Lsd1 prevents age-programed loss of beige adipocytes
Duteil, Delphine, Tosic, Milica, Willmann, Dominica, Georgiadi, Anastasia, Kanouni, Toufike, Schüle, Roland
Published in Proceedings of the National Academy of Sciences - PNAS (16.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (16.05.2017)
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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)
Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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KDM4 Inhibition Targets Breast Cancer Stem-like Cells
Metzger, Eric, Stepputtis, Stella S, Strietz, Juliane, Preca, Bogdan-Tiberius, Urban, Sylvia, Willmann, Dominica, Allen, Anita, Zenk, Fides, Iovino, Nicola, Bronsert, Peter, Proske, Amelie, Follo, Marie, Boerries, Melanie, Stickeler, Elmar, Xu, Jiangchun, Wallace, Michael B, Stafford, Jeffrey A, Kanouni, Toufike, Maurer, Jochen, Schüle, Roland
Published in Cancer research (Chicago, Ill.) (01.11.2017)
Published in Cancer research (Chicago, Ill.) (01.11.2017)
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Journal Article
Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue
Duteil, Delphine, Tosic, Milica, Lausecker, Franziska, Nenseth, Hatice Z., Müller, Judith M., Urban, Sylvia, Willmann, Dominica, Petroll, Kerstin, Messaddeq, Nadia, Arrigoni, Laura, Manke, Thomas, Kornfeld, Jan-Wilhelm, Brüning, Jens C., Zagoriy, Vyacheslav, Meret, Michael, Dengjel, Jörn, Kanouni, Toufike, Schüle, Roland
Published in Cell reports (Cambridge) (18.10.2016)
Published in Cell reports (Cambridge) (18.10.2016)
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Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer
Dong, Qing, Dougan, Douglas R., Gong, Xianchang, Halkowycz, Petro, Jin, Bohan, Kanouni, Toufike, O’Connell, Shawn M., Scorah, Nicholas, Shi, Lihong, Wallace, Michael B., Zhou, Feng
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models
Franovic, Aleksandra, Miller, Nichol, Severson, Paul, Kanouni, Toufike, Timple, Noelito, Jiang, Ping, Murphy, Eric, Martin, Eric
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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(S)-N-(3-(2-(((R)-1-하이드록시프로판-2-일)아미노)-6-모르폴리노피리딘-4-일)-4-메틸페닐)-3-피롤리딘-1-카르복스아미드 및 이의 염의 고체 상태 형태
PHIMISTER ANDREW, KALDOR STEPHEN W, KANOUNI TOUFIKE, REDDY JAYACHANDRA P
Year of Publication 02.01.2024
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Year of Publication 02.01.2024
Patent
Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase
Smith, Christopher R., Dougan, Douglas R., Komandla, Mallareddy, Kanouni, Toufike, Knight, Beverly, Lawson, J. David, Sabat, Mark, Taylor, Ewan R., Vu, Phong, Wyrick, Corey
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition
Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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MET 키나제의 억제제
OUYANG XIAOHU S, COX JASON M, KANIA ROBERT, KANOUNI TOUFIKE, TYHONAS JOHN S
Year of Publication 09.08.2024
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Year of Publication 09.08.2024
Patent
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
Castex, Josefina, Willmann, Dominica, Kanouni, Toufike, Arrigoni, Laura, Li, Yan, Friedrich, Marcel, Schleicher, Michael, Wöhrle, Simon, Pearson, Mark, Kraut, Norbert, Méret, Michaël, Manke, Thomas, Metzger, Eric, Schüle, Roland, Günther, Thomas
Published in Cell death & disease (23.02.2017)
Published in Cell death & disease (23.02.2017)
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FGFR 저해제의 고체 상태 형태
PHIMISTER ANDREW, KALDOR STEPHEN W, TYHONAS JOHN, COX JASON M, CHOPADE SHUBHAM, KANIA ROBERT, KANOUNI TOUFIKE, REDDY JAYACHANDRA P, PANDEY PREETANSHU
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent
CDK12/13 억제제에 의한 암 치료
ARNOLD LEE D, MARTIN ERIC, MURPHY ERIC A, GARDINER ELISABETH, TYHONAS JOHN, TIMPLE NOELITO, KANOUNI TOUFIKE
Year of Publication 05.09.2022
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Year of Publication 05.09.2022
Patent
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors
Nie, Zhe, Shi, Lihong, Lai, Chon, Severin, Christophe, Xu, Jiangchun, Del Rosario, Joselyn R., Stansfield, Ryan K., Cho, Robert W., Kanouni, Toufike, Veal, James M., Stafford, Jeffrey A., Chen, Young K.
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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섬유아세포 성장 인자 수용체 키나아제의 억제제
ARNOLD LEE D, MURPHY ERIC A, KALDOR STEPHEN W, TYHONAS JOHN, COX JASON M, KANIA ROBERT, KANOUNI TOUFIKE
Year of Publication 10.03.2023
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Year of Publication 10.03.2023
Patent
Abstract 2674: Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in preclinical models of human RAF/RAS mutant melanoma
Miller, Nichol L. G., Wang, Tim S., Severson, Paul, Jiang, Ping, Perez, Michelle, Timple, Noel, Kanouni, Toufike, Franovic, Aleksandra, Martin, Eric S., Murphy, Eric
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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