The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates
Oshima, Shinsuke, Karrer, Erik E, Kawato, Yuka, Maeda, Masashi, Fukahori, Hidehiko, Tsujimoto, Susumu, Hirose, Jun, Nakamura, Koji, Marui, Takanori, Takamura, Fujiko, Noto, Takahisa, Chapin, Steven J, Fujii, Yasutomo, Neighbors, Margaret, Viswanathan, Sridhar, Devens, Bruce H, Higashi, Yasuyuki
Published in Transplantation (01.12.2016)
Published in Transplantation (01.12.2016)
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Journal Article
ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution
Oshima, Shinsuke, Karrer, Erik E., Paidhungat, Madan M., Neighbors, Margaret, Chapin, Steven J., Fan, Rong A., Reed, Margaret A., Wu, Kuoting, Wong, Clifford, Chen, Yonghong, Whitlow, Marc, Anderson, Francisco A., Bam, Rujuta A., Zhang, Qian, Larsen, Brent R., Viswanathan, Sridhar, Devens, Bruce H., Bass, Steven H., Higashi, Yasuyuki
Published in Protein engineering, design and selection (01.05.2016)
Published in Protein engineering, design and selection (01.05.2016)
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Journal Article
Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys
Oshima, Shinsuke, Fujii, Yasutomo, Karrer, Erik E., Takamura, Fujiko, Chapin, Steven J., Neighbors, Margaret, Viswanathan, Sridhar, Devens, Bruce H., Higashi, Yasuyuki, Mizuhara, Hidekazu
Published in International immunopharmacology (01.11.2016)
Published in International immunopharmacology (01.11.2016)
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Journal Article
A Phase 1 Dose-Escalation Study of ASP2409, a Selective T-Cell Costimulation Inhibitor, in Stable Rheumatoid Arthritis Patients on Methotrexate Therapy
Zhang, Wenhui, Kernstock, Robert M., Karrer, Erik E., Cohen, Stanley B., Chindalore, Vishala L., Kivitz, Alan J., Blahunka, Paul C., Delgado-Herrera, Leticia, Zeiher, Bernhardt G., Samberg, Nancy L., Garg, Jay P.
Published in Clinical pharmacology in drug development (01.07.2016)
Published in Clinical pharmacology in drug development (01.07.2016)
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of ASP2408, a Potent Selective T-Cell Costimulation Modulator After Single and Multiple Ascending Doses in Healthy Volunteers and RA Patients
Zhu, Tong, Keirns, James, Howieson, Corrie, Kaibara, Atsunori, Goldwater, Ronald, Kivitz, Alan J., Chindalore, Vishala, Cohen, Stanley, Santos, Vicki, Akinlade, Bolanle, Kernstock, Robert, Delgado-Herrera, Leticia, Blahunka, Paul C, Karrer, Erik E., Garg, Jay P., Samberg, Nancy, Zeiher, Bernhardt G.
Published in Clinical pharmacology in drug development (01.09.2016)
Published in Clinical pharmacology in drug development (01.09.2016)
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Journal Article
Cloning of tobacco genes that elicit the hypersensitive response
Karrer, E.E. (Scripps Research Inst., La Jolla, CA (USA)), Beachy, R.N, Holt, C.A
Published in Plant molecular biology (01.03.1998)
Published in Plant molecular biology (01.03.1998)
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In situ isolation of mRNA from individual plant cells: creation of cell-specific cDNA libraries
Karrer, E.E. (The Scripps Research Institute, La Jolla, CA.), Lincoln, J.E, Hogenhout, S, Bennett, A.B, Bostock, R.M, Martineau, B, Lucas, W.J, Gilchrist, D.G, Alexander, D
Published in Proceedings of the National Academy of Sciences - PNAS (25.04.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (25.04.1995)
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Journal Article
IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
PAIDHUNGAT MADAN M, KARRER ERIK E, PUNNONEN JUHA, NEIGHBORS MARGARET, VISWANATHAN SRIDHAR, LARSEN BRENT R, CHAPIN STEVEN J, BASS STEVEN H
Year of Publication 29.09.2010
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Year of Publication 29.09.2010
Patent
Metabolic regulation of rice α‐amylase and sucrose synthase genes in planta
Karrer, Erik E., Rodriguez, Raymond L.
Published in The Plant journal : for cell and molecular biology (01.07.1992)
Published in The Plant journal : for cell and molecular biology (01.07.1992)
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Journal Article
Metabolic regulation of rice alpha-amylase and sucrose synthase genes in planta
Karrer, Erik E., Rodriguez, Raymond L.
Published in The Plant journal : for cell and molecular biology (01.07.1992)
Published in The Plant journal : for cell and molecular biology (01.07.1992)
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Journal Article
IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
ERIK E. KARRER, MARGARET NEIGHBORS, JUHA PUNNONEN, SRIDHAR VISWANATHAN, STEVEN J. CHAPIN, MADAN M. PAIDHUNGAT, BRENT R. LARSEN, STEVEN H. BASS
Year of Publication 24.10.2018
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Year of Publication 24.10.2018
Patent
Immunosuppressive polypeptides and nucleic acids
Karrer, Erik, E, Paidhungat, Madan, M, Viswanathan, Sridhar, Bass, Steven, H, Neighbors, Margaret, Chapin, Steven, J, Larsen, Brent, R, Punnonen, Juha
Year of Publication 15.08.2018
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Year of Publication 15.08.2018
Patent
IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
PAIDHUNGAT, MADAN, M, CHAPIN, STEVEN, J, BASS, STEVEN, H, PUNNONEN, JUHA, VISWANATHAN, SRIDHAR, LARSEN, BRENT, R, KARRER, ERIK, E, NEIGHBORS, MARGARET
Year of Publication 07.12.2015
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Year of Publication 07.12.2015
Patent
IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
PAIDHUNGAT, MADAN, M, CHAPIN, STEVEN, J, BASS, STEVEN, H, PUNNONEN, JUHA, VISWANATHAN, SRIDHAR, LARSEN, BRENT, R, KARRER, ERIK, E, NEIGHBORS, MARGARET
Year of Publication 07.12.2015
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Year of Publication 07.12.2015
Patent
Immunosuppressive polypeptides and nucleic acids
LARSEN, BRENT R, PAIDHUNGAT, MADAN M, BASS, STEVEN H, PUNNONEN, JUHA, VISWANATHAN, SRIDHAR, NEIGHBORS, MARGARET, CHAPIN, STEVEN J, KARRER, ERIK E
Year of Publication 26.11.2015
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Year of Publication 26.11.2015
Patent
Immunosuppressive polypeptides and nucleic acids
PAIDHUNGAT MADAN M, KARRER ERIK E, PUNNONEN JUHA, NEIGHBORS MARGARET, CHAPIN STEVEN J, BASS STEVEN H
Year of Publication 30.07.2013
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Year of Publication 30.07.2013
Patent
Immunosuppressive polypeptides and nucleic acids
PAIDHUNGAT MADAN M, KARRER ERIK E, PUNNONEN JUHA, NEIGHBORS MARGARET, CHAPIN STEVEN J, BASS STEVEN H
Year of Publication 23.07.2013
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Year of Publication 23.07.2013
Patent
Immunosuppressive polypeptides and nucleic acids
PAIDHUNGAT MADAN M, KARRER ERIK E, PUNNONEN JUHA, NEIGHBORS MARGARET, CHAPIN STEVEN J, BASS STEVEN H
Year of Publication 21.05.2013
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Year of Publication 21.05.2013
Patent
IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS
PAIDHUNGAT, MADAN M, LARSEN, BRENT R, BASS, STEVEN H, PUNNONEN, JUHA, VISWANATHAN, SRIDHAR, NEIGHBORS, MARGARET, CHAPIN, STEVEN J, KARRER, ERIK E
Year of Publication 26.05.2015
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Year of Publication 26.05.2015
Patent