Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results
Heuser, Michael, Palmisiano, Neil, Mantzaris, Ioannis, Mims, Alice, DiNardo, Courtney, Silverman, Lewis R, Wang, Eunice S, Fiedler, Walter, Baldus, Claudia, Schwind, Sebastian, Pardee, Timothy, Perl, Alexander E, Cai, Charles, Kaulfuss, Stefan, Lagkadinou, Eleni, Rentzsch, Christine, Wagner, Markus, Wilkinson, Gary, Wu, Bingyan, Jeffers, Michael, Genvresse, Isabelle, Krämer, Alwin
Published in Leukemia (01.11.2020)
Published in Leukemia (01.11.2020)
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Journal Article
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo
Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, von Deimling, Andreas
Published in Acta neuropathologica (01.04.2017)
Published in Acta neuropathologica (01.04.2017)
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Journal Article
Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia
Chaturvedi, Anuhar, Gupta, Charu, Gabdoulline, Razif, Borchert, Nora M, Goparaju, Ramya, Kaulfuss, Stefan, Görlich, Kerstin, Schottmann, Renate, Othman, Basem, Welzenbach, Julia, Panknin, Olaf, Wagner, Markus, Geffers, Robert, Ganser, Arnold, Thol, Felicitas, Jeffers, Michael, Haegebarth, Andrea, Heuser, Michael
Published in Haematologica (Roma) (01.02.2021)
Published in Haematologica (Roma) (01.02.2021)
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Journal Article
Characterization of Shiga Toxin-Producing Escherichia coli Strains Isolated from Human Patients in Germany over a 3-Year Period
BEUTIN, Lothar, KRAUSE, Gladys, ZIMMERMANN, Sonja, KAULFUSS, Stefan, GLEIER, Kerstin
Published in Journal of Clinical Microbiology (01.03.2004)
Published in Journal of Clinical Microbiology (01.03.2004)
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Journal Article
Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death
Klutzny, Saskia, Lesche, Ralf, Keck, Matthias, Kaulfuss, Stefan, Schlicker, Andreas, Christian, Sven, Sperl, Carolyn, Neuhaus, Roland, Mowat, Jeffrey, Steckel, Michael, Riefke, Björn, Prechtl, Stefan, Parczyk, Karsten, Steigemann, Patrick
Published in Cell death & disease (30.03.2017)
Published in Cell death & disease (30.03.2017)
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Journal Article
Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay
PAULY, Diana, KIRCHNER, Sebastian, STOERMANN, Britta, SCHREIBER, Tanja, KAULFUSS, Stefan, SCHADE, Rüdiger, ZBINDEN, Reto, AVONDET, Marc-André, DORNER, Martin B, DORNER, Brigitte G
Published in Analyst (London) (01.10.2009)
Published in Analyst (London) (01.10.2009)
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Journal Article
Non-Invasive Measurement of Drug and 2-HG Signals Using 19F and 1H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032
Wenger, Katharina J., Richter, Christian, Burger, Michael C., Urban, Hans, Kaulfuss, Stefan, Harter, Patrick N., Sreeramulu, Sridhar, Schwalbe, Harald, Steinbach, Joachim P., Hattingen, Elke, Bähr, Oliver, Pilatus, Ulrich
Published in Cancers (29.10.2020)
Published in Cancers (29.10.2020)
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Journal Article
Genetic Analysis of Enteropathogenic and Enterohemorrhagic Escherichia coli Serogroup O103 Strains by Molecular Typing of Virulence and Housekeeping Genes and Pulsed-Field Gel Electrophoresis
Beutin, Lothar, Kaulfuss, Stefan, Herold, Sylvia, Oswald, Eric, Schmidt, Herbert
Published in Journal of Clinical Microbiology (01.04.2005)
Published in Journal of Clinical Microbiology (01.04.2005)
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Journal Article
Genetical and functional investigation of fliC genes encoding flagellar serotype H4 in wildtype strains of Escherichia coli and in a laboratory E. coli K-12 strain expressing flagellar antigen type H48
Beutin, Lothar, Strauch, Eckhard, Zimmermann, Sonja, Kaulfuss, Stefan, Schaudinn, Christoph, Männel, Andrea, Gelderblom, Hans R
Published in BMC microbiology (24.01.2005)
Published in BMC microbiology (24.01.2005)
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Journal Article
Vibrio metschnikovii, a Rare Cause of Wound Infection
LINDE, Hans-Jörg, KOBUCH, Reinhard, JAYASINGHE, Salvia, REISCHL, Udo, LEHN, Norbert, KAULFUSS, Stefan, BEUTIN, Lothar
Published in Journal of Clinical Microbiology (01.10.2004)
Published in Journal of Clinical Microbiology (01.10.2004)
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Journal Article
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Bunse, Lukas, Pusch, Stefan, Bunse, Theresa, Sahm, Felix, Sanghvi, Khwab, Friedrich, Mirco, Alansary, Dalia, Sonner, Jana K, Green, Edward, Deumelandt, Katrin, Kilian, Michael, Neftel, Cyril, Uhlig, Stefanie, Kessler, Tobias, von Landenberg, Anna, Berghoff, Anna S, Marsh, Kelly, Steadman, Mya, Zhu, Dongwei, Nicolay, Brandon, Wiestler, Benedikt, Breckwoldt, Michael O, Al-Ali, Ruslan, Karcher-Bausch, Simone, Bozza, Matthias, Oezen, Iris, Kramer, Magdalena, Meyer, Jochen, Habel, Antje, Eisel, Jessica, Poschet, Gernot, Weller, Michael, Preusser, Matthias, Nadji-Ohl, Minou, Thon, Niklas, Burger, Michael C, Harter, Patrick N, Ratliff, Miriam, Harbottle, Richard, Benner, Axel, Schrimpf, Daniel, Okun, Jürgen, Herold-Mende, Christel, Turcan, Sevin, Kaulfuss, Stefan, Hess-Stumpp, Holger, Bieback, Karen, Cahill, Daniel P, Plate, Karl H, Hänggi, Daniel, Dorsch, Marion, Suvà, Mario L, Niemeyer, Barbara A, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Journal Article
BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe
Günther, Judith, Hillig, Roman C., Zimmermann, Katja, Kaulfuss, Stefan, Lemos, Clara, Nguyen, Duy, Rehwinkel, Hartmut, Habgood, Matthew, Lechner, Christian, Neuhaus, Roland, Ganzer, Ursula, Drewes, Mark, Chai, Jijie, Bouché, Léa
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors
Wick, Antje, Bähr, Oliver, Schuler, Martin, Rohrberg, Kristoffer, Chawla, Sant P, Janku, Filip, Schiff, David, Heinemann, Volker, Narita, Yoshitaka, Lenz, Heinz-Josef, Ikeda, Masafumi, Ando, Yuichi, Wick, Wolfgang, Steinbach, Joachim P, Burger, Michael C, Wenger, Katharina, Lassen, Ulrik, Sankhala, Kamalesh K, Roggia, Cristiana, Genvresse, Isabelle, Munhoz, Catya, Rentzsch, Christine, Reschke, Susanne, Langer, Simon, Wagner, Markus, Kaulfuss, Stefan, Cai, Charles, Lagkadinou, Eleni, Jeffers, Michael, Peña, Carol, Tabatabai, Ghazaleh
Published in Clinical cancer research (15.05.2021)
Published in Clinical cancer research (15.05.2021)
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Journal Article
Abstract 2077: Activity of DHODH inhibitor BAY2402234 in subcutaneous and intracranial models of SCLC
Kaulfuss, Stefan, Janzer, Andreas, Siemeister, Gerhard, Borowicz, Renan, Jaensch, Katrin, Gutberlet, Katrin, Schlenz, Ricarda, Triller, Andrea, Eheim, Ashley, Jeffers, Michael, Christian, Sven
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract C079: Comprehensive immunophenotypic profiling sheds light on the dynamic interplay between immune cells in the 4T1 breast cancer model upon anti-PD1 and anti-CTLA4 immunotherapy
Nikolaou, Christos, Heller, Simon, Kaulfuss, Stefan, Stresemann, Carlo, Eichten, Alexandra, von Ahsen, Oliver, Lange, Martin
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Efficacy of Chemotherapy, Phd-Inhibitor Molidustat or BRD4 Inhibitor JQ1 in Combination with Targeted Inhibition of Mutated IDH1 in Human AML In Vivo
Chaturvedi, Anuhar, Gupta, Charu, Kaulfuss, Stefan, Othman, Basem, Görlich, Kerstin, Schottmann, Renate, Panknin, Olaf, Wagner, Markus, Ganser, Arnold, Jeffers, Michael, Haegebarth, Andrea, Heuser, Michael
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12
Lewis, Timothy A., Ellermann, Manuel, Kopitz, Charlotte, Lange, Martin, de Waal, Luc, Wu, Xiaoyun, Tersteegen, Adrian, Denner, Karsten, Lienau, Philip, Kaulfuss, Stefan, Goldoni, Silvia, Meyerson, Matthew, Greulich, Heidi, Gradl, Stefan N.
Published in ACS medicinal chemistry letters (10.09.2024)
Published in ACS medicinal chemistry letters (10.09.2024)
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Journal Article
Abstract 2182: Preclincial in vitro and in vivo combination therapies for mutant IDH1R132 tumors with BAY 1436032
Kaulfuss, Stefan, Zaman, Julia, Chaturvedi, Anuhar, Hess-Stumpp, Holger, Höde, Jennifer, Biber, Ricarda, Borowicz, Renan, Heuser, Michael, Deimling, Andreas von, Pusch, Stefan
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 1049: Pharmacological characterization of a novel potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with robust in vivo efficacy and increased therapeutic index with niacin supplementation
Quanz, Maria, Merz, Claudia, Bernthaler, Andreas, Kaulfuss, Stefan, Richter, Anja, Bauser, Marcus, Haegebarth, Andrea
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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