Search Results - "KAUFFMAN, Jack A" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308

Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308

by Hoekstra, William J, Maryanoff, Bruce E, Damiano, Bruce P, Andrade-Gordon, Patricia, Cohen, Judith H, Costanzo, Michael J, Haertlein, Barbara J, Hecker, Leonard R, Hulshizer, Becky L, Kauffman, Jack A, Keane, Patricia, McComsey, David F, Mitchell, John A, Scott, Lorraine, Shah, Rekha D, Yabut, Stephen C
Published in Journal of medicinal chemistry (16.12.1999)

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Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions

Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions

by Maryanoff, Bruce E, Greco, Michael N, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A, Nicolaou, K. C, Liu, Aijun, Brungs, Peter H
Published in Journal of the American Chemical Society (01.02.1995)

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A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo

A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo

by de Garavilla, Lawrence, Greco, Michael N, Sukumar, Narayanasami, Chen, Zhi-Wei, Pineda, Agustin O, Mathews, F Scott, Di Cera, Enrico, Giardino, Edward C, Wells, Grace I, Haertlein, Barbara J, Kauffman, Jack A, Corcoran, Thomas W, Derian, Claudia K, Eckardt, Annette J, Damiano, Bruce P, Andrade-Gordon, Patricia, Maryanoff, Bruce E
Published in The Journal of biological chemistry (06.05.2005)

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In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design

by Costanzo, Michael J, Almond, Harold R, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W, Giardino, Edward C, Kauffman, Jack A, Lewis, Joan M, de Garavilla, Lawrence, Haertlein, Barbara J, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (24.03.2005)

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Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone

Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone

by Costanzo, Michael J, Yabut, Stephen C, Almond, Harold R, Andrade-Gordon, Patricia, Corcoran, Thomas W, de Garavilla, Lawrence, Kauffman, Jack A, Abraham, William M, Recacha, Rosario, Chattopadhyay, Debashish, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (28.08.2003)

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Nonpeptide Inhibitors of Cathepsin G: Optimization of a Novel β-Ketophosphonic Acid Lead by Structure-Based Drug Design

Nonpeptide Inhibitors of Cathepsin G: Optimization of a Novel β-Ketophosphonic Acid Lead by Structure-Based Drug Design

by Greco, Michael N, Hawkins, Michael J, Powell, Eugene T, Almond, Harold R, Corcoran, Thomas W, de Garavilla, Lawrence, Kauffman, Jack A, Recacha, Rosario, Chattopadhyay, Debashish, Andrade-Gordon, Patricia, Maryanoff, Bruce E
Published in Journal of the American Chemical Society (17.04.2002)

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In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design

by Costanzo, Michael J, Almond, Harold R, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W, Giardino, Edward C, Kauffman, Jack A, Lewis, Joan M, de Garavilla, Lawrence, Haertlein, Barbara J, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (15.11.2007)

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1,2,4-Triazolo[3,4- a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists

1,2,4-Triazolo[3,4- a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists

by Lawson, Edward C, Hoekstra, William J, Addo, Michael F, Andrade-Gordon, Patricia, Damiano, Bruce P, Kauffman, Jack A, Mitchell, John A, Maryanoff, Bruce E
Published in Bioorganic & medicinal chemistry letters (08.10.2001)

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A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase

A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase

by de Garavilla, Lawrence, Greco, Michael N., Sukumar, Narayanasami, Chen, Zhi-Wei, Pineda, Agustin O., Mathews, F. Scott, Di Cera, Enrico, Giardino, Edward C., Wells, Grace I., Haertlein, Barbara J., Kauffman, Jack A., Corcoran, Thomas W., Derian, Claudia K., Eckardt, Annette J., Damiano, Bruce P., Andrade-Gordon, Patricia, Maryanoff, Bruce E.
Published in The Journal of biological chemistry (06.05.2005)

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Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist

Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist

by Damiano, Bruce P, Mitchell, John A, Giardino, Edward, Corcoran, Thomas, Haertlein, Barbara J, de Garavilla, Lawrence, Kauffman, Jack A, Hoekstra, William J, Maryanoff, Bruce E, Andrade-Gordon, Patricia
Published in Thrombosis research (15.10.2001)

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Potent Thrombin Inhibitors That Probe the S1‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group

Potent Thrombin Inhibitors That Probe the S1‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group

by Costanzo, Michael J, Maryanoff, Bruce E, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A, Lewis, Joan M, Krishnan, Raman, Tulinsky, Alexander
Published in Journal of medicinal chemistry (02.08.1996)

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Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issues

Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issues

by Maryanoff, Bruce E, Zhang, Han-Cheng, Greco, Michael N, Glover, Karen A, Kauffman, Jack A, Andrade-Gordon, Patricia
Published in Bioorganic & medicinal chemistry (01.08.1995)

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Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions. [Erratum to document cited in CA122:161323]

Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions. [Erratum to document cited in CA122:161323]

by Maryanoff, Bruce E, Greco, Michael N, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A, Nicolaou, K. C, Liu, Aijun, Brungs, Peter H
Published in Journal of the American Chemical Society (01.05.1995)

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Synthesis and structure-activity relationship of 6-substituted purine derivatives as novel selective positive inotropes

Synthesis and structure-activity relationship of 6-substituted purine derivatives as novel selective positive inotropes

by Press, Jeffery B, Falotico, Robert, Hajos, Zoltan G, Sawyers, Rebecca Anne, Kanojia, Ramesh M, Williams, Louella, Haertlein, Barbara, Kauffman, Jack A, Lakas-Weiss, Constance, Salata, Joseph J
Published in Journal of medicinal chemistry (01.11.1992)

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In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S-1 ' subsite and its implications to structure-based drug design

In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S-1 ' subsite and its implications to structure-based drug design

by Costanzo, MJ, Almond, HR, Hecker, LR, Schott, MR, Yabut, SC, Zhang, HC, Andrade-Gordon, P, Corcoran, TW, Giardino, EC, Kauffman, JA, Lewis, JM, de Garavilla, L, Haertlein, BJ, Maryanoff, BE
Published in Journal of medicinal chemistry (24.03.2005)

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Journal Article

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design

by Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A., Lewis, Joan M., de Garavilla, Lawrence, Haertlein, Barbara J., Maryanoff, Bruce E.
Published in Journal of medicinal chemistry (15.11.2007)

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Journal Article

In-depth study of tripeptide-based α-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug designs

In-depth study of tripeptide-based α-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug designs

by COSTANZO, Michael J, ALMOND, Harold R, LEWIS, Joan M, DE GARAVILLA, Lawrence, HAERTLEIN, Barbara J, MARYANOFF, Bruce E, HECKER, Leonard R, SCHOTT, Mary R, YABUT, Stephen C, ZHANG, Han-Cheng, ANDRADE-GORDON, Patricia, CORCORAN, Thomas W, GIARDINO, Edward C, KAUFFMAN, Jack A
Published in Journal of medicinal chemistry (2005)

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Potent thrombin inhibitors that probe the S-1' subsite: Tripeptide transition state analogues based on a heterocycle-activated carbonyl group

Potent thrombin inhibitors that probe the S-1' subsite: Tripeptide transition state analogues based on a heterocycle-activated carbonyl group

by Costanzo, MJ, Maryanoff, BE, Hecker, LR, Schott, MR, Yabut, SC, Zhang, HC, AndradeGordon, P, Kauffman, JA, Lewis, JM, Krishnan, R, Tulinsky, A
Published in Journal of medicinal chemistry (02.08.1996)

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Molecular Basis for the Inhibition of Human α-Thrombin by the Macrocyclic Peptide Cyclotheonamide A

Molecular Basis for the Inhibition of Human α-Thrombin by the Macrocyclic Peptide Cyclotheonamide A

by Maryanoff, Bruce E., Qiu, Xiayang, Padmanabhan, K. P., Tulinsky, Alexander, Almond, Harold R., Andrade-Gordon, Patricia, Greco, Michael N., Kauffman, Jack A., Nicolaou, K. C., Liu, Aijn, Brungs, Peter H., Fusetani, Nobuhiro
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1993)

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Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

by Hoekstra, William J., Hulshizer, Becky L., McComsey, David F., Andrade-Gordon, Patricia, Kauffman, Jack A., Addo, Michael F., Oksenberg, Donna, Scarborough, Robert M., Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry letters (07.07.1998)

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