journal Article

Enantioselective syntheses of d- erythro-sphingosine and phytosphingosine from simple achiral aldehydes using catalytic asymmetric aldol reactions as key steps

Enantioselective syntheses of d- erythro-sphingosine and phytosphingosine from simple achiral aldehydes using catalytic asymmetric aldol reactions as key steps

by Kobayashi, Shū, Hayashi, Takaomi, Kawasuji, Takashi
Published in Tetrahedron letters (19.12.1994)

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Journal Article

1,2-Asymmetric induction in the SN2'-allylation of organocopper and organozinc reagents

1,2-Asymmetric induction in the SN2'-allylation of organocopper and organozinc reagents

by Arai, Masayuki, Kawasuji, Takashi, Nakamura, Eiichi
Published in Journal of organic chemistry (01.09.1993)

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Journal Article

A NEW SYNTHETIC ROUTE TO MONOSACCHARIDES FROM SIMPLE ACHIRAL COMPOUNDS BY USING A CATALYTIC ASYMMETRIC ALDOL REACTION AS A KEY STEP

A NEW SYNTHETIC ROUTE TO MONOSACCHARIDES FROM SIMPLE ACHIRAL COMPOUNDS BY USING A CATALYTIC ASYMMETRIC ALDOL REACTION AS A KEY STEP

by KOBAYASHI, S, KAWASUJI, T
Published in Synlett (1993)

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Journal Article

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

by Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Weatherhead, Jason G, Akiyama, Toshiyuki, Taishi, Teruhiko, Taoda, Yoshiyuki, Mikamiyama-Iwata, Minako, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Garvey, Edward P, Fujiwara, Tamio
Published in Journal of medicinal chemistry (14.02.2013)

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Journal Article

3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

by Kawasuji, Takashi, Fuji, Masahiro, Yoshinaga, Tomokazu, Sato, Akihiko, Fujiwara, Tamio, Kiyama, Ryuichi
Published in Bioorganic & medicinal chemistry (15.08.2007)

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Journal Article

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

by Kawasuji, Takashi, Fuji, Masahiro, Yoshinaga, Tomokazu, Sato, Akihiko, Fujiwara, Tamio, Kiyama, Ryuichi
Published in Bioorganic & medicinal chemistry (15.12.2006)

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Journal Article

A NOVEL CHIRAL CATALYST SYSTEM, TIN(II) TRIFLATE, A CHIRAL DIAMINE, AND TIN(II) OXIDE, IN ASYMMETRIC ALDOL REACTIONS

A NOVEL CHIRAL CATALYST SYSTEM, TIN(II) TRIFLATE, A CHIRAL DIAMINE, AND TIN(II) OXIDE, IN ASYMMETRIC ALDOL REACTIONS

by KOBAYASHI, S, KAWASUJI, T, MORI, N
Published in Chemistry letters (01.02.1994)

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Journal Article

Synthesis and Evaluation of 7-Substituted 4-Aminoquinoline Analogues for Antimalarial Activity

Synthesis and Evaluation of 7-Substituted 4-Aminoquinoline Analogues for Antimalarial Activity

by Hwang, Jong Yeon, Kawasuji, Takashi, Lowes, David J, Clark, Julie A, Connelly, Michele C, Zhu, Fangyi, Guiguemde, W. Armand, Sigal, Martina S, Wilson, Emily B, DeRisi, Joseph L, Guy, R. Kiplin
Published in Journal of medicinal chemistry (27.10.2011)

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Journal Article

NITROGEN-CONTAINING TRICYCLIC DERIVATIVE HAVING HIV DUPLICATION INHIBITORY EFFECT

NITROGEN-CONTAINING TRICYCLIC DERIVATIVE HAVING HIV DUPLICATION INHIBITORY EFFECT

by SUGIYAMA SHUICHI, MATSUMURA AKIRA, KAWASUJI TAKASHI, TAMURA YOSHINORI, AKIYAMA TOSHIYUKI, TOMITA YUTAKA
Year of Publication 25.06.2020

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Patent

A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

by Kawasuji, Takashi, Yoshinaga, Tomokazu, Sato, Akihiko, Yodo, Mitsuaki, Fujiwara, Tamio, Kiyama, Ryuichi
Published in Bioorganic & medicinal chemistry (15.12.2006)

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Journal Article

Naphthyridinone (NTD) integrase inhibitors: N1 Protio and methyl combination substituent effects with C3 amide groups

Naphthyridinone (NTD) integrase inhibitors: N1 Protio and methyl combination substituent effects with C3 amide groups

by Johns, Brian A., Kawasuji, Takashi, Weatherhead, Jason G., Boros, Eric E., Thompson, James B., Koble, Cecilia S., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Fujiwara, Tamio
Published in Bioorganic & medicinal chemistry letters (15.01.2013)

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