Discovery and Characterization of Allosteric WNK Kinase Inhibitors
Yamada, Ken, Zhang, Ji-Hu, Xie, Xiaoling, Reinhardt, Juergen, Xie, Amy Qiongshu, LaSala, Daniel, Kohls, Darcy, Yowe, David, Burdick, Debra, Yoshisue, Hajime, Wakai, Hiromichi, Schmidt, Isabel, Gunawan, Jason, Yasoshima, Kayo, Yue, Q. Kimberley, Kato, Mitsunori, Mogi, Muneto, Idamakanti, Neeraja, Kreder, Natasha, Drueckes, Peter, Pandey, Pramod, Kawanami, Toshio, Huang, Waanjeng, Yagi, Yukiko I, Deng, Zhan, Park, Hyi-Man
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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Synthesis and reactions of 5-tributylstannyl-4-fluoro-1H-pyrazole
Hanamoto, Takeshi, Suetake, Takao, Koga, Yukinori, Kawanami, Toshio, Furuno, Hiroshi, Inanaga, Junji
Published in Tetrahedron (04.06.2007)
Published in Tetrahedron (04.06.2007)
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Synthesis and crystal structure of 1,2,4-trifluoro-3,5,6-tris(triisopropylsilyl)benzene
Hanamoto, Takeshi, Koga, Yukinori, Kawanami, Toshio, Furuno, Hiroshi, Inanaga, Junji
Published in Tetrahedron letters (01.01.2006)
Published in Tetrahedron letters (01.01.2006)
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Remarkable effect of tris(4-fluorophenyl)phosphine oxide on the stabilization of chiral lanthanum complex catalysts. A new and practical protocol for the highly enantioselective epoxidation of conjugated enonesElectronic supplementary information (ESI) available: HPLC analysis of 2, 1H NMR data for 3 and 4, and crystal data for 5. See http://www.rsc.org/suppdata/ob/b4/b405882h
Kino, Rie, Daikai, Kazuhiro, Kawanami, Toshio, Furuno, Hiroshi, Inanaga, Junji
Published in Organic & biomolecular chemistry (2004)
Published in Organic & biomolecular chemistry (2004)
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Microstructure and Crystal Phase Development of Y2O3-Stabilized ZrO2 Polycrystal Fabricated by the Solid Phase Mixing and Sintering Method
OHNISHI, Hiroshi, FUKUHARA, Tetsurou, KAWANAMI, Toshio, SEKINO, Tohru, IKUHARA, Yuichi, NIIHARA, Koichi
Published in Journal of the Ceramic Society of Japan (01.01.2007)
Published in Journal of the Ceramic Society of Japan (01.01.2007)
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Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors
Argikar, Upendra, Blatter, Markus, Bednarczyk, Dallas, Chen, Zhuoliang, Cho, Young Shin, Doré, Michaël, Dumouchel, Jennifer L., Ho, Samuel, Hoegenauer, Klemens, Kawanami, Toshio, Mathieu, Simon, Meredith, Erik, Möbitz, Henrik, Murphy, Stephen K., Parthasarathy, Saravanan, Soldermann, Carole Pissot, Santos, Jobette, Silver, Serena, Skolnik, Suzanne, Stojanovic, Aleksandar
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers
Kawanami, Toshio, LaBonte, Laura R., Amin, Jakal, Thibodeaux, Stefan J., Lee, Cameron C., Argintaru, O. Andreea, Adams, Christopher M.
Published in International journal of pharmaceutics (30.07.2020)
Published in International journal of pharmaceutics (30.07.2020)
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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases
Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G., Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A., Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W., Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M., Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen, Eder, Joerg, Sedrani, Richard, Harrison, Richard A., Mogi, Muneto, Jaffee, Bruce D., Adams, Christopher M.
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Journal Article
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models
Yamada, Ken, Levell, Julian, Yoon, Taeyong, Kohls, Darcy, Yowe, David, Rigel, Dean F, Imase, Hidetomo, Yuan, Jun, Yasoshima, Kayo, DiPetrillo, Keith, Monovich, Lauren, Xu, Lingfei, Zhu, Meicheng, Kato, Mitsunori, Jain, Monish, Idamakanti, Neeraja, Taslimi, Paul, Kawanami, Toshio, Argikar, Upendra A, Kunjathoor, Vidya, Xie, Xiaoling, Yagi, Yukiko I, Iwaki, Yuki, Robinson, Zachary, Park, Hyi-Man
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma
Yamada, Ken, Brousseau, Margaret, Honma, Wataru, Iimura, Akiko, Imase, Hidetomo, Iwaki, Yuki, Kawanami, Toshio, LaSala, Daniel, Liang, Guiqing, Mitani, Hironobu, Nonomura, Kazuhiko, Ohmori, Osamu, Pan, Meihui, Rigel, Dean F, Umemura, Ichiro, Yasoshima, Kayo, Zhu, Guoming, Mogi, Muneto
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Journal Article
Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen
Palacios, Daniel S., Meredith, Erik, Kawanami, Toshio, Adams, Christopher, Chen, Xin, Darsigny, Veronique, Geno, Erin, Palermo, Mark, Baird, Daniel, Boynton, Geoffrey, Busby, Scott A., George, Elizabeth L., Guy, Chantale, Hewett, Jeffrey, Tierney, Laryssa, Thigale, Sachin, Weihofen, Wilhelm, Wang, Louis, White, Nicole, Yin, Ming, Argikar, Upendra A.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Journal Article
Scaffold Morphing Identifies 3‑Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)
Palacios, Daniel S, Meredith, Erik L, Kawanami, Toshio, Adams, Christopher M, Chen, Xin, Darsigny, Veronique, Palermo, Mark, Baird, Daniel, George, Elizabeth L, Guy, Chantale, Hewett, Jeffrey, Tierney, Laryssa, Thigale, Sachin, Wang, Louis, Weihofen, Wilhelm A
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Journal Article
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors
Kawanami, Toshio, Karki, Rajeshri G, Cody, Emma, Liu, Qian, Liang, Guiqing, Ksander, Gary M, Rigel, Dean F, Schiering, Nikolaus, Gong, Yongjin, Coppola, Gary M, Iwaki, Yuki, Sun, Robert, Neubert, Alan, Fan, Li, Ingles, Sara, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Jeng, Arco Y, Leung-Chu, Jennifer, Liu, Jing, Beil, Michael, Fu, Fumin, Chen, Wei, Cumin, Frederic, Wiesmann, Christian, Mogi, Muneto
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
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