Enzymatic Carboxylation of 2‑Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)
Payne, Karl A.P, Marshall, Stephen A, Fisher, Karl, Cliff, Matthew J, Cannas, Diego M, Yan, Cunyu, Heyes, Derren J, Parker, David A, Larrosa, Igor, Leys, David
Published in ACS catalysis (05.04.2019)
Published in ACS catalysis (05.04.2019)
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Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.K, Paradise, E.M, Ouellet, M, Fisher, K.J, Newman, K.L, Ndungu, J.M, Ho, K.A, Eachus, R.A, Ham, T.S, Kirby, J
Published in Nature (13.04.2006)
Published in Nature (13.04.2006)
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Inspection of plate weldments through an interposed layer of viscoelastic material using an elastic-electromagnetic scanning method
Fisher, Karl A, Mays, Owen, Haugen, Peter, Obenauf, David
Published in The Journal of the Acoustical Society of America (01.06.2019)
Published in The Journal of the Acoustical Society of America (01.06.2019)
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Structural basis of terephthalate recognition by solute binding protein TphC
Gautom, Trishnamoni, Dheeman, Dharmendra, Levy, Colin, Butterfield, Thomas, Alvarez Gonzalez, Guadalupe, Le Roy, Philip, Caiger, Lewis, Fisher, Karl, Johannissen, Linus, Dixon, Neil
Published in Nature communications (29.10.2021)
Published in Nature communications (29.10.2021)
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Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase
Bailey, Samuel S., Payne, Karl A. P., Saaret, Annica, Marshall, Stephen A., Gostimskaya, Irina, Kosov, Iaroslav, Fisher, Karl, Hay, Sam, Leys, David
Published in Nature chemistry (01.11.2019)
Published in Nature chemistry (01.11.2019)
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Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium
Belcher, James, McLean, Kirsty J., Matthews, Sarah, Woodward, Laura S., Fisher, Karl, Rigby, Stephen E.J., Nelson, David R., Potts, Donna, Baynham, Michael T., Parker, David A., Leys, David, Munro, Andrew W.
Published in The Journal of biological chemistry (07.03.2014)
Published in The Journal of biological chemistry (07.03.2014)
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UbiD domain dynamics underpins aromatic decarboxylation
Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, Titchiner, Gabriel R., Levy, Colin, Hay, Sam, Leys, David
Published in Nature communications (20.08.2021)
Published in Nature communications (20.08.2021)
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A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450BM3
Dietrich, Jeffrey A, Yoshikuni, Yasuo, Fisher, Karl J, Woolard, Frank X, Ockey, Denise, McPhee, Derek J, Renninger, Neil S, Chang, Michelle C. Y, Baker, David, Keasling, Jay D
Published in ACS chemical biology (17.04.2009)
Published in ACS chemical biology (17.04.2009)
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The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis
Bailey, Samuel S., Payne, Karl A.P, Fisher, Karl, Marshall, Stephen A., Cliff, Matthew J., Spiess, Reynard, Parker, David A., Rigby, Stephen E.J, Leys, David
Published in The Journal of biological chemistry (16.02.2018)
Published in The Journal of biological chemistry (16.02.2018)
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Arginine to Lysine Mutations Increase the Aggregation Stability of a Single-Chain Variable Fragment through Unfolded-State Interactions
Austerberry, James I, Thistlethwaite, Angela, Fisher, Karl, Golovanov, Alexander P, Pluen, Alain, Esfandiary, Reza, van der Walle, Christopher F, Warwicker, Jim, Derrick, Jeremy P, Curtis, Robin
Published in Biochemistry (Easton) (13.08.2019)
Published in Biochemistry (Easton) (13.08.2019)
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The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, White, Mark D., Ní Cheallaigh, Aisling, Balaikaite, Arune, Rigby, Stephen E. J., Leys, David
Published in Nature communications (29.05.2019)
Published in Nature communications (29.05.2019)
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Journal Article
Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis
Marshall, Stephen A., Fisher, Karl, Ní Cheallaigh, Aisling, White, Mark D., Payne, Karl A.P., Parker, D.A., Rigby, Stephen E.J., Leys, David
Published in The Journal of biological chemistry (17.03.2017)
Published in The Journal of biological chemistry (17.03.2017)
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Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions
Fisher, Karl J., Kinsey, Robert, Mohamath, Raodoh, Phan, Tony, Liang, Hong, Orr, Mark T., Lykins, William R., Guderian, Jeffrey A., Bakken, Julie, Argilla, David, Ramer-Denisoff, Gabi, Larson, Elise, Qi, Yizhi, Sivananthan, Sandra, Smolyar, Karina, Carter, Darrick, Paddon, Christopher J., Fox, Christopher B.
Published in npj vaccines (16.02.2023)
Published in npj vaccines (16.02.2023)
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Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code
Ortmayer, Mary, Fisher, Karl, Basran, Jaswir, Wolde-Michael, Emmanuel M, Heyes, Derren J, Levy, Colin, Lovelock, Sarah L, Anderson, J. L. Ross, Raven, Emma L, Hay, Sam, Rigby, Stephen E. J, Green, Anthony P
Published in ACS catalysis (21.02.2020)
Published in ACS catalysis (21.02.2020)
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Kilo-Scale GMP Synthesis of Renewable Semisynthetic Vaccine-Grade Squalene
Fisher, Karl J., Shirtcliff, Laura, Buchanan, Greg, Thompson, Andrew W., Woolard, Frank X., LaMunyon, Donald H., Marshall, Jonathan L., Baranouskas, Maya B., Voelker, Rodger B., Lusk, Jason S., Wells, Charles E., Mohamath, Raodoh, Kinsey, Robert, Lykins, William R., Ramer-Denisoff, Gabi, Fox, Christopher B., Paddon, Christopher J., McPhee, Derek
Published in Organic process research & development (15.12.2023)
Published in Organic process research & development (15.12.2023)
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