2-Acyl-tetrahydroisoquinoline-3-carboxylic Acids: Lead Compounds with Triple Actions, Peroxisome Proliferator-Activated Receptor α/γ Agonist and Protein-Tyrosine Phosphatase 1B Inhibitory Activities
Otake, Kazuya, Azukizawa, Satoru, Takahashi, Kenji, Fukui, Masaki, Shibabayashi, Michiko, Kamemoto, Hikaru, Kasai, Masayasu, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (01.07.2011)
Published in Chemical & pharmaceutical bulletin (01.07.2011)
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Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: Indoline-Based Sulfamide Derivatives with Low Lipophilicity and Protein Binding Ratio
Takahashi, Kenji, Ohta, Masaru, Shoji, Yoshimichi, Kasai, Masayasu, Kunishiro, Kazuyoshi, Miike, Tomohiro, Kanda, Mamoru, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (01.08.2010)
Published in Chemical & pharmaceutical bulletin (01.08.2010)
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A Novel Series of (S)-2,7-Substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acids: Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists with Protein-Tyrosine Phosphatase 1B Inhibitory Activity
Otake, Kazuya, Azukizawa, Satoru, Fukui, Masaki, Shibabayashi, Michiko, Kamemoto, Hikaru, Miike, Tomohiro, Kunishiro, Kazuyoshi, Kasai, Masayasu, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (2011)
Published in Chemical & pharmaceutical bulletin (2011)
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Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation
Ohta, Masaru, Takahashi, Kenji, Kasai, Masayasu, Shoji, Yoshimichi, Kunishiro, Kazuyoshi, Miike, Tomohiro, Kanda, Mamoru, Mukai, Chisato, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (01.08.2010)
Published in Chemical & pharmaceutical bulletin (01.08.2010)
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Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists
Azukizawa, Satoru, Kasai, Masayasu, Takahashi, Kenji, Miike, Tomohiro, Kunishiro, Kazuyoshi, Kanda, Mamoru, Mukai, Chisato, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (01.03.2008)
Published in Chemical & pharmaceutical bulletin (01.03.2008)
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Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPAR.GAMMA. Agonists
Azukizawa, Satoru, Kasai, Masayasu, Takahashi, Kenji, Miike, Tomohiro, Kunishiro, Kazuyoshi, Kanda, Mamoru, Mukai, Chisato, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (2008)
Published in Chemical & pharmaceutical bulletin (2008)
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Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: Indoline-Based Sulfamide Derivatives with Low Lipophilicity and Protein Binding Ratio
Kenji TAKAHASHI, Masaru OHTA, Yoshimichi SHOJI, Masayasu KASAI, Kazuyoshi KUNISHIRO, Tomohiro MIIKE, Mamoru KANDA, Hiroaki SHIRAHASE
Published in Chemical & Pharmaceutical Bulletin (2010)
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Published in Chemical & Pharmaceutical Bulletin (2010)
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Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation
Masaru OHTAa, b, Kenji TAKAHASHIa, Masayasu KASAIa, Yoshimichi SHOJIa, Kazuyoshi KUNISHIROa, Tomohiro MIIKEa, Mamoru KANDAa, Chisato MUKAIb, Hiroaki SHIRAHASEa
Published in Chemical & Pharmaceutical Bulletin (2010)
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Published in Chemical & Pharmaceutical Bulletin (2010)
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A Novel Series of Thromboxane A2 Synthetase Inhibitors with Free Radical Scavenging and Anti-peroxidative Activities
KAMIYA, Shoji, SHIRAHASE, Hiroaki, NAKAMURA, Shohei, KANDA, Mamoru, MATSUI, Hiroshi, YOSHIMI, Akihisa, KASAI, Masayasu, TAKAHASHI, Kenji, KURAHASHI, Kazuyoshi
Published in Chemical & pharmaceutical bulletin (01.05.2001)
Published in Chemical & pharmaceutical bulletin (01.05.2001)
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Bioavailable Acyl-CoA : Cholesterol Acyltransferase Inhibitor with Anti-peroxidative Activity : Synthesis and Biological Activity of Novel Indolinyl Amide and Urea Derivatives
KAMIYA, Shoji, SHIRAHASE, Hiroaki, YOSHIMI, Akihisa, NAKAMURA, Shohei, KANDA, Mamoru, MATSUI, Hiroshi, KASAI, Masayasu, TAKAHASHI, Kenji, KURAHASHI, Kazuyoshi
Published in Chemical & pharmaceutical bulletin (01.06.2000)
Published in Chemical & pharmaceutical bulletin (01.06.2000)
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Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: Peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition
Otake, Kazuya, Azukizawa, Satoru, Fukui, Masaki, Kunishiro, Kazuyoshi, Kamemoto, Hikaru, Kanda, Mamoru, Miike, Tomohiro, Kasai, Masayasu, Shirahase, Hiroaki
Published in Bioorganic & medicinal chemistry (15.01.2012)
Published in Bioorganic & medicinal chemistry (15.01.2012)
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AS-924, a Novel Orally Active Bifunctional Prodrug of Ceftizoxime. Synthesis and Relationship between Physicochemical Properties and Oral Absorption
KASAI, Masayasu, HATANO, Satoru, KITAGAWA, Meiko, YOSHIMI, Akihisa, NISHIMURA, Ken-ichi, MORI, Nobuhiro, SAKAI, Atsushi, SUGIHARA, Taisuke
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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NOVEL ANTICANCER AGENT
KASAI MASAYASU, YOSHIMURA YOSHINOBU, TAKEDA SHIGEMITSU, SHOJI YOSHIMICHI
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
Patent
Novel Indoline-Based Acyl-CoA:Cholesterol Acyltransferase Inhibitor with Antiperoxidative Activity: Improvement of Physicochemical Properties and Biological Activities by Introduction of Carboxylic Acid
Takahashi, Kenji, Kasai, Masayasu, Ohta, Masaru, Shoji, Yoshimichi, Kunishiro, Kazuyoshi, Kanda, Mamoru, Kurahashi, Kazuyoshi, Shirahase, Hiroaki
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
AS-924, a Novel Bifunctional Prodrug of Ceftioxime
KASAI, MASAYASU, HATANO, SATORU, KITAGAWA, MEIKO, YOSHIMI, AKIHISA, SHIRAHASE, HIROAKI, NISHIMURA, KEN-ICHI, KAKEYA, NOBUHARU
Published in Journal of antibiotics (1999)
Published in Journal of antibiotics (1999)
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NOVEL ANTICANCER AGENT
YOSHIMURA, YOSHINOBU, KASAI, MASAYASU, TAKEDA, SHIGEMITSU, SHOJI, YOSHIMICHI
Year of Publication 17.12.2015
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Year of Publication 17.12.2015
Patent
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: Peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition: Symposium-in-Print: Chemical Proteomics
OTAKE, Kazuya, AZUKIZAWA, Satoru, FUKUI, Masaki, KUNISHIRO, Kazuyoshi, KAMEMOTO, Hikaru, KANDA, Mamoru, MIIKE, Tomohiro, KASAI, Masayasu, SHIRAHASE, Hiroaki
Published in Bioorganic & medicinal chemistry (2012)
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Published in Bioorganic & medicinal chemistry (2012)
Journal Article
2-Acyl-tetrahydroisoquinoline-3-carboxylic Acids
Otake, Kazuya, Azukizawa, Satoru, Takahashi, Kenji, Fukui, Masaki, Shibabayashi, Michiko, Kamemoto, Hikaru, Kasai, Masayasu, Shirahase, Hiroaki
Published in Chemical & pharmaceutical bulletin (01.07.2011)
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Published in Chemical & pharmaceutical bulletin (01.07.2011)
Journal Article
Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities
Shoji, Yoshimichi, Takahashi, Kenji, Ohta, Masaru, Kasai, Masayasu, Kunishiro, Kazuyoshi, Kanda, Mamoru, Yogai, Satoko, Takeuchi, Yasuo, Shirahase, Hiroaki
Published in Bioorganic & medicinal chemistry (15.08.2009)
Published in Bioorganic & medicinal chemistry (15.08.2009)
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