Discovery of Novel Indazole Derivatives as Orally Available β3‑Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects
Wada, Yasuhiro, Nakano, Seiji, Morimoto, Akifumi, Kasahara, Ken-ichi, Hayashi, Takahiko, Takada, Yoshio, Suzuki, Hiroko, Niwa-Sakai, Michiko, Ohashi, Shigeki, Mori, Mutsuhiro, Hirokawa, Takatsugu, Shuto, Satoshi
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats
Sakai, Takumi, Kasahara, Ken-ichi, Tomita, Ken-ichi, Ikegaki, Ichiro, Kuriyama, Hiroshi
Published in European journal of pharmacology (30.01.2013)
Published in European journal of pharmacology (30.01.2013)
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The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats
Kasahara, Ken-ichi, Hashimoto, Shinji, Hattori, Tsuyoshi, Kawasaki, Koh, Tsujita, Ryuichi, Nakazono, Osamu, Takao, Katsuyuki, Kawakubo, Hiromu, Nagatani, Tadashi
Published in Journal of pharmacological sciences (01.01.2015)
Published in Journal of pharmacological sciences (01.01.2015)
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Piezo1 expression increases in rat bladder after partial bladder outlet obstruction
Michishita, Mai, Yano, Kazuo, Tomita, Ken-ichi, Matsuzaki, Osamu, Kasahara, Ken-ichi
Published in Life sciences (1973) (01.12.2016)
Published in Life sciences (1973) (01.12.2016)
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Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3‑Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects
Wada, Yasuhiro, Shirahashi, Hiromitsu, Iwanami, Taisuke, Ogawa, Masami, Nakano, Seiji, Morimoto, Akifumi, Kasahara, Ken-ichi, Tanaka, Eiichi, Takada, Yoshio, Ohashi, Shigeki, Mori, Mutsuhiro, Shuto, Satoshi
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats
Sakai, Takumi, Kasahara, Ken-ichi, Tomita, Ken-ichi, Ikegaki, Ichiro, Kuriyama, Hiroshi
Published in American journal of physiology. Renal physiology (01.04.2013)
Published in American journal of physiology. Renal physiology (01.04.2013)
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SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Morimoto, Akifumi, Kasahara, Ken-ichi, Ohashi, Shigeki, Suzuki, Hiroko, Hayashi, Takahiko, Miyoshi, Shiro
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Mast Cell Accumulation and Degranulation in Rat Bladder with Partial Outlet Obstruction
Michishita, Mai, Tomita, Ken-ichi, Yano, Kazuo, Kasahara, Ken-ichi
Published in Advances in therapy (01.10.2015)
Published in Advances in therapy (01.10.2015)
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Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Morimoto, Akifumi, Kasahara, Ken-ichi, Ohashi, Shigeki, Suzuki, Hiroko, Hayashi, Takahiko, Miyoshi, Shiro
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Thermal and Photochemical Isomerization of Tetraaryl Tetrakis(trifluoromethyl)[4]radialenes
Uno, Hidemitsu, Kasahara, Ken-ichi, Nibu, Nobumasa, Nagaoka, Shin-ichi, Ono, Noboru
Published in Journal of organic chemistry (24.03.2000)
Published in Journal of organic chemistry (24.03.2000)
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MP26-19 DOWNREGULATION OF MONOAMINE OXIDASE A MAY CONTRIBUTE TO DEVELOPMENT OF DETRUSOR HYPER CONTRACTILITY IN URINARY BLADDER WITH PARTIAL BLADDER OUTLET OBSTRUCTION IN RATS
Michishita, Mai, Hattori, Tsuyoshi, Yano, Kazuo, Tomita, Ken-ichi, Kasahara, Ken-ichi
Published in The Journal of urology (01.04.2017)
Published in The Journal of urology (01.04.2017)
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Journal Article
Discovery of Novel Indazole Derivatives as Orally Available beta(3)-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects
Wada, Yasuhiro, Nakano, Seiji, Morimoto, Akifumi, Kasahara, Ken-ichi, Hayashi, Takahiko, Takada, Yoshio, Suzuki, Hiroko, Niwa-Sakai, Michiko, Ohashi, Shigeki, Mori, Mutsuhiro, Hirokawa, Takatsugu, Shuto, Satoshi
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human beta(3)-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects
Wada, Yasuhiro, Shirahashi, Hiromitsu, Iwanami, Taisuke, Ogawa, Masami, Nakano, Seiji, Morirnoto, Akifumi, Kasahara, Ken-ichi, Tanaka, Eiichi, Takada, Yoshio, Ohashi, Shigeki, Mori, Mutsuhiro, Shuto, Satoshi
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Journal Article
Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP1 receptor antagonists for treatment of overactive bladder by core structure replacement
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Morimoto, Akifumi, Kasahara, Ken-ichi, Ohashi, Shigeki, Suzuki, Hiroko, Hayashi, Takahiko, Miyoshi, Shiro
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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Journal Article
Discovery of Novel Indazole Derivatives as Orally Available β 3 -Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects
Wada, Yasuhiro, Nakano, Seiji, Morimoto, Akifumi, Kasahara, Ken-Ichi, Hayashi, Takahiko, Takada, Yoshio, Suzuki, Hiroko, Niwa-Sakai, Michiko, Ohashi, Shigeki, Mori, Mutsuhiro, Hirokawa, Takatsugu, Shuto, Satoshi
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β 3 -Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects
Wada, Yasuhiro, Shirahashi, Hiromitsu, Iwanami, Taisuke, Ogawa, Masami, Nakano, Seiji, Morimoto, Akifumi, Kasahara, Ken-ichi, Tanaka, Eiichi, Takada, Yoshio, Ohashi, Shigeki, Mori, Mutsuhiro, Shuto, Satoshi
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Journal Article