Search Results - "KAWADA Hatsuo" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)

by Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry (01.02.2012)

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Journal Article

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

by Ohwada, Jun, Ebiike, Hirosato, Kawada, Hatsuo, Tsukazaki, Masao, Nakamura, Mitsuaki, Miyazaki, Takuya, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Kondoh, Osamu, Kuramoto, Shino, Ogawa, Kotaro, Aoki, Yuko, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry letters (15.03.2011)

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Journal Article

Synthetic Studies on the Taxane Skeleton: Construction of Eight-Membered Carbocyclic Rings by the Intramolecular B-Alkyl Suzuki−Miyaura Cross-Coupling Reaction

Synthetic Studies on the Taxane Skeleton: Construction of Eight-Membered Carbocyclic Rings by the Intramolecular B-Alkyl Suzuki−Miyaura Cross-Coupling Reaction

by Kawada, Hatsuo, Iwamoto, Mitsuhiro, Utsugi, Masayuki, Miyano, Masayuki, Nakada, Masahisa
Published in Organic letters (25.11.2004)

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Journal Article

Preparation of new chiral building blocks via asymmetric catalysis

Preparation of new chiral building blocks via asymmetric catalysis

by Iwamoto, Mitsuhiro, Kawada, Hatsuo, Tanaka, Tomoyuki, Nakada, Masahisa
Published in Tetrahedron letters (22.09.2003)

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Journal Article

Development of silicon-tethered anionic reaction and its application to the synthesis of chiral A-ring moieties of Taxol

Development of silicon-tethered anionic reaction and its application to the synthesis of chiral A-ring moieties of Taxol

by Iwamoto, Mitsuhiro, Miyano, Masayuki, Utsugi, Masayuki, Kawada, Hatsuo, Nakada, Masahisa
Published in Tetrahedron letters (15.11.2004)

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Journal Article

Synthetic studies on the seven- and eight-membered rings by the intramolecular Nozaki–Hiyama reaction of the allylic phosphates

Synthetic studies on the seven- and eight-membered rings by the intramolecular Nozaki–Hiyama reaction of the allylic phosphates

by Iwamoto, Mitsuhiro, Miyano, Masayuki, Utsugi, Masayuki, Kawada, Hatsuo, Nakada, Masahisa
Published in Tetrahedron letters (15.11.2004)

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Journal Article

CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS

CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS

by KOTAKE Tomoya, TAKANO Koji, KAGE Mirai, KAWADA Hatsuo
Year of Publication 16.05.2024

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Patent

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

by Ohta, Atsushi, Tanada, Mikimasa, Shinohara, Shojiro, Morita, Yuya, Nakano, Kazuhiko, Yamagishi, Yusuke, Takano, Ryusuke, Kariyuki, Shiori, Iida, Takeo, Matsuo, Atsushi, Ozeki, Kazuhisa, Emura, Takashi, Sakurai, Yuuji, Takano, Koji, Higashida, Atsuko, Kojima, Miki, Muraoka, Terushige, Takeyama, Ryuuichi, Kato, Tatsuya, Kimura, Kaori, Ogawa, Kotaro, Ohara, Kazuhiro, Tanaka, Shota, Kikuchi, Yasufumi, Hisada, Nozomi, Hayashi, Ryuji, Nishimura, Yoshikazu, Nomura, Kenichi, Tachibana, Tatsuhiko, Irie, Machiko, Kawada, Hatsuo, Torizawa, Takuya, Murao, Naoaki, Kotake, Tomoya, Tanaka, Masahiko, Ishikawa, Shiho, Miyake, Taiji, Tamiya, Minoru, Arai, Masako, Chiyoda, Aya, Akai, Sho, Sase, Hitoshi, Kuramoto, Shino, Ito, Toshiya, Shiraishi, Takuya, Kojima, Tetsuo, Iikura, Hitoshi
Published in Journal of the American Chemical Society (08.11.2023)

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Journal Article

Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display

Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display

by Kage, Mirai, Hayashi, Ryuji, Matsuo, Atsushi, Tamiya, Minoru, Kuramoto, Shino, Ohara, Kazuhiro, Irie, Machiko, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Kotake, Tomoya, Takeyama, Ryuuichi, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Hashimoto, Satoshi, Kawada, Hatsuo, Nishimura, Yoshikazu, Nii, Keiji, Sase, Hitoshi, Ohta, Atsushi, Kojima, Tetsuo, Iikura, Hitoshi, Tanada, Mikimasa, Shiraishi, Takuya
Published in Bioorganic & medicinal chemistry (01.08.2024)

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Journal Article

Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core

Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core

by Oki, Tomohiro, Tsukazaki, Masao, Shiina, Junichi, Fukuda, Hiroshi, Yamawaki, Minoru, Kito, Yasushi, Ishizawa, Takenori, Kinoshita, Kazutomo, Hara, Sosuke, Furuichi, Noriyuki, Kawada, Hatsuo, Ito, Toshiya, Tanaka, Kota, Maruyama, Noriaki, Tamaru, Daisuke, Ichige, Takahiro, Koizumi, Masatoshi, Hosoya, Yosuke, Kimura, Masahiro, Yamaguchi, Mami, Sato, Shigeki, Miyazaki, Yuta, Toya, Azusa, Iwamura, Hiroshi, Maeda, Kenji
Published in Organic process research & development (22.10.2024)

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Journal Article

HRAS NRAS KRAS PHARMACEUTICAL COMPOSITION COMPRISING CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

HRAS NRAS KRAS PHARMACEUTICAL COMPOSITION COMPRISING CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

by KAGE MIRAI, KOTAKE TOMOYA, HASHIMOTO SATOSHI, MORITA YUYA, WAKAMIYA YUMA, HAYASHI RYUJI, TAMIYA MINORU, KAWADA HATSUO, TAKANO KOJI
Year of Publication 10.06.2024

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Patent

PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS

PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS

by KAGE MIRAI, HASHIMOTO SATORU, KOTAKE TOMOYA, MORITA YUYA, WAKAMIYA YUMA, HAYASHI RYUJI, TAMIYA MINORU, KAWADA HATSUO, TAKANO KOJI
Year of Publication 21.05.2024

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Patent

PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS

PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS

by TAMIYA Minoru, MORITA Yuya, KOTAKE Tomoya, WAKAMIYA Yuma, TAKANO Koji, HASHIMOTO Satoshi, KAGE Mirai, KAWADA Hatsuo, HAYASHI Ryuji
Year of Publication 16.05.2024

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Patent

HRAS 및 NRAS에 대해서 선택적인 KRAS 저해 작용을 갖는 환상 화합물

HRAS 및 NRAS에 대해서 선택적인 KRAS 저해 작용을 갖는 환상 화합물

by KAGE MIRAI, KOTAKE TOMOYA, HASHIMOTO SATOSHI, MORITA YUYA, WAKAMIYA YUMA, HAYASHI RYUJI, TAMIYA MINORU, KAWADA HATSUO, TAKANO KOJI
Year of Publication 12.01.2024

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Patent

CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS

CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS

by TAMIYA Minoru, MORITA Yuya, KOTAKE Tomoya, WAKAMIYA Yuma, TAKANO Koji, HASHIMOTO Satoshi, KAGE Mirai, KAWADA Hatsuo, HAYASHI Ryuji
Year of Publication 09.11.2023

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Patent

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

by Tanada, Mikimasa, Tamiya, Minoru, Matsuo, Atsushi, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Irie, Machiko, Kotake, Tomoya, Takeyama, Ryuuichi, Kawada, Hatsuo, Hayashi, Ryuji, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Kage, Mirai, Hashimoto, Satoshi, Nii, Keiji, Sase, Hitoshi, Ohara, Kazuhiro, Ohta, Atsushi, Kuramoto, Shino, Nishimura, Yoshikazu, Iikura, Hitoshi, Shiraishi, Takuya
Published in Journal of the American Chemical Society (02.08.2023)

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Journal Article

9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors

9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors

by Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)

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Journal Article

Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability

Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability

by Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shinma, Nobuo, Tsukuda, Takuo, Ohwada, Jun
Published in Bioorganic & medicinal chemistry (15.12.2015)

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Journal Article

CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS

CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS

by WAKAMIYA, Yuma, HAYASHI, Ryuji, HASHIMOTO, Satoshi, TAMIYA, Minoru, KAWADA, Hatsuo, TAKANO, Koji, KAGE, Mirai, KOTAKE, Tomoya, MORITA, Yuya
Year of Publication 10.11.2022

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Patent

Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors

Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors

by Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry letters (15.06.2011)

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