The cGAS-STING pathway as a therapeutic target in inflammatory diseases
Decout, Alexiane, Katz, Jason D, Venkatraman, Shankar, Ablasser, Andrea
Published in Nature reviews. Immunology (01.09.2021)
Published in Nature reviews. Immunology (01.09.2021)
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Journal Article
Divergent and Regioselective Synthesis of Pyrazolo[1,5‑a]pyridines and Imidazo[1,5‑a]pyridines
Mennie, Katrina M, Reutershan, Michael H, White, Catherine, Adams, Bruce, Becker, Bridget, Deng, James, Katz, Jason D, LaBlue, Elisabeth, Margrey, Kaila, Saurí, Josep
Published in Organic letters (18.06.2021)
Published in Organic letters (18.06.2021)
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Journal Article
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Journal Article
Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors
Zhou, Hua, McGowan, Meredeth A., Lipford, Kathryn, Christopher, Matthew, Fradera, Xavier, Witter, David, Lesburg, Charles A., Li, Chaomin, Methot, Joey L., Lampe, John, Achab, Abdelghani, Shaffer, Lynsey, Goldenblatt, Peter, Shah, Sanjiv, Bass, Alan, Schroeder, Gottfried, Chen, Dapeng, Zeng, Haoyu, Augustin, Martin A., Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (01.01.2020)
Published in Bioorganic & medicinal chemistry letters (01.01.2020)
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Journal Article
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening
Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Journal Article
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability
Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580]
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Journal Article
Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors
Simov, Vladimir, Deshmukh, Sujal V., Dinsmore, Christopher J., Elwood, Fiona, Fernandez, Rafael B., Garcia, Yudith, Gibeau, Craig, Gunaydin, Hakan, Jung, Joon, Katz, Jason D., Kraybill, Brian, Lapointe, Blair, Patel, Sangita B., Siu, Tony, Su, Hua, Young, Jonathan R.
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
Published in Bioorganic & medicinal chemistry letters (01.04.2016)
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Journal Article
An Aldol Approach to the Synthesis of the EF Fragment of Spongistatin 1
Crimmins, Michael T, Katz, Jason D, McAtee, Laura C, Tabet, Elie A, Kirincich, Steven J
Published in Organic letters (22.03.2001)
Published in Organic letters (22.03.2001)
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Journal Article
Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors
Katz, Jason D., Haidle, Andrew, Childers, Kaleen K., Zabierek, Anna A., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Su, Hua-Poo, Munshi, Sanjeev, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
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Journal Article
MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
PAN, Bo-Sheng, CHAN, Grace K. Y, JEWELL, James P, KARIV, Ilona, KATZ, Jason D, KUNII, Kaiko, WEI LU, LUTTERBACH, Bart A, PAWELETZ, Cloud P, XIANLU QU, REILLY, John F, SZEWCZAK, Alexander A, CHENARD, Melissa, QINWEN ZENG, KOHL, Nancy E, DINSMORE, Christopher J, CHI, An, DAVIS, Lenora J, DESHMUKH, Sujal V, GIBBS, Jackson B, GIL, Susana, GAOZHEN HANG, HATCH, Harold
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Journal Article
Discovery of a 5H-Benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer
Katz, Jason D, Jewell, James P, Guerin, David J, Lim, Jongwon, Dinsmore, Christopher J, Deshmukh, Sujal V, Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D, Dahlberg, William K, Davis, Lenora, Falcone, Danielle, Gabarda, Ana E, Hang, Gaozhen, Hatch, Harold, Holmes, Rachael, Kunii, Kaiko, Lumb, Kevin J, Lutterbach, Bart, Mathvink, Robert, Nazef, Naim, Patel, Sangita B, Qu, Xianlu, Reilly, John F, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Spencer, Kerrie B, Szewczak, Alexander A, Walker, Deborah, Wang, Wenxian, Young, Jonathan, Zeng, Qinwen
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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Journal Article
MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation
Haidle, Andrew M., Childers, Kaleen K., Zabierek, Anna A., Katz, Jason D., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
Published in Bioorganic & medicinal chemistry letters (01.01.2017)
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Journal Article
Preparation of a Stable Trifluoroborate Salt for the Synthesis of 1-Aryl-2,2-difluoro-enolethers and/or 2,2-Difluoro-1-aryl-ketones via Palladium-Mediated Cross-Coupling
Katz, Jason D, Lapointe, Blair T, Dinsmore, Christopher J
Published in Journal of organic chemistry (20.11.2009)
Published in Journal of organic chemistry (20.11.2009)
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Journal Article
Asymmetric Total Synthesis of Spongistatins 1 and 2
Crimmins, Michael T, Katz, Jason D, Washburn, David G, Allwein, Shawn P, McAtee, Laura F
Published in Journal of the American Chemical Society (22.05.2002)
Published in Journal of the American Chemical Society (22.05.2002)
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Journal Article
Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor
Stewart, Gavin W, Brands, Karel M. J, Brewer, Sarah E, Cowden, Cameron J, Davies, Antony J, Edwards, John S, Gibson, Andrew W, Hamilton, Simon E, Katz, Jason D, Keen, Stephen P, Mullens, Peter R, Scott, Jeremy P, Wallace, Debra J, Wise, Christopher S
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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