Acyl dipeptides as reversible caspase inhibitors. Part 1: Initial lead optimization
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Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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Structure–activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads
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Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors
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Published in The Journal of biological chemistry (12.07.1996)
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Design and synthesis of novel RXR-selective modulators with improved pharmacological profile
Michellys, Pierre-Yves, Boehm, Marcus F, Chen, Jyun-Hung, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Reifel-Miller, Anne, Ogilvie, Katheen M, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Yumibe, Nathan, Ardecky, Robert J
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke
Linton, Steven D., Aja, Teresa, Allegrini, Peter R., Deckwerth, Thomas L., Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G., Kallen, Joerg, Karanewsky, Donald S., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O., Schmitz, Albert, Smidt, Robert, Ternansky, Robert J., Tomaselli, Kevin J., Ullman, Brett R., Wiessner, Christoph, Wu, Joe C.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
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Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone
Mittl, Peer R.E., Di Marco, Stefania, Krebs, Joseph F., Bai, Xu, Karanewsky, Donald S., Priestle, John P., Tomaselli, Kevin J., Grütter, Markus G.
Published in The Journal of biological chemistry (07.03.1997)
Published in The Journal of biological chemistry (07.03.1997)
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Structure-activity relationships within a series of caspase inhibitors: Effect of leaving group modifications
ULLMAN, Brett R, AJA, Teresa, ROGGO, Silvio P, SAYERS, Robert O, SCHMITZ, Albert, TERNANSKY, Robert J, TOMASELLI, Kevin J, WU, Joe C, DECKWERTH, Thomas L, DIAZ, Jose-Luis, HERRMANN, Julia, KALISH, Vincent J, KARANEWSKY, Donald S, MEDUNA, Steven P, NALLEY, Kip, ROBINSON, Edward D
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
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Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Acyl dipeptides as reversible caspase inhibitors. Part 2: Further optimization
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Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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Vasopeptidase Inhibitors: Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides
Robl, Jeffrey A, Sulsky, Richard, Sieber-McMaster, Ellen, Ryono, Denis E, Cimarusti, Maria P, Simpkins, Ligaya M, Karanewsky, Donald S, Chao, Sam, Asaad, Magdi M, Seymour, Andrea A, Fox, Maxine, Smith, Patricia L, Trippodo, Nick C
Published in Journal of medicinal chemistry (28.01.1999)
Published in Journal of medicinal chemistry (28.01.1999)
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Potent ClpP agonists with anticancer properties bind the protease with improved structural complementarity and alter the mitochondrial N-terminome
Mabanglo, Mark F., Wong, Keith S., Barghash, Marim M., Leung, Elisa, Chuang, Stephanie H. W., Ardalan, Afshan, Majaesic, Emily M., Wong, Cassandra J., Zhang, Shen, Lang, Henk, Karanewsky, Donald S., Iwanowicz, Andrew A., Graves, Lee M., Iwanowicz, Edwin J., Gingras, Anne-Claude, Houry, Walid A.
Published in Structure (London) (15.12.2022)
Published in Structure (London) (15.12.2022)
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Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines
Krapcho, John, Turk, Chester, Cushman, David W, Powell, James R, DeForrest, Jack M, Spitzmiller, Ervin R, Karanewsky, Donald S, Duggan, Mark, Rovnyak, George
Published in Journal of medicinal chemistry (01.06.1988)
Published in Journal of medicinal chemistry (01.06.1988)
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Year of Publication 13.03.2020
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Year of Publication 13.03.2020
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Toxicological evaluation of two flavors with modifying properties: 3-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2 - dimethyl-N-propylpropanamide and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl) o xy)methyl)piperidin-1-yl)-3-methylbutan-1-one
Arthur, Amy J, Karanewsky, Donald S, Luksic, Mike, Goodfellow, Geoff, Daniels, Jon
Published in Food and chemical toxicology (01.02.2015)
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SWEET FLAVOR MODIFIER
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Year of Publication 06.01.2020
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Year of Publication 06.01.2020
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Practical synthesis of an enantiomerically pure synthon for the preparation of mevinic acid analogs
Karanewsky, Donald S, Malley, Mary F, Gougoutas, Jack Z
Published in Journal of organic chemistry (01.05.1991)
Published in Journal of organic chemistry (01.05.1991)
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(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline, a novel orally active inhibitor of ACE
Karanewsky, Donald S, Badia, Michael C, Cushman, David W, DeForrest, Jack M, Dejneka, Tamara, Loots, Melanie J, Perri, Maria G, Petrillo, Edward W, Powell, James R
Published in Journal of medicinal chemistry (01.01.1988)
Published in Journal of medicinal chemistry (01.01.1988)
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A highly selective protocol for the deprotection of BOC-protected amides and carbamates
Stafford, Jeffrey A., Brackeen, Marcus F., Karanewsky, Donald S., Valvano, Nicole L.
Published in Tetrahedron letters (03.12.1993)
Published in Tetrahedron letters (03.12.1993)
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Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors
Ellis, David, Kuhen, Kelli L., Anaclerio, Beth, Wu, Baogen, Wolff, Karen, Yin, Hong, Bursulaya, Badry, Caldwell, Jeremy, Karanewsky, Donald, He, Yun
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety
Robl, Jeffrey A, Duncan, Laurelee A, Pluscec, Jelka, Karanewsky, Donald S, Gordon, Eric M, Ciosek, Carl P, Rich, Lois C, Dehmel, Viviane C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
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