Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists
Smith, Brian J, Huang, Kun, Kong, Geoffrey, Chan, Shu Jin, Nakagawa, Satoe, Menting, John G, Hu, Shi-Quan, Whittaker, Jonathan, Steiner, Donald F, Katsoyannis, Panayotis G, Ward, Colin W, Weiss, Michael A, Lawrence, Michael C
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2010)
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Diabetes-Associated Mutations in Insulin Identify Invariant Receptor Contacts
Xu, Bin, Hu, Shi-Quan, Chu, Ying-Chi, Wang, Shuhua, Wang, Run-Ying, Nakagawa, Satoe H, Katsoyannis, Panayotis G, Weiss, Michael A
Published in Diabetes (New York, N.Y.) (01.06.2004)
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Achilles' Heel in an Amyloidogenic Protein and Its Repair: INSULIN FIBRILLATION AND THERAPEUTIC DESIGN
Yang, Yanwu, Petkova, Aneta, Huang, Kun, Xu, Bin, Hua, Qing-xin, Ye, I. Ju, Chu, Ying-Chi, Hu, Shi-Quan, Phillips, Nelson B, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Mackin, Robert B, Katsoyannis, Panayotis G, Tycko, Robert, Weiss, Michael A
Published in The Journal of biological chemistry (02.04.2010)
Published in The Journal of biological chemistry (02.04.2010)
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Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning: INSULIN INSERTS A DETACHABLE ARM BETWEEN RECEPTOR DOMAINS
Xu, Bin, Huang, Kun, Chu, Ying-Chi, Hu, Shi-Quan, Nakagawa, Satoe, Wang, Shuhua, Wang, Run-Ying, Whittaker, Jonathan, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (22.05.2009)
Published in The Journal of biological chemistry (22.05.2009)
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Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS
Hua, Qing-xin, Xu, Bin, Huang, Kun, Hu, Shi-Quan, Nakagawa, Satoe, Jia, Wenhua, Wang, Shuhua, Whittaker, Jonathan, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (22.05.2009)
Published in The Journal of biological chemistry (22.05.2009)
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Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity
Liu, Ming, Wan, Zhu-Li, Chu, Ying-Chi, Aladdin, Hassan, Klaproth, Birgit, Choquette, Meredith, Hua, Qing-Xin, Mackin, Robert B, Rao, J Sunil, De Meyts, Pierre, Katsoyannis, Panayotis G, Arvan, Peter, Weiss, Michael A
Published in The Journal of biological chemistry (11.12.2009)
Published in The Journal of biological chemistry (11.12.2009)
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A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE
Huang, Kun, Chan, Shu Jin, Hua, Qing-xin, Chu, Ying-Chi, Wang, Run-ying, Klaproth, Birgit, Jia, Wenhua, Whittaker, Jonathan, De Meyts, Pierre, Nakagawa, Satoe H, Steiner, Donald F, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (30.11.2007)
Published in The Journal of biological chemistry (30.11.2007)
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Chiral Mutagenesis of Insulin: CONTRIBUTION OF THE B20-B23 β-TURN TO ACTIVITY AND STABILITY
Nakagawa, Satoe H, Hua, Qing-xin, Hu, Shi-Quan, Jia, Wenhua, Wang, Shuhua, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (04.08.2006)
Published in The Journal of biological chemistry (04.08.2006)
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Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
Zhao, Ming, Wan, Zhu-li, Whittaker, Linda, Xu, Bin, Phillips, Nelson B, Katsoyannis, Panayotis G, Ismail-Beigi, Faramarz, Whittaker, Jonathan, Weiss, Michael A
Published in The Journal of biological chemistry (13.11.2009)
Published in The Journal of biological chemistry (13.11.2009)
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How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor
Huang, Kun, Xu, Bin, Hu, Shi-Quan, Chu, Ying-Chi, Hua, Qing-Xin, Qu, Yan, Li, Biaoru, Wang, Shuhua, Wang, Run-Ying, Nakagawa, Satoe H, Theede, Anne Mette, Whittaker, Jonathan, De Meyts, Pierre, Katsoyannis, Panayotis G, Weiss, Michael A
Published in Journal of molecular biology (06.08.2004)
Published in Journal of molecular biology (06.08.2004)
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Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama
Wan, Zhu-li, Huang, Kun, Xu, Bin, Hu, Shi-Quan, Wang, Shuhua, Chu, Ying-Chi, Katsoyannis, Panayotis G, Weiss, Michael A
Published in Biochemistry (Easton) (05.04.2005)
Published in Biochemistry (Easton) (05.04.2005)
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Diabetes-Associated Mutations in Insulin: Consecutive Residues in the B Chain Contact Distinct Domains of the Insulin Receptor
Xu, Bin, Hu, Shi-Quan, Chu, Ying-Chi, Huang, Kun, Nakagawa, Satoe H, Whittaker, Jonathan, Katsoyannis, Panayotis G, Weiss, Michael A
Published in Biochemistry (Easton) (06.07.2004)
Published in Biochemistry (Easton) (06.07.2004)
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Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
Hua, Qing-Xin, Chu, Ying-Chi, Jia, Wenhua, Phillips, Nelson F B, Wang, Run-Ying, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (08.11.2002)
Published in The Journal of biological chemistry (08.11.2002)
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Enhancing the Activity of Insulin at the Receptor Interface: Crystal Structure and Photo-Cross-Linking of A8 Analogues
Wan, Zhuli, Xu, Bin, Huang, Kun, Chu, Ying-Chi, Li, Biaoru, Nakagawa, Satoe H, Qu, Yan, Hu, Shi-Quan, Katsoyannis, Panayotis G, Weiss, Michael A
Published in Biochemistry (Easton) (28.12.2004)
Published in Biochemistry (Easton) (28.12.2004)
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Crystal Structure of a “Nonfoldable” Insulin
Liu, Ming, Wan, Zhu-li, Chu, Ying-Chi, Aladdin, Hassan, Klaproth, Birgit, Choquette, Meredith, Hua, Qing-xin, Mackin, Robert B., Rao, J.Sunil, De Meyts, Pierre, Katsoyannis, Panayotis G., Arvan, Peter, Weiss, Michael A.
Published in The Journal of biological chemistry (01.12.2009)
Published in The Journal of biological chemistry (01.12.2009)
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Journal Article
Design of an Insulin Analog with Enhanced Receptor Binding Selectivity
Zhao, Ming, Wan, Zhu-li, Whittaker, Linda, Xu, Bin, Phillips, Nelson B., Katsoyannis, Panayotis G., Ismail-Beigi, Faramarz, Whittaker, Jonathan, Weiss, Michael A.
Published in The Journal of biological chemistry (13.11.2009)
Published in The Journal of biological chemistry (13.11.2009)
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Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning
Xu, Bin, Huang, Kun, Chu, Ying-Chi, Hu, Shi-Quan, Nakagawa, Satoe, Wang, Shuhua, Wang, Run-Ying, Whittaker, Jonathan, Katsoyannis, Panayotis G., Weiss, Michael A.
Published in The Journal of biological chemistry (22.05.2009)
Published in The Journal of biological chemistry (22.05.2009)
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Journal Article
Enhancing the Activity of a Protein by Stereospecific Unfolding
Hua, Qing-xin, Xu, Bin, Huang, Kun, Hu, Shi-Quan, Nakagawa, Satoe, Jia, Wenhua, Wang, Shuhua, Whittaker, Jonathan, Katsoyannis, Panayotis G., Weiss, Michael A.
Published in The Journal of biological chemistry (22.05.2009)
Published in The Journal of biological chemistry (22.05.2009)
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Hierarchical Protein Folding: Asymmetric Unfolding of an Insulin Analogue Lacking the A7−B7 Interchain Disulfide Bridge
Hua, Qing-Xin, Nakagawa, Satoe H, Jia, Wenhua, Hu, Shi-Quan, Chu, Ying-Chi, Katsoyannis, Panayotis G, Weiss, Michael A
Published in Biochemistry (Easton) (16.10.2001)
Published in Biochemistry (Easton) (16.10.2001)
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