The global preclinical antibacterial pipeline
Theuretzbacher, Ursula, Outterson, Kevin, Engel, Aleks, Karlén, Anders
Published in Nature reviews. Microbiology (01.05.2020)
Published in Nature reviews. Microbiology (01.05.2020)
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Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide
Alogheli, Hiba, Olanders, Gustav, Schaal, Wesley, Brandt, Peter, Karlén, Anders
Published in Journal of chemical information and modeling (27.02.2017)
Published in Journal of chemical information and modeling (27.02.2017)
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Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′ O)-methyltransferase
Luzhkov, Victor B., Selisko, Barbara, Nordqvist, Anneli, Peyrane, Frédéric, Decroly, Etienne, Alvarez, Karine, Karlen, Anders, Canard, Bruno, Åqvist, Johan
Published in Bioorganic & medicinal chemistry (15.12.2007)
Published in Bioorganic & medicinal chemistry (15.12.2007)
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Conformational analysis of macrocycles: comparing general and specialized methods
Olanders, Gustav, Alogheli, Hiba, Brandt, Peter, Karlén, Anders
Published in Journal of computer-aided molecular design (01.03.2020)
Published in Journal of computer-aided molecular design (01.03.2020)
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Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods
Svensson, Fredrik, Karlén, Anders, Sköld, Christian
Published in Journal of chemical information and modeling (23.01.2012)
Published in Journal of chemical information and modeling (23.01.2012)
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Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
Olanders, Gustav, Brandt, Peter, Sköld, Christian, Karlén, Anders
Published in Bioorganic & medicinal chemistry (01.11.2021)
Published in Bioorganic & medicinal chemistry (01.11.2021)
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ENABLE: an engine for European antibacterial drug discovery and development
Olliver, Marie, Griestop, Laura, Hughes, Diarmaid, Belfrage, Anna Karin, Gising, Johan, Baranczewski, Pawel, Vingsbo Lundberg, Carina, Karlén, Anders
Published in Nature reviews. Drug discovery (01.06.2021)
Published in Nature reviews. Drug discovery (01.06.2021)
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Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
Benediktsdottir, Andrea, Lu, Lu, Cao, Sha, Zamaratski, Edouard, Karlén, Anders, Mowbray, Sherry L., Hughes, Diarmaid, Sandström, Anja
Published in European journal of medicinal chemistry (15.11.2021)
Published in European journal of medicinal chemistry (15.11.2021)
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Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Gising, Johan, Nilsson, Mikael T, Odell, Luke R, Yahiaoui, Samir, Lindh, Martin, Iyer, Harini, Sinha, Achyut M, Srinivasa, Bachally R, Larhed, Mats, Mowbray, Sherry L, Karlén, Anders
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
Benediktsdottir, Andrea, Sooriyaarachchi, Sanjeewani, Cao, Sha, Ottosson, Nina E., Lindström, Stefan, Lundgren, Bo, Kloditz, Katharina, Lola, Daina, Bobileva, Olga, Loza, Einars, Hughes, Diarmaid, Jones, T. Alwyn, Mowbray, Sherry L., Zamaratski, Edouard, Sandström, Anja, Karlén, Anders
Published in European journal of medicinal chemistry (15.11.2024)
Published in European journal of medicinal chemistry (15.11.2024)
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Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket
Gising, Johan, Belfrage, Anna Karin, Alogheli, Hiba, Ehrenberg, Angelica, Åkerblom, Eva, Svensson, Richard, Artursson, Per, Karlén, Anders, Danielson, U. Helena, Larhed, Mats, Sandström, Anja
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data
Lindh, Martin, Svensson, Fredrik, Schaal, Wesley, Zhang, Jin, Sköld, Christian, Brandt, Peter, Karlén, Anders
Published in Journal of chemical information and modeling (23.02.2015)
Published in Journal of chemical information and modeling (23.02.2015)
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Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Inhibitors
Nordqvist, Anneli, Björkelid, Christofer, Andaloussi, Mounir, Jansson, Anna M, Mowbray, Sherry L, Karlén, Anders, Larhed, Mats
Published in Journal of organic chemistry (04.11.2011)
Published in Journal of organic chemistry (04.11.2011)
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Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis
Andersson, Hanna, Demaegdt, Heidi, Johnsson, Anders, Vauquelin, Georges, Lindeberg, Gunnar, Hallberg, Mathias, Erdélyi, Máté, Karlén, Anders, Hallberg, Anders
Published in Journal of medicinal chemistry (09.06.2011)
Published in Journal of medicinal chemistry (09.06.2011)
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
Huseby, Douglas L, Cao, Sha, Zamaratski, Edouard, Sooriyaarachchi, Sanjeewani, Ahmad, Shabbir, Bergfors, Terese, Krasnova, Laura, Pelss, Juris, Ikaunieks, Martins, Loza, Einars, Katkevics, Martins, Bobileva, Olga, Cirule, Helena, Gukalova, Baiba, Grinberga, Solveiga, Backlund, Maria, Simoff, Ivailo, Leber, Anna T, Berruga-Fernández, Talía, Antonov, Dmitry, Konda, Vivekananda R, Lindström, Stefan, Olanders, Gustav, Brandt, Peter, Baranczewski, Pawel, Vingsbo Lundberg, Carina, Liepinsh, Edgars, Suna, Edgars, Jones, T Alwyn, Mowbray, Sherry L, Hughes, Diarmaid, Karlén, Anders
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2024)
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Disulfide Cyclized Tripeptide Analogues of Angiotensin IV as Potent and Selective Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)
Andersson, Hanna, Demaegdt, Heidi, Vauquelin, Georges, Lindeberg, Gunnar, Karlén, Anders, Hallberg, Mathias, Erdélyi, Máté, Hallberg, Anders
Published in Journal of medicinal chemistry (25.11.2010)
Published in Journal of medicinal chemistry (25.11.2010)
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Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase
Andaloussi, Mounir, Henriksson, Lena M, Wiȩckowska, Anna, Lindh, Martin, Björkelid, Christofer, Larsson, Anna M, Suresh, Surisetti, Iyer, Harini, Srinivasa, Bachally R, Bergfors, Terese, Unge, Torsten, Mowbray, Sherry L, Larhed, Mats, Jones, T. Alwyn, Karlén, Anders
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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