Comparing In Vitro and In Vivo Activity of 2′-O-[2-(Methylamino)-2-oxoethyl]- and 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides
Prakash, Thazha P, Kawasaki, Andrew M, Wancewicz, Edward V, Shen, Lijiang, Monia, Brett P, Ross, Bruce S, Bhat, Balkrishen, Manoharan, Muthiah
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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2‘-O-[2-(Amino)-2-oxoethyl] Oligonucleotides
Prakash, Thazha P, Kawasaki, Andrew M, Lesnik, Elena A, Owens, Stephen R, Manoharan, Muthiah
Published in Organic letters (20.02.2003)
Published in Organic letters (20.02.2003)
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Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets
Kawasaki, Andrew M, Casper, Martin D, Freier, Susan M, Lesnik, Elena A, Zounes, Maryann C, Cummins, Lendell L, Gonzalez, Carolyn, Cook, P. Dan
Published in Journal of medicinal chemistry (02.04.1993)
Published in Journal of medicinal chemistry (02.04.1993)
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2‘-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2‘-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Prakash, Thazha P, Manoharan, Muthiah, Kawasaki, Andrew M, Fraser, Allister S, Lesnik, Elena A, Sioufi, Namir, Leeds, Janet M, Teplova, Marianna, Egli, Martin
Published in Biochemistry (Easton) (01.10.2002)
Published in Biochemistry (Easton) (01.10.2002)
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Synthesis of 2′- O-[2-[( N, N-dialkylamino)oxy]ethyl]-modified oligonucleotides: hybridization affinity, resistance to nuclease, and protein binding characteristics
Prakash, Thazha P, Kawasaki, Andrew M, Lesnik, Elena A, Sioufi, Namir, Manoharan, Muthiah
Published in Tetrahedron (08.09.2003)
Published in Tetrahedron (08.09.2003)
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Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes
Lesnik, Elena A, Guinosso, Charles J, Kawasaki, Andrew M, Sasmor, Henri, Zounes, Maryann, Cummins, Lendell L, Ecker, David J, Cook, P. Dan, Freier, Susan M
Published in Biochemistry (Easton) (03.08.1993)
Published in Biochemistry (Easton) (03.08.1993)
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2‘-O-{2-[N,N-(Dialkyl)aminooxy]ethyl}- Modified Antisense Oligonucleotides
Prakash, Thazha P, Manoharan, Muthiah, Kawasaki, Andrew M, Lesnik, Elena A, Owens, Stephen R, Vasquez, Guillermo
Published in Organic letters (14.12.2000)
Published in Organic letters (14.12.2000)
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Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs
Kawasaki, Andrew M, Knapp, Richard J, Kramer, Thomas H, Walton, Amanda, Wire, William S, Hashimoto, Shinicki, Yamamura, Henry I, Porreca, Frank, Burks, Thomas F, Hruby, Victor J
Published in Journal of medicinal chemistry (19.03.1993)
Published in Journal of medicinal chemistry (19.03.1993)
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Design and synthesis of highly potent and selective cyclic dynorphin A analogs
Kawasaki, Andrew M, Knapp, Richard J, Kramer, Thomas H, Wire, William S, Vasquez, Olga S, Yamamura, Henry I, Burks, Thomas F, Hruby, Victor J
Published in Journal of medicinal chemistry (01.07.1990)
Published in Journal of medicinal chemistry (01.07.1990)
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Synthesis and cytotoxicity studies of 8-amino-6-methyl-2-.beta.-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene (7-Aza-TCN) and the corresponding 2'-deoxy- and arabinonucleoside analogues
Kawasaki, Andrew M, Wotring, Linda L, Townsend, Leroy B
Published in Journal of medicinal chemistry (01.12.1990)
Published in Journal of medicinal chemistry (01.12.1990)
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Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression
MONIA, B. P, LESNIK, E. A, GONZALEZ, C, LIMA, W. F, MCGEE, D, GUINOSSO, C. J, KAWASAKI, A. M, COOK, P. D, FREIER, S. M
Published in The Journal of biological chemistry (05.07.1993)
Published in The Journal of biological chemistry (05.07.1993)
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Zwitterionic oligonucleotides with 2′- O-[3-( N, N-dimethylamino)propyl]-RNA modification: synthesis and properties
Prakash, Thazha P., Manoharan, Muthiah, Fraser, Allister S., Kawasaki, Andrew M., Lesnik, Elena A., Owens, Stephen R.
Published in Tetrahedron letters (19.06.2000)
Published in Tetrahedron letters (19.06.2000)
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Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl ( 2′-O-AOE) modified oligonucleotides
Kawasaki, Andrew M., Casper, Martin D., Prakash, Thazha P., Manalili, Sheri, Sasmor, Henri, Manoharan, Muthiah, Cook, P.Dan
Published in Tetrahedron letters (22.01.1999)
Published in Tetrahedron letters (22.01.1999)
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