Search Results - "KASIBHATLA SHAILAJA" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer

The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer

by Friboulet, Luc, Li, Nanxin, Katayama, Ryohei, Lee, Christian C, Gainor, Justin F, Crystal, Adam S, Michellys, Pierre-Yves, Awad, Mark M, Yanagitani, Noriko, Kim, Sungjoon, Pferdekamper, AnneMarie C, Li, Jie, Kasibhatla, Shailaja, Sun, Frank, Sun, Xiuying, Hua, Su, McNamara, Peter, Mahmood, Sidra, Lockerman, Elizabeth L, Fujita, Naoya, Nishio, Makoto, Harris, Jennifer L, Shaw, Alice T, Engelman, Jeffrey A
Published in Cancer discovery (01.06.2014)

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

by Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Van Phung, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Xu Wu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)

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EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

by Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew J, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei-Ting, Pferdekamper, AnneMarie Culazzo, Lockerman, Elizabeth L, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, DiDonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, McNeill, Matthew, Epple, Robert, Marsilje, Thomas H, Pathan, Nuzhat, Engelman, Jeffrey A, Michellys, Pierre-Yves, McNamara, Peter, Harris, Jennifer, Bender, Steven, Kasibhatla, Shailaja
Published in Cancer research (Chicago, Ill.) (15.03.2016)

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Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

by Wang, Hui Qin, Halilovic, Ensar, Li, Xiaoyan, Liang, Jinsheng, Cao, Yichen, Rakiec, Daniel P, Ruddy, David A, Jeay, Sebastien, Wuerthner, Jens U, Timple, Noelito, Kasibhatla, Shailaja, Li, Nanxin, Williams, Juliet A, Sellers, William R, Huang, Alan, Li, Fang
Published in eLife (20.04.2017)

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Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships of N-Alkyl Substituted Pyrrole Fused at the 7,8-Positions

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships of N-Alkyl Substituted Pyrrole Fused at the 7,8-Positions

by Kemnitzer, William, Drewe, John, Jiang, Songchun, Zhang, Hong, Crogan-Grundy, Candace, Labreque, Denis, Bubenick, Monica, Attardo, Giorgio, Denis, Real, Lamothe, Serge, Gourdeau, Henriette, Tseng, Ben, Kasibhatla, Shailaja, Cai, Sui Xiong
Published in Journal of medicinal chemistry (14.02.2008)

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Discovery and Structure−Activity Relationship of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents

Discovery and Structure−Activity Relationship of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents

by Zhang, Han-Zhong, Kasibhatla, Shailaja, Kuemmerle, Jared, Kemnitzer, William, Ollis-Mason, Kristin, Qiu, Ling, Crogan-Grundy, Candace, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Journal of medicinal chemistry (11.08.2005)

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A Chemical Genetics Approach for the Discovery of Apoptosis Inducers:From Phenotypic Cell Based HTS Assay and Structure-Activity Relationship Studies, to Identification of Potential Anticancer Agents and Molecular Targets

A Chemical Genetics Approach for the Discovery of Apoptosis Inducers:From Phenotypic Cell Based HTS Assay and Structure-Activity Relationship Studies, to Identification of Potential Anticancer Agents and Molecular Targets

by SUI XIONG CAI, DREWE, John, KASIBHATLA, Shailaja
Published in Current medicinal chemistry (01.09.2006)

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Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents

Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents

by Gourdeau, Henriette, Leblond, Lorraine, Hamelin, Bettina, Desputeau, Clemence, Dong, Kelly, Kianicka, Irenej, Custeau, Dominique, Boudreau, Chantal, Geerts, Lilianne, Cai, Sui-Xiong, Drewe, John, Labrecque, Denis, Kasibhatla, Shailaja, Tseng, Ben
Published in Molecular cancer therapeutics (01.11.2004)

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Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

by ZHANG, Han-Zhong, KASIBHATLA, Shailaja, YAN WANG, HERICH, John, GUASTELLA, John, BEN TSENG, DREWE, John, SUI XIONG CAI
Published in Bioorganic & medicinal chemistry (15.01.2004)

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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions

by KEMNITZER, William, KASIBHATLA, Shailaja, VAILLANCOURT, Louis, CHARRON, Sylvie, DODD, Jennifer, ATTARDO, Giorgio, LABRECQUE, Denis, LAMOTHE, Serge, GOURDEAU, Henriette, TSENG, Ben, DREWE, John, SUI XIONG CAI, SONGCHUN JIANG, HONG ZHANG, JIANGHONG ZHAO, SHAOJUAN JIA, LIFEN XU, CROGAN-GRUNDY, Candace, DENIS, Réal, BARRIAULT, Nancy
Published in Bioorganic & medicinal chemistry letters (01.11.2005)

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A Role for Transferrin Receptor in Triggering Apoptosis When Targeted with Gambogic Acid

A Role for Transferrin Receptor in Triggering Apoptosis When Targeted with Gambogic Acid

by Kasibhatla, Shailaja, Jessen, Katayoun A, Maliartchouk, Sergei, Wang, Jean Yu, English, Nicole M, Drewe, John, Qiu, Ling, Archer, Shannon P, Ponce, Anthony E, Sirisoma, Nilantha, Jiang, Songchun, Zhang, Han-Zhong, Gehlsen, Kurt R, Cai, Sui Xiong, Green, Douglas R, Tseng, Ben
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2005)

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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell-and caspase-based HTS assay. Part 5: Modifications of the 2-and 3-positions

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell-and caspase-based HTS assay. Part 5: Modifications of the 2-and 3-positions

by KEMNITZER, William, SONGCHUN JIANG, GOURDEAU, Henriette, TSENG, Ben, DREWE, John, SUI XIONG CAI, YAN WANG, KASIBHATLA, Shailaja, CROGAN-GRUNDY, Candace, BUBENIK, Monica, LABRECQUE, Denis, DENIS, Real, LAMOTHE, Serge, ATTARDO, Giorgio
Published in Bioorganic & medicinal chemistry (15.01.2008)

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Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell-and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1-and 3-positions

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell-and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1-and 3-positions

by KEMNITZER, William, KUEMMERLE, Jared, SONGCHUN JIANG, ZHANG, Han-Zhong, SIRISOMA, Nilantha, KASIBHATLA, Shailaja, CROGAN-GRUNDY, Candace, TSENG, Ben, DREWE, John, SUI XIONG CAI
Published in Bioorganic & medicinal chemistry letters (01.12.2008)

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Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity

Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity

by Kasibhatla, Shailaja, Gourdeau, Henriette, Meerovitch, Karen, Drewe, John, Reddy, Sanjeeva, Qiu, Ling, Zhang, Hong, Bergeron, Frederick, Bouffard, David, Yang, Quan, Herich, John, Lamothe, Serge, Cai, Sui Xiong, Tseng, Ben
Published in Molecular cancer therapeutics (01.11.2004)

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Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2( 1H )-quinolinones through a Myc-dependent pathway

Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2( 1H )-quinolinones through a Myc-dependent pathway

by Claassen, Gisela, Brin, Elena, Crogan-Grundy, Candace, Vaillancourt, Mei Ting, Zhang, Han Zhong, Cai, Sui Xiong, Drewe, John, Tseng, Ben, Kasibhatla, Shailaja
Published in Cancer letters (18.02.2009)

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Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring

Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring

by Sirisoma, Nilantha, Pervin, Azra, Zhang, Hong, Jiang, Songchun, Adam Willardsen, J., Anderson, Mark B., Mather, Gary, Pleiman, Christopher M., Kasibhatla, Shailaja, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry letters (01.04.2010)

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Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay

Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay

by Zhang, Han-Zhong, Drewe, John, Tseng, Ben, Kasibhatla, Shailaja, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry (01.07.2004)

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PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models

by Ellwood-Yen, Katharine, Keilhack, Heike, Kunii, Kaiko, Dolinski, Brian, Connor, Yamicia, Hu, Kun, Nagashima, Kumiko, O'Hare, Erin, Erkul, Yusuf, Di Bacco, Alessandra, Gargano, Diana, Shomer, Nirah H, Angagaw, Minilik, Leccese, Erica, Andrade, Paula, Hurd, Melissa, Shin, Myung K, Vogt, Thomas F, Northrup, Alan, Bobkova, Ekaterina V, Kasibhatla, Shailaja, Bronson, Roderick T, Scott, Martin L, Draetta, Giulio, Richon, Victoria, Kohl, Nancy, Blume-Jensen, Peter, Andersen, Jannik N, Kraus, Manfred
Published in Cancer research (Chicago, Ill.) (15.04.2011)

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Partial Cleavage of RasGAP by Caspases Is Required for Cell Survival in Mild Stress Conditions

Partial Cleavage of RasGAP by Caspases Is Required for Cell Survival in Mild Stress Conditions

by Yang, Jiang-Yan, Michod, David, Walicki, Joël, Murphy, Brona M., Kasibhatla, Shailaja, Martin, Seamus J., Widmann, Christian
Published in Molecular and Cellular Biology (01.12.2004)

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Discovery of Substituted N-Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay

Discovery of Substituted N-Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay

by Cai, Sui Xiong, Nguyen, Bao, Jia, Shaojuan, Herich, John, Guastella, John, Reddy, Sanjeeva, Tseng, Ben, Drewe, John, Kasibhatla, Shailaja
Published in Journal of medicinal chemistry (05.06.2003)

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