Comparing In Vitro and In Vivo Activity of 2′-O-[2-(Methylamino)-2-oxoethyl]- and 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides
Prakash, Thazha P, Kawasaki, Andrew M, Wancewicz, Edward V, Shen, Lijiang, Monia, Brett P, Ross, Bruce S, Bhat, Balkrishen, Manoharan, Muthiah
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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2‘-O-[2-(Amino)-2-oxoethyl] Oligonucleotides
Prakash, Thazha P, Kawasaki, Andrew M, Lesnik, Elena A, Owens, Stephen R, Manoharan, Muthiah
Published in Organic letters (20.02.2003)
Published in Organic letters (20.02.2003)
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Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets
Kawasaki, Andrew M, Casper, Martin D, Freier, Susan M, Lesnik, Elena A, Zounes, Maryann C, Cummins, Lendell L, Gonzalez, Carolyn, Cook, P. Dan
Published in Journal of medicinal chemistry (02.04.1993)
Published in Journal of medicinal chemistry (02.04.1993)
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2‘-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2‘-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Prakash, Thazha P, Manoharan, Muthiah, Kawasaki, Andrew M, Fraser, Allister S, Lesnik, Elena A, Sioufi, Namir, Leeds, Janet M, Teplova, Marianna, Egli, Martin
Published in Biochemistry (Easton) (01.10.2002)
Published in Biochemistry (Easton) (01.10.2002)
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Synthesis of 2′- O-[2-[( N, N-dialkylamino)oxy]ethyl]-modified oligonucleotides: hybridization affinity, resistance to nuclease, and protein binding characteristics
Prakash, Thazha P, Kawasaki, Andrew M, Lesnik, Elena A, Sioufi, Namir, Manoharan, Muthiah
Published in Tetrahedron (08.09.2003)
Published in Tetrahedron (08.09.2003)
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Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes
Lesnik, Elena A, Guinosso, Charles J, Kawasaki, Andrew M, Sasmor, Henri, Zounes, Maryann, Cummins, Lendell L, Ecker, David J, Cook, P. Dan, Freier, Susan M
Published in Biochemistry (Easton) (03.08.1993)
Published in Biochemistry (Easton) (03.08.1993)
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2‘-O-{2-[N,N-(Dialkyl)aminooxy]ethyl}- Modified Antisense Oligonucleotides
Prakash, Thazha P, Manoharan, Muthiah, Kawasaki, Andrew M, Lesnik, Elena A, Owens, Stephen R, Vasquez, Guillermo
Published in Organic letters (14.12.2000)
Published in Organic letters (14.12.2000)
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Design and synthesis of new tricyclic indoles as potent modulators of the S1P(1) receptor
Buzard, Daniel J., Schrader, Thomas O., Zhu, Xiuwen, Lehmann, Juerg, Johnson, Ben, Kasem, Michelle, Kim, Sun Hee, Kawasaki, Andrew, Lopez, Luis, Moody, Jeanne, Han, Sangdon, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Gatlin, Joel, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor
Buzard, Daniel J., Schrader, Thomas O., Zhu, Xiuwen, Lehmann, Juerg, Johnson, Ben, Kasem, Michelle, Kim, Sun Hee, Kawasaki, Andrew, Lopez, Luis, Moody, Jeanne, Han, Sangdon, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Gatlin, Joel, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor
Buzard, Daniel J, Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Montalban, Antonio Garrido, Ma, You-An, Sage, Carleton, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Chen, Weichao, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Mills, David, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Gaidarov, Ibragim, Anthony, Todd, Unett, David J, Blackburn, Anthony, Rueter, Jaimie, Stirn, Scott, Behan, Dominic P, Jones, Robert M
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Design and synthesis of new tricyclic indoles as potent modulators of the S1P sub(1) receptor
Buzard, Daniel J, Schrader, Thomas O, Zhu, Xiuwen, Lehmann, Juerg, Johnson, Ben, Kasem, Michelle, Kim, Sun Hee, Kawasaki, Andrew, Lopez, Luis, Moody, Jeanne, Han, Sangdon, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Gatlin, Joel, Jones, Robert M
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series
Han, Sangdon, Narayanan, Sanju, Kim, Sun Hee, Calderon, Imelda, Zhu, Xiuwen, Kawasaki, Andrew, Yue, Dawei, Lehmann, Juerg, Wong, Amy, Buzard, Daniel J., Semple, Graeme, Carroll, Chris, Chu, Zhi-Liang, Al-Sharmma, Hussein, Shu, Hsin-Hui, Tung, Shiu-Feng, Unett, David J., Behan, Dominic P., Yoon, Woo Hyun, Morgan, Michael, Usmani, Khawja A., Chen, Chuan, Sadeque, Abu, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
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Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists
Buzard, Daniel J., Kim, Sun Hee, Lehmann, Juerg, Han, Sangdon, Calderon, Imelda, Wong, Amy, Kawasaki, Andrew, Narayanan, Sanju, Bhat, Rohit, Gharbaoui, Tawfik, Lopez, Luis, Yue, Dawei, Whelan, Kevin, Al-Shamma, Hussien, Unett, David J., Shu, Hsin-Hui, Tung, Shiu-Feng, Chang, Steve, Chuang, Ching-Fen, Morgan, Michael, Sadeque, Abu, Chu, Zhi-Liang, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs
Kawasaki, Andrew M, Knapp, Richard J, Kramer, Thomas H, Walton, Amanda, Wire, William S, Hashimoto, Shinicki, Yamamura, Henry I, Porreca, Frank, Burks, Thomas F, Hruby, Victor J
Published in Journal of medicinal chemistry (19.03.1993)
Published in Journal of medicinal chemistry (19.03.1993)
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(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists
Buzard, Daniel J, Lopez, Luis, Moody, Jeanne, Kawasaki, Andrew, Schrader, Thomas O, Kasem, Michelle, Johnson, Ben, Zhu, Xiuwen, Thoresen, Lars, Kim, Sun Hee, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Krishnan, Ashwin, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Chen, Weichao, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Gaidarov, Ibragim, Anthony, Todd, Le, Minh, Unett, David J, Stirn, Scott, Blackburn, Anthony, Behan, Dominic P, Jones, Robert M
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Journal Article
Design and synthesis of highly potent and selective cyclic dynorphin A analogs
Kawasaki, Andrew M, Knapp, Richard J, Kramer, Thomas H, Wire, William S, Vasquez, Olga S, Yamamura, Henry I, Burks, Thomas F, Hruby, Victor J
Published in Journal of medicinal chemistry (01.07.1990)
Published in Journal of medicinal chemistry (01.07.1990)
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Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P 1 agonists
Buzard, Daniel, Han, Sangdon, Thoresen, Lars, Moody, Jeanne, Lopez, Luis, Kawasaki, Andrew, Schrader, Thomas, Sage, Carleton, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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