Poly (ADP-ribose) polymerase inhibitors: recent advances and future development
Scott, Clare L, Swisher, Elizabeth M, Kaufmann, Scott H
Published in Journal of clinical oncology (20.04.2015)
Published in Journal of clinical oncology (20.04.2015)
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Journal Article
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
Patel, Anand G., Sarkaria, Jann N., Kaufmann, Scott H., Hanawalt, Philip C.
Published in Proceedings of the National Academy of Sciences - PNAS (22.02.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (22.02.2011)
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Journal Article
PARP inhibition: PARP1 and beyond
Patel, Anand, Hendzel, Michael J, Kaufmann, Scott H, Rouleau, Michèle, Poirier, Guy G
Published in Nature reviews. Cancer (01.04.2010)
Published in Nature reviews. Cancer (01.04.2010)
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BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Lin, Kevin K, Harrell, Maria I, Oza, Amit M, Oaknin, Ana, Ray-Coquard, Isabelle, Tinker, Anna V, Helman, Elena, Radke, Marc R, Say, Carmen, Vo, Lan-Thanh, Mann, Elaina, Isaacson, Jeffrey D, Maloney, Lara, O'Malley, David M, Chambers, Setsuko K, Kaufmann, Scott H, Scott, Clare L, Konecny, Gottfried E, Coleman, Robert L, Sun, James X, Giordano, Heidi, Brenton, James D, Harding, Thomas C, McNeish, Iain A, Swisher, Elizabeth M
Published in Cancer discovery (01.02.2019)
Published in Cancer discovery (01.02.2019)
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Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2
French, Andrea J, Natesampillai, Sekar, Krogman, Ashton, Correia, Cristina, Peterson, Kevin L, Alto, Alecia, Chandrasekar, Aswath P, Misra, Anisha, Li, Ying, Kaufmann, Scott H, Badley, Andrew D, Cummins, Nathan W
Published in PLoS pathogens (19.10.2020)
Published in PLoS pathogens (19.10.2020)
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Apoptotic stress causes mtDNA release during senescence and drives the SASP
Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.
Published in Nature (London) (19.10.2023)
Published in Nature (London) (19.10.2023)
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Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial
Swisher, Elizabeth M, Dr Prof, Lin, Kevin K, PhD, Oza, Amit M, Prof, Scott, Clare L, PhD, Giordano, Heidi, MA, Sun, James, PhD, Konecny, Gottfried E, MD, Coleman, Robert L, Prof, Tinker, Anna V, MD, O'Malley, David M, MD, Kristeleit, Rebecca S, MD, Ma, Ling, MD, Bell-McGuinn, Katherine M, MD, Brenton, James D, Prof, Cragun, Janiel M, MD, Oaknin, Ana, MD, Ray-Coquard, Isabelle, Prof, Harrell, Maria I, PhD, Mann, Elaina, MS, Kaufmann, Scott H, Prof, Floquet, Anne, MD, Leary, Alexandra, MD, Harding, Thomas C, PhD, Goble, Sandra, MS, Maloney, Lara, BA, Isaacson, Jeff, PhD, Allen, Andrew R, MD, Rolfe, Lindsey, MBChB, Yelensky, Roman, PhD, Raponi, Mitch, PhD, McNeish, Iain A, Prof
Published in The lancet oncology (2017)
Published in The lancet oncology (2017)
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Journal Article
Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro
PATEL, Anand G, DE LORENZO, Silvana B, FLATTEN, Karen S, POIRIER, Guy G, KAUFMANN, Scott H
Published in Clinical cancer research (15.03.2012)
Published in Clinical cancer research (15.03.2012)
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Characterization of an alternative BAK-binding site for BH3 peptides
Ye, Kaiqin, Meng, Wei X., Sun, Hongbin, Wu, Bo, Chen, Meng, Pang, Yuan-Ping, Gao, Jia, Wang, Hongzhi, Wang, Junfeng, Kaufmann, Scott H., Dai, Haiming
Published in Nature communications (03.07.2020)
Published in Nature communications (03.07.2020)
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Journal Article
Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial
Konstantinopoulos, Panagiotis A, Barry, William T, Birrer, Michael, Westin, Shannon N, Cadoo, Karen A, Shapiro, Geoffrey I, Mayer, Erica L, O'Cearbhaill, Roisin E, Coleman, Robert L, Kochupurakkal, Bose, Whalen, Christin, Curtis, Jennifer, Farooq, Sarah, Luo, Weixiu, Eismann, Julia, Buss, Mary K, Aghajanian, Carol, Mills, Gordon B, Palakurthi, Sangeetha, Kirschmeier, Paul, Liu, Joyce, Cantley, Lewis C, Kaufmann, Scott H, Swisher, Elizabeth M, D'Andrea, Alan D, Winer, Eric, Wulf, Gerburg M, Matulonis, Ursula A
Published in The lancet oncology (01.04.2019)
Published in The lancet oncology (01.04.2019)
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Journal Article
ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
HUNTOON, Catherine J, FLATTEN, Karen S, WAHNER HENDRICKSON, Andrea E, HUEHLS, Amelia M, SUTOR, Shari L, KAUFMANN, Scott H, KARNITZ, Larry M
Published in Cancer research (Chicago, Ill.) (15.06.2013)
Published in Cancer research (Chicago, Ill.) (15.06.2013)
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Journal Article
Evaluation of the BH3-only Protein Puma as a Direct Bak Activator
Dai, Haiming, Pang, Yuan-Ping, Ramirez-Alvarado, Marina, Kaufmann, Scott H.
Published in The Journal of biological chemistry (03.01.2014)
Published in The Journal of biological chemistry (03.01.2014)
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Journal Article
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
Carr, Ryan M., Vorobyev, Denis, Lasho, Terra, Marks, David L., Tolosa, Ezequiel J., Vedder, Alexis, Almada, Luciana L., Yurcheko, Andrey, Padioleau, Ismael, Alver, Bonnie, Coltro, Giacomo, Binder, Moritz, Safgren, Stephanie L., Horn, Isaac, You, Xiaona, Solary, Eric, Balasis, Maria E., Berger, Kurt, Hiebert, James, Witzig, Thomas, Buradkar, Ajinkya, Graf, Temeida, Valent, Peter, Mangaonkar, Abhishek A., Robertson, Keith D., Howard, Matthew T., Kaufmann, Scott H., Pin, Christopher, Fernandez-Zapico, Martin E., Geissler, Klaus, Droin, Nathalie, Padron, Eric, Zhang, Jing, Nikolaev, Sergey, Patnaik, Mrinal M.
Published in Nature communications (18.05.2021)
Published in Nature communications (18.05.2021)
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COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
Phillips-Krawczak, Christine A, Singla, Amika, Starokadomskyy, Petro, Deng, Zhihui, Osborne, Douglas G, Li, Haiying, Dick, Christopher J, Gomez, Timothy S, Koenecke, Megan, Zhang, Jin-San, Dai, Haiming, Sifuentes-Dominguez, Luis F, Geng, Linda N, Kaufmann, Scott H, Hein, Marco Y, Wallis, Mathew, McGaughran, Julie, Gecz, Jozef, Sluis, Bart van de, Billadeau, Daniel D, Burstein, Ezra
Published in Molecular biology of the cell (01.01.2015)
Published in Molecular biology of the cell (01.01.2015)
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A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice
Zhang, Haoxing, Liu, Hailong, Chen, Yali, Yang, Xu, Wang, Panfei, Liu, Tongzheng, Deng, Min, Qin, Bo, Correia, Cristina, Lee, Seungbaek, Kim, Jungjin, Sparks, Melanie, Nair, Asha A., Evans, Debra L., Kalari, Krishna R., Zhang, Pumin, Wang, Liewei, You, Zhongsheng, Kaufmann, Scott H., Lou, Zhenkun, Pei, Huadong
Published in Nature communications (05.01.2016)
Published in Nature communications (05.01.2016)
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Journal Article
Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants
Prakash, Rohit, Rawal, Yashpal, Sullivan, Meghan R, Grundy, McKenzie K, Bret, Hélène, Mihalevic, Michael J, Rein, Hayley L, Baird, Jared M, Darrah, Kristie, Zhang, Fang, Wang, Raymond, Traina, Tiffany A, Radke, Marc R, Kaufmann, Scott H, Swisher, Elizabeth M, Guérois, Raphaël, Modesti, Mauro, Sung, Patrick, Jasin, Maria, Bernstein, Kara A
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2022)
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Journal Article
Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Kondrashova, Olga, Nguyen, Minh, Shield-Artin, Kristy, Tinker, Anna V, Teng, Nelson N H, Harrell, Maria I, Kuiper, Michael J, Ho, Gwo-Yaw, Barker, Holly, Jasin, Maria, Prakash, Rohit, Kass, Elizabeth M, Sullivan, Meghan R, Brunette, Gregory J, Bernstein, Kara A, Coleman, Robert L, Floquet, Anne, Friedlander, Michael, Kichenadasse, Ganessan, O'Malley, David M, Oza, Amit, Sun, James, Robillard, Liliane, Maloney, Lara, Bowtell, David, Giordano, Heidi, Wakefield, Matthew J, Kaufmann, Scott H, Simmons, Andrew D, Harding, Thomas C, Raponi, Mitch, McNeish, Iain A, Swisher, Elizabeth M, Lin, Kevin K, Scott, Clare L
Published in Cancer discovery (01.09.2017)
Published in Cancer discovery (01.09.2017)
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