Search Results - "KARL MIRANDA" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The Discovery of N‑(1-Methyl-5-(trifluoromethyl)‑1H‑pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)‑1H‑indole-1-carboxamide (Acrizanib), a VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

The Discovery of N‑(1-Methyl-5-(trifluoromethyl)‑1H‑pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)‑1H‑indole-1-carboxamide (Acrizanib), a VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

by Adams, Christopher M, Anderson, Karen, Artman, Gerald, Bizec, Jean-Claude, Cepeda, Rosemarie, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo A, Hosagrahara, Vinayak P, Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Lee, Wendy, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik L, Miranda, Karl, Peng, Yao, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy M, Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun, Zhang, Yiqin
Published in Journal of medicinal chemistry (22.02.2018)

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Journal Article

Discovery of Oral VEGFR‑2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Discovery of Oral VEGFR‑2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

by Meredith, Erik L, Mainolfi, Nello, Poor, Stephen, Qiu, Yubin, Miranda, Karl, Powers, James, Liu, Donglei, Ma, Fupeng, Solovay, Catherine, Rao, Chang, Johnson, Leland, Ji, Nan, Artman, Gerald, Hardegger, Leo, Hanks, Shawn, Shen, Siyuan, Woolfenden, Amber, Fassbender, Elizabeth, Sivak, Jeremy M, Zhang, Yiqin, Long, Debby, Cepeda, Rosemarie, Liu, Fang, Hosagrahara, Vinayak P, Lee, Wendy, Tarsa, Peter, Anderson, Karen, Elliott, Jason, Jaffee, Bruce
Published in Journal of medicinal chemistry (10.12.2015)

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Journal Article

The Discovery of N -(1-Methyl-5-(trifluoromethyl)-1 H -pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1 H -indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

The Discovery of N -(1-Methyl-5-(trifluoromethyl)-1 H -pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1 H -indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

by Adams, Christopher M., Anderson, Karen, Artman, Gerald, Bizec, Jean-Claude, Cepeda, Rosemarie, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo A., Hosagrahara, Vinayak P., Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Lee, Wendy, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik L., Miranda, Karl, Peng, Yao, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy M., Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun, Zhang, Yiqin
Published in Journal of medicinal chemistry (22.02.2018)

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Journal Article

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

by Monovich, Lauren, Vega, Richard B., Meredith, Erik, Miranda, Karl, Rao, Chang, Capparelli, Michael, Lemon, Douglas D., Phan, Dillon, Koch, Keith A., Chapo, Joseph A., Hood, David B., McKinsey, Timothy A.
Published in FEBS letters (05.02.2010)

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Journal Article

Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

by Meredith, Erik L, Ardayfio, Ophelia, Beattie, Kimberly, Dobler, Markus R, Enyedy, Istvan, Gaul, Christoph, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith, Lee, Wendy, Lehmann, HansJoerg, McKinsey, Timothy A, Miranda, Karl, Pagratis, Nikos, Pancost, Margaret, Patnaik, Anup, Phan, Dillon, Plato, Craig, Qian, Ming, Rajaraman, Vasumathy, Rao, Chang, Rozhitskaya, Olga, Ruppen, Thomas, Shi, Jie, Siska, Sarah J, Springer, Clayton, van Eis, Maurice, Vega, Richard B, von Matt, Anette, Yang, Lihua, Yoon, Taeyoung, Zhang, Ji-Hu, Zhu, Na, Monovich, Lauren G
Published in Journal of medicinal chemistry (12.08.2010)

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

by Meredith, Erik L, Ksander, Gary, Monovich, Lauren G, Papillon, Julien P. N, Liu, Qian, Miranda, Karl, Morris, Patrick, Rao, Chang, Burgis, Robin, Capparelli, Michael, Hu, Qi-Ying, Singh, Alok, Rigel, Dean F, Jeng, Arco Y, Beil, Michael, Fu, Fumin, Hu, Chii-Whei, LaSala, Daniel
Published in ACS medicinal chemistry letters (12.12.2013)

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Journal Article

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

by Meredith, Erik L, Beattie, Kimberly, Burgis, Robin, Capparelli, Michael, Chapo, Joseph, DiPietro, Lucian, Gamber, Gabriel, Enyedy, Istvan, Hood, David B, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith A, Lee, Wendy, Lemon, Douglas D, McKinsey, Timothy A, Miranda, Karl, Pagratis, Nikos, Phan, Dillon, Plato, Craig, Rao, Chang, Rozhitskaya, Olga, Soldermann, Nicolas, Springer, Clayton, van Eis, Maurice, Vega, Richard B, Yan, Wanlin, Zhu, Qingming, Monovich, Lauren G
Published in Journal of medicinal chemistry (12.08.2010)

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Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives

Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives

by Robins, Morris J, Miranda, Karl, Rajwanshi, Vivek K, Peterson, Matt A, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan
Published in Journal of medicinal chemistry (12.01.2006)

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Journal Article

Synthesis and Biological Evaluation of 3,3-Difluoropyridine-2,4(1H,3H)-dione and 3-Deaza-3-fluorouracil Base and Nucleoside Derivatives

Synthesis and Biological Evaluation of 3,3-Difluoropyridine-2,4(1H,3H)-dione and 3-Deaza-3-fluorouracil Base and Nucleoside Derivatives

by Robins, Morris J, Yang, Hong, Miranda, Karl, Peterson, Matt A, Clercq, Erik De, Balzarini, Jan
Published in Journal of medicinal chemistry (14.05.2009)

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Journal Article

Synthesis and Antiviral Evaluation of 6-(Alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one Nucleosides and Analogues with Ethynyl, Ethenyl, and Ethyl Spacers at C6 of the Furopyrimidine Core

Synthesis and Antiviral Evaluation of 6-(Alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one Nucleosides and Analogues with Ethynyl, Ethenyl, and Ethyl Spacers at C6 of the Furopyrimidine Core

by Robins, Morris J, Nowak, Ireneusz, Rajwanshi, Vivek K, Miranda, Karl, Cannon, John F, Peterson, Matt A, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan
Published in Journal of medicinal chemistry (09.08.2007)

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Journal Article

SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS

SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS

by DUMAS, JACQUES, SMITH, ROGER, MIRANDA, KARL, LEE, WENDY, WANG, GAN
Year of Publication 07.04.2015

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Patent

Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders

Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders

by DUMAS, JACQUES, SMITH, ROGER, MIRANDA, KARL, LEE, WENDY, WANG, GAN
Year of Publication 21.05.2014

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Patent

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

by ELLIOTT, Jason Matthew, POWERS, James J, JI, Nan, ARTMAN III, Gerald David, MA, Fupeng, RAO, Chang, MAINOLFI, Nello, LIU, Donglei, MIRANDA, Karl, MEREDITH, Erik
Year of Publication 02.05.2018

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Patent

Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders

Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders

by LEE WENDY, MIRANDA KARL, WANG GAN, DUMAS JACQUES, SMITH ROGER
Year of Publication 12.11.2013

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Patent

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

by RAO, CHANG, JI, NAN, MA, FUPENG, ELLIOTT, JASON MATTHEW, LIU, DONGLEI, MEREDITH, ERIK, MIRANDA, KARL, POWERS, JAMES J, ARTMAN III, GERALD DAVID, MAINOLFI, NELLO
Year of Publication 31.10.2017

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Patent

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

by RAO, CHANG, JI, NAN, MA, FUPENG, LIU, DONGLEI, MEREDITH, ERIK, POWERS, JAMES, J, MIRANDA, KARL, ARTMAN III, GERALD, DAVID, MAINOLFI, NELLO, ELLIOTT, JASON, MATTHEW
Year of Publication 31.10.2017

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Patent

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

by Ma, Fupeng, Ji, Nan, Mainolfi, Nello, Artman III, Gerald David, Liu, Donglei, Powers, James J, Meredith, Erik, Miranda, Karl, Elliott, Jason Matthew, Rao, Chang
Year of Publication 06.10.2017

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Patent

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

by LIU Donglei, RAO Chang, POWERS James J, MIRANDA Karl, ELLIOTT Jason Matthew, MA Fupeng, MAINOLFI Nello, ARTMAN III Gerald David, JI Nan, MEREDITH Erik
Year of Publication 31.07.2017

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Patent

Pyridyloxyindolinhibitorer for VEGF-R2 og anvendelse deraf til behandling af sygdomme

Pyridyloxyindolinhibitorer for VEGF-R2 og anvendelse deraf til behandling af sygdomme

by ELLIOTT, Jason Matthew, POWERS, James J, JI, Nan, MA, Fupeng, RAO, Chang, ARTMAN III, Gerald David, MAINOLFI, Nello, LIU, Donglei, MIRANDA, Karl, MEREDITH, Erik
Year of Publication 31.07.2017

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Patent

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE

by ELLIOTT, Jason Matthew, POWERS, James J, JI, Nan, ARTMAN III, Gerald David, MA, Fupeng, RAO, Chang, MAINOLFI, Nello, LIU, Donglei, MIRANDA, Karl, MEREDITH, Erik
Year of Publication 10.07.2017

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Patent

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