A small molecule mitigates hearing loss in a mouse model of Usher syndrome III
Alagramam, Kumar N, Gopal, Suhasini R, Geng, Ruishuang, Chen, Daniel H-C, Nemet, Ina, Lee, Richard, Tian, Guilian, Miyagi, Masaru, Malagu, Karine F, Lock, Christopher J, Esmieu, William R K, Owens, Andrew P, Lindsay, Nicola A, Ouwehand, Krista, Albertus, Faywell, Fischer, David F, Bürli, Roland W, MacLeod, Angus M, Harte, William E, Palczewski, Krzysztof, Imanishi, Yoshikazu
Published in Nature chemical biology (01.06.2016)
Published in Nature chemical biology (01.06.2016)
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Journal Article
Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection
Jacoby, Edgar, Schuffenhauer, Ansgar, Popov, Maxim, Azzaoui, Kamal, Havill, Benjamin, Schopfer, Ulrich, Engeloch, Caroline, Stanek, Jaroslav, Acklin, Pierre, Rigollier, Pascal, Stoll, Friederike, Koch, Guido, Meier, Peter, Orain, David, Giger, Rudolph, Hinrichs, Jürgen, Malagu, Karine, Zimmermann, Jürg, Roth, Hans-Joerg
Published in Current topics in medicinal chemistry (01.01.2005)
Published in Current topics in medicinal chemistry (01.01.2005)
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Journal Article
AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia
Published in Cancer research (Chicago, Ill.) (2010)
Published in Cancer research (Chicago, Ill.) (2010)
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Journal Article
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Journal Article
The discovery and optimisation of pyrido[2,3- d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase
Malagu, Karine, Duggan, Heather, Menear, Keith, Hummersone, Marc, Gomez, Sylvie, Bailey, Christine, Edwards, Peter, Drzewiecki, Jan, Leroux, Frédéric, Quesada, Mar Jimenez, Hermann, Gesine, Maine, Stephanie, Molyneaux, Carrie-Anne, Le Gall, Armelle, Pullen, James, Hickson, Ian, Smith, Lisa, Maguire, Sharon, Martin, Niall, Smith, Graeme, Pass, Martin
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Journal Article
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR
Menear, Keith A., Gomez, Sylvie, Malagu, Karine, Bailey, Christine, Blackburn, Kristel, Cockcroft, Xiao-Ling, Ewen, Sally, Fundo, Alexandra, Gall, Armelle Le, Hermann, Gesine, Sebastian, Luisa, Sunose, Mihiro, Presnot, Thomas, Torode, Eleanor, Hickson, Ian, Martin, Niall M.B., Smith, Graeme C.M., Pike, Kurt G.
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Journal Article
Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer
Guichard, Sylvie M., Howard, Zoe, Heathcote, Dan, Roth, Mark, Hughes, Gareth, Curwen, Jon, Yates, James, Logie, Armelle, Holt, Sarah, Chresta, Christine M., Davies, Barry R., Malagu, Karine, Hummersone, Marc, Pass, Sarah L., Green, Stephen, Pass, Martin
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Synthesis of C-19-functionalized 1 alpha-hydroxyvitamin D-2 analogues via ring-closing metathesis
Ahmed, M, Atkinson, CE, Barrett, AGM, Malagu, K, Procopiou, PA
Published in Organic letters (06.03.2003)
Published in Organic letters (06.03.2003)
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Journal Article
Directed ring-closing metathesis of trienes by silyl substitution
Schultz-Fademrecht, Carsten, Deshmukh, Prashant H., Malagu, Karine, Procopiou, Panayiotis A., Barrett, Anthony G.M.
Published in Tetrahedron (23.08.2004)
Published in Tetrahedron (23.08.2004)
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Journal Article
N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
CLISSOLD, Cole, MALAGU, Karine, HAUGHAN, Alan, DOMINGUEZ, Celia, SPENCER, Jonathan, STOTT, Andrew, VATER, Huw, PLOTNIKOV, Nikolay V, COSGROVE, Brett, LIU, Longbin, ESMIEU, William, CHAMBERS, Mark
Year of Publication 25.09.2024
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Year of Publication 25.09.2024
Patent
Htt modulators for treating huntington's disease
Longbin LIU, Alan HAUGHAN, Andrew STOTT, Cole CLISSOLD, Huw VATER, Celia DOMINGUEZ, Karine MALAGU, Nikolay V. PLOTNIKOV, Jonathan SPENCER, William ESMIEU, Brett COSGROVE, Mark CHAMBERS
Year of Publication 01.07.2024
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Year of Publication 01.07.2024
Patent
N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
CLISSOLD, Cole, MALAGU, Karine, HAUGHAN, Alan, DOMINGUEZ, Celia, SPENCER, Jonathan, STOTT, Andrew, VATER, Huw, PLOTNIKOV, Nikolay V, COSGROVE, Brett, LIU, Longbin, ESMIEU, William, CHAMBERS, Mark
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Non-fused thiophene derivatives and their uses
Knight, Jamie David, Lanaro, Roberta, Machin, Peter, De Chassey, Benoît, Malagu, Karine Fabienne, Chambers, Mark, Meldrum, Eric, Winship, Paul Colin Michael
Year of Publication 12.12.2023
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Year of Publication 12.12.2023
Patent