Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
Israelson, Adrian, Ditsworth, Dara, Sun, Shuying, Song, SungWon, Liang, Jason, Hruska-Plochan, Marian, McAlonis-Downes, Melissa, Abu-Hamad, Salah, Zoltsman, Guy, Shani, Tom, Maldonado, Marcus, Bui, Anh, Navarro, Michael, Zhou, Huilin, Marsala, Martin, Kaspar, Brian K., Da Cruz, Sandrine, Cleveland, Don W.
Published in Neuron (Cambridge, Mass.) (08.04.2015)
Published in Neuron (Cambridge, Mass.) (08.04.2015)
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Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Frakes, Ashley E., Ferraiuolo, Laura, Haidet-Phillips, Amanda M., Schmelzer, Leah, Braun, Lyndsey, Miranda, Carlos J., Ladner, Katherine J., Bevan, Adam K., Foust, Kevin D., Godbout, Jonathan P., Popovich, Phillip G., Guttridge, Denis C., Kaspar, Brian K.
Published in Neuron (Cambridge, Mass.) (05.03.2014)
Published in Neuron (Cambridge, Mass.) (05.03.2014)
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Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
Kaspar, Brian K, Foust, Kevin D, Nurre, Emily, Montgomery, Chrystal L, Hernandez, Anna, Chan, Curtis M
Published in Nature biotechnology (01.01.2009)
Published in Nature biotechnology (01.01.2009)
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Improving Single Injection CSF Delivery of AAV9-mediated Gene Therapy for SMA: A Dose–response Study in Mice and Nonhuman Primates
Meyer, Kathrin, Ferraiuolo, Laura, Schmelzer, Leah, Braun, Lyndsey, McGovern, Vicki, Likhite, Shibi, Michels, Olivia, Govoni, Alessandra, Fitzgerald, Julie, Morales, Pablo, Foust, Kevin D, Mendell, Jerry R, Burghes, Arthur H M, Kaspar, Brian K
Published in Molecular therapy (01.03.2015)
Published in Molecular therapy (01.03.2015)
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Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Sun, Shuying, Sun, Ying, Ling, Shuo-Chien, Ferraiuolo, Laura, McAlonis-Downes, Melissa, Zou, Yiyang, Drenner, Kevin, Wang, Yin, Ditsworth, Dara, Tokunaga, Seiya, Kopelevich, Alex, Kaspar, Brian K., Lagier-Tourenne, Clotilde, Cleveland, Don W.
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
Meyer, Kathrin, Ferraiuolo, Laura, Miranda, Carlos J., Likhite, Shibi, McElroy, Sohyun, Renusch, Samantha, Ditsworth, Dara, Lagier-Tourenne, Clotilde, Smith, Richard A., Ravits, John, Burghes, Arthur H., Shaw, Pamela J., Cleveland, Don W., Kolb, Stephen J., Kaspar, Brian K.
Published in Proceedings of the National Academy of Sciences - PNAS (14.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (14.01.2014)
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The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J
Published in The EMBO journal (01.08.2016)
Published in The EMBO journal (01.08.2016)
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A role for glia in the progression of Rett’s syndrome
Lioy, Daniel T., Garg, Saurabh K., Monaghan, Caitlin E., Raber, Jacob, Foust, Kevin D., Kaspar, Brian K., Hirrlinger, Petra G., Kirchhoff, Frank, Bissonnette, John M., Ballas, Nurit, Mandel, Gail
Published in Nature (London) (28.07.2011)
Published in Nature (London) (28.07.2011)
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Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
Ferraiuolo, Laura, Meyer, Kathrin, Sherwood, Thomas W., Vick, Jonathan, Likhite, Shibi, Frakes, Ashley, Miranda, Carlos J., Braun, Lyndsey, Heath, Paul R., Pineda, Ricardo, Beattie, Christine E., Shaw, Pamela J., Askwith, Candice C., McTigue, Dana, Kaspar, Brian K.
Published in Proceedings of the National Academy of Sciences - PNAS (18.10.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (18.10.2016)
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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Kaspar, Brian K, Haidet-Phillips, Amanda M, Hester, Mark E, Miranda, Carlos J, Meyer, Kathrin, Braun, Lyndsey, Frakes, Ashley, Song, SungWon, Likhite, Shibi, Murtha, Matthew J, Foust, Kevin D, Rao, Meghan, Eagle, Amy, Kammesheidt, Anja, Christensen, Ashley, Mendell, Jerry R, Burghes, Arthur H M
Published in Nature biotechnology (10.08.2011)
Published in Nature biotechnology (10.08.2011)
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Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome
Garg, Saurabh K, Lioy, Daniel T, Cheval, Hélène, McGann, James C, Bissonnette, John M, Murtha, Matthew J, Foust, Kevin D, Kaspar, Brian K, Bird, Adrian, Mandel, Gail
Published in The Journal of neuroscience (21.08.2013)
Published in The Journal of neuroscience (21.08.2013)
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Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS
Foust, Kevin D, Salazar, Desirée L, Likhite, Shibi, Ferraiuolo, Laura, Ditsworth, Dara, Ilieva, Hristelina, Meyer, Kathrin, Schmelzer, Leah, Braun, Lyndsey, Cleveland, Don W, Kaspar, Brian K
Published in Molecular therapy (01.12.2013)
Published in Molecular therapy (01.12.2013)
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A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy
Mendell, Jerry R, Sahenk, Zarife, Malik, Vinod, Gomez, Ana M, Flanigan, Kevin M, Lowes, Linda P, Alfano, Lindsay N, Berry, Katherine, Meadows, Eric, Lewis, Sarah, Braun, Lyndsey, Shontz, Kim, Rouhana, Maria, Clark, Kelly Reed, Rosales, Xiomara Q, Al-Zaidy, Samiah, Govoni, Alessandra, Rodino-Klapac, Louise R, Hogan, Mark J, Kaspar, Brian K
Published in Molecular therapy (01.01.2015)
Published in Molecular therapy (01.01.2015)
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Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis
Song, SungWon, Miranda, Carlos J, Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E, Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K, Foust, Kevin D, McConnell, Michael J, Walker, Christopher M, Kaspar, Brian K
Published in Nature medicine (01.04.2016)
Published in Nature medicine (01.04.2016)
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NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes
Brulet, Rebecca, Matsuda, Taito, Zhang, Ling, Miranda, Carlos, Giacca, Mauro, Kaspar, Brian K., Nakashima, Kinichi, Hsieh, Jenny
Published in Stem cell reports (06.06.2017)
Published in Stem cell reports (06.06.2017)
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Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates
Samaranch, Lluis, Salegio, Ernesto A, San Sebastian, Waldy, Kells, Adrian P, Foust, Kevin D, Bringas, John R, Lamarre, Clementine, Forsayeth, John, Kaspar, Brian K, Bankiewicz, Krystof S
Published in Human gene therapy (01.04.2012)
Published in Human gene therapy (01.04.2012)
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Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice
Mendonça, Liliana S, Nóbrega, Clévio, Hirai, Hirokazu, Kaspar, Brian K, Pereira de Almeida, Luís
Published in Brain (London, England : 1878) (01.02.2015)
Published in Brain (London, England : 1878) (01.02.2015)
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Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomes
Mendell, Jerry R., Sahenk, Zarife, Al-Zaidy, Samiah, Rodino-Klapac, Louise R., Lowes, Linda P., Alfano, Lindsay N., Berry, Katherine, Miller, Natalie, Yalvac, Mehmet, Dvorchik, Igor, Moore-Clingenpeel, Melissa, Flanigan, Kevin M., Church, Kathleen, Shontz, Kim, Curry, Choumpree, Lewis, Sarah, McColly, Markus, Hogan, Mark J., Kaspar, Brian K.
Published in Molecular therapy (05.04.2017)
Published in Molecular therapy (05.04.2017)
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