HCF-1 is cleaved in the active site of O-GlcNAc transferase
Lazarus, Michael B, Jiang, Jiaoyang, Kapuria, Vaibhav, Bhuiyan, Tanja, Janetzko, John, Zandberg, Wesley F, Vocadlo, David J, Herr, Winship, Walker, Suzanne
Published in Science (American Association for the Advancement of Science) (06.12.2013)
Published in Science (American Association for the Advancement of Science) (06.12.2013)
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Journal Article
Distinct OGT-Binding Sites Promote HCF-1 Cleavage
Bhuiyan, Tanja, Waridel, Patrice, Kapuria, Vaibhav, Zoete, Vincent, Herr, Winship
Published in PloS one (25.08.2015)
Published in PloS one (25.08.2015)
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Journal Article
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis
Sun, Hanshi, Kapuria, Vaibhav, Peterson, Luke F., Fang, Dexing, Bornmann, William G., Bartholomeusz, Geoffrey, Talpaz, Moshe, Donato, Nicholas J.
Published in Blood (17.03.2011)
Published in Blood (17.03.2011)
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Journal Article
Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats
Rafie, Karim, Raimi, Olawale, Ferenbach, Andrew T., Borodkin, Vladimir S., Kapuria, Vaibhav, van Aalten, Daan M. F.
Published in Open biology (01.06.2017)
Published in Open biology (01.06.2017)
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Journal Article
Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells
Bartholomeusz, Geoffrey A., Talpaz, Moshe, Kapuria, Vaibhav, Kong, Ling Yuan, Wang, Shimei, Estrov, Zeev, Priebe, Waldemar, Wu, Ji, Donato, Nicholas J.
Published in Blood (15.04.2007)
Published in Blood (15.04.2007)
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A Small Molecule Deubiquitinase Inhibitor Increases Localization of Inducible Nitric Oxide Synthase to the Macrophage Phagosome and Enhances Bacterial Killing
BURKHOLDER, Kristin M, PERRY, Jeffrey W, WOBUS, Christiane E, DONATO, Nicholas J, SHOWALTER, Hollis D, KAPURIA, Vaibhav, O'RIORDAN, Mary X. D
Published in Infection and Immunity (01.12.2011)
Published in Infection and Immunity (01.12.2011)
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Journal Article
The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities
Kapuria, Vaibhav, Röhrig, Ute F., Waridel, Patrice, Lammers, Fabienne, Borodkin, Vladimir S., van Aalten, Daan M.F., Zoete, Vincent, Herr, Winship
Published in The Journal of biological chemistry (16.11.2018)
Published in The Journal of biological chemistry (16.11.2018)
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Journal Article
A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination
Kapuria, Vaibhav, Levitzki, Alexander, Bornmann, William G., Maxwell, David, Priebe, Waldemar, Sorenson, Roderick J., Showalter, Hollis D., Talpaz, Moshe, Donato, Nicholas J.
Published in Cellular signalling (01.12.2011)
Published in Cellular signalling (01.12.2011)
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Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
Kapuria, Vaibhav, Peterson, Luke F., Showalter, H.D. Hollis, Kirchhoff, Paul D., Talpaz, Moshe, Donato, Nicholas J.
Published in Biochemical pharmacology (15.08.2011)
Published in Biochemical pharmacology (15.08.2011)
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Journal Article
HCF-1 Is Cleaved in the Active Site of 0-GlcNAc Transferase
Lazarus, Michael B., Jiang, Jiaoyang, Kapuria, Vaibhav, Bhuiyan, Tanja, Janetzko, John, Zandberg, Wesley F., Vocadlo, David J., Herr, Winship, Walker, Suzanne
Published in Science (American Association for the Advancement of Science) (06.12.2013)
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Published in Science (American Association for the Advancement of Science) (06.12.2013)
Journal Article
Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)
Peng, Zhenghong, Maxwell, David S., Sun, Duoli, Bhanu Prasad, Basvoju A., Schuber, Paul T., Pal, Ashutosh, Ying, Yunming, Han, Dongmei, Gao, Liwei, Wang, Shimei, Levitzki, Alexander, Kapuria, Vaibhav, Talpaz, Moshe, Young, Matthew, Showalter, Hollis D., Donato, Nicholas J., Bornmann, William G.
Published in Bioorganic & medicinal chemistry (15.02.2014)
Published in Bioorganic & medicinal chemistry (15.02.2014)
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Journal Article
The conserved threonine-rich region of the HCF-1 PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities
Kapuria, Vaibhav, Röhrig, Ute F, Waridel, Patrice, Lammers, Fabienne, Borodkin, Vladimir S, van Aalten, Daan M F, Zoete, Vincent, Herr, Winship
Published in The Journal of biological chemistry (16.11.2018)
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Published in The Journal of biological chemistry (16.11.2018)
Journal Article
Inhibition of Usp9x Deubiquitinase Activity by WP1130 Reduces Mcl-1 Levels and Induces Apoptosis In Cells From Patients with Plasma Cell Dyscrasia and Drug-Refractory Multiple Myeloma
Sun, Hanshi, Kapuria, Vaibhav, Peterson, Luke F., Giannola, Diane, Malathi, Kandarpa, Talpaz, Moshe, Jakubowiak, Andrzej J, Donato, Nicholas
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Journal Article
Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130
Kapuria, Vaibhav, Peterson, Luke F, Bornmann, William, Talpaz, Moshe, Donato, Nicholas J
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Journal Article
WP1130 Inhibits Signaling through BCR-ABL Ubiquitination and Cytoplasmic to Aggresome Trafficking to Induce Apoptosis of CML Cells
Donato, Nicholas J, Sun, Hanshi, Kapuria, Vaibhav, Peterson, Luke F, Bartholomeusz, Geoffrey, Bornmann, William G., Talpaz, Moshe
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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