Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
Graves, Paul R, Aponte-Collazo, Lucas J, Fennell, Emily M. J, Graves, Adam C, Hale, Andrew E, Dicheva, Nedyalka, Herring, Laura E, Gilbert, Thomas S. K, East, Michael P, McDonald, Ian M, Lockett, Matthew R, Ashamalla, Hani, Moorman, Nathaniel J, Karanewsky, Donald S, Iwanowicz, Edwin J, Holmuhamedov, Ekhson, Graves, Lee M
Published in ACS chemical biology (17.05.2019)
Published in ACS chemical biology (17.05.2019)
Get full text
Journal Article
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
Mabanglo, Mark F., Wong, Keith S., Barghash, Marim M., Leung, Elisa, Chuang, Stephanie H.W., Ardalan, Afshan, Majaesic, Emily M., Wong, Cassandra J., Zhang, Shen, Lang, Henk, Karanewsky, Donald S., Iwanowicz, Andrew A., Graves, Lee M., Iwanowicz, Edwin J., Gingras, Anne-Claude, Houry, Walid A.
Published in Structure (London) (02.02.2023)
Published in Structure (London) (02.02.2023)
Get full text
Journal Article
The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells in vitro
Fatima, Narjis, Shen, Yandong, Crassini, Kyle, Burling, Olivia, Thurgood, Lauren, Iwanowicz, Edwin J, Lang, Henk, Karanewsky, Donald S, Christopherson, Richard I, Mulligan, Stephen P, Best, O Giles
Published in Leukemia & lymphoma (01.05.2024)
Published in Leukemia & lymphoma (01.05.2024)
Get more information
Journal Article
Positive allosteric modulators of the human sweet taste receptor enhance sweet taste
Servant, Guy, Tachdjian, Catherine, Tang, Xiao-Qing, Werner, Sara, Zhang, Feng, Li, Xiaodong, Kamdar, Poonit, Petrovic, Goran, Ditschun, Tanya, Java, Antoniette, Brust, Paul, Brune, Nicole, DuBois, Grant E, Zoller, Mark, Karanewsky, Donald S
Published in Proceedings of the National Academy of Sciences - PNAS (09.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (09.03.2010)
Get full text
Journal Article
Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists
Fotsing, Joseph R, Darmohusodo, Vincent, Patron, Andrew P, Ching, Brett W, Brady, Thomas, Arellano, Melissa, Chen, Qing, Davis, Timothy J, Liu, Hanghui, Servant, Guy, Zhang, Lan, Williams, Mark, Saganich, Michael, Ditschun, Tanya, Tachdjian, Catherine, Karanewsky, Donald S
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
Get full text
Journal Article
Correction to “Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues”
Graves, Paul R., Aponte-Collazo, Lucas J., Fennell, Emily M. J., Graves, Adam C., Hale, Andrew E., Dicheva, Nedyalka, Herring, Laura E., Gilbert, Thomas S. K., East, Michael P., McDonald, Ian M., Lockett, Matthew R., Ashamalla, Hani, Moorman, Nathaniel J., Karanewsky, Donald S., Iwanowicz, Edwin J., Holmuhamedov, Ekhson, Graves, Lee M.
Published in ACS chemical biology (19.08.2022)
Published in ACS chemical biology (19.08.2022)
Get full text
Journal Article
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
Fennell, Emily M. J., Aponte‐Collazo, Lucas J., Wynn, Joshua D., Drizyte‐Miller, Kristina, Leung, Elisa, Greer, Yoshimi Endo, Graves, Paul R., Iwanowicz, Andrew A., Ashamalla, Hani, Holmuhamedov, Ekhson, Lang, Henk, Karanewsky, Donald S., Der, Channing J., Houry, Walid A., Lipkowitz, Stanley, Iwanowicz, Edwin J., Graves, Lee M.
Published in Pharmacology research & perspectives (01.08.2022)
Published in Pharmacology research & perspectives (01.08.2022)
Get full text
Journal Article
Toxicological evaluation of two flavors with modifying properties: 3-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)piperidin-1-yl)-3-methylbutan-1-one
Arthur, Amy J, Karanewsky, Donald S, Luksic, Mike, Goodfellow, Geoff, Daniels, Jon
Published in Food and chemical toxicology (01.02.2015)
Published in Food and chemical toxicology (01.02.2015)
Get full text
Journal Article
Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2
Jiang, Tao, Kuhen, Kelli L., Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Tuntland, Tove, Zhang, Kanyin, Karanewsky, Donald, He, Yun
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Get full text
Journal Article
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models
Albaugh, Pam, Fan, Yi, Mi, Yuan, Sun, Fangxian, Adrian, Francisco, Li, Nanxin, Jia, Yong, Sarkisova, Yelena, Kreusch, Andreas, Hood, Tami, Lu, Min, Liu, Guoxun, Huang, Shenlin, Liu, Zuosheng, Loren, Jon, Tuntland, Tove, Karanewsky, Donald S, Seidel, H. Martin, Molteni, Valentina
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
Get full text
Journal Article
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Marsilje, Thomas H, Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C, Li, Allen G, Joseph, Sean B, Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S, Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C, Bursulaya, Badry, Karanewsky, Donald S, Seidel, H. Martin, Harris, Jennifer L, Michellys, Pierre-Yves
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
Get full text
Journal Article
The ClpP activator ONC‐212 (TR‐31) inhibits BCL2 and B‐cell receptor signaling in CLL
Fatima, Narjis, Shen, Yandong, Crassini, Kyle, Iwanowicz, Edwin J., Lang, Henk, Karanewsky, Donald S., Christopherson, Richard I., Mulligan, Stephen P., Best, Oliver G.
Published in EJHaem (01.02.2021)
Published in EJHaem (01.02.2021)
Get full text
Journal Article
Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists
Epple, Robert, Cow, Christopher, Xie, Yongping, Azimioara, Mihai, Russo, Ross, Wang, Xing, Wityak, John, Karanewsky, Donald S, Tuntland, Tove, Nguyêñ-Trân, Vân T. B, Cuc Ngo, Cara, Huang, David, Saez, Enrique, Spalding, Tracy, Gerken, Andrea, Iskandar, Maya, Seidel, H. Martin, Tian, Shin-Shay
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
Get full text
Journal Article
Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione
Karanewsky, Donald S., Arthur, Amy J., Liu, Hanghui, Chi, Bert, Ida, Lily, Markison, Stacy
Published in Toxicology reports (01.01.2016)
Published in Toxicology reports (01.01.2016)
Get full text
Journal Article
Toxicological evaluation of the flavour ingredient N -(1-((4-amino-2,2-dioxido-1 H -benzo[ c ][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218)
Karanewsky, Donald S, Servant, Guy, Liu, Hanghui, Chi, Bert, Ida, Lily, Saganich, Michael, Werner, Sara, Fotsing, Joseph R, Patron, Andrew, Tachdjian, Catherine, Arthur, Amy
Published in Toxicology reports (01.01.2017)
Published in Toxicology reports (01.01.2017)
Get full text
Journal Article
Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1 H -pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1 H -pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione
Karanewsky, Donald S, Arthur, Amy J, Liu, Hanghui, Chi, Bert, Ida, Lily, Markison, Stacy
Published in Toxicology reports (2016)
Published in Toxicology reports (2016)
Get full text
Journal Article
Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines
Roach, Steven L., Higuchi, Robert I., Adams, Mark E., Liu, Yan, Karanewsky, Donald S., Marschke, Keith B., Mais, Dale E., Miner, Jeffrey N., Zhi, Lin
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
Get full text
Journal Article