An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
Get full text
Journal Article
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Sun, Yuting, Meyers, Brooke A, Czako, Barbara, Leonard, Paul, Mseeh, Faika, Harris, Angela L, Wu, Qi, Johnson, Sarah, Parker, Connor A, Cross, Jason B, Di Francesco, Maria Emilia, Bivona, Benjamin J, Bristow, Christopher A, Burke, Jason P, Carrillo, Caroline C, Carroll, Christopher L, Chang, Qing, Feng, Ningping, Gao, Guang, Gera, Sonal, Giuliani, Virginia, Huang, Justin K, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Liu, Chiu-Yi, Lopez, Anastasia M, Ma, Xiaoyan, Mandal, Pijus K, McAfoos, Timothy, Miller, Meredith A, Mullinax, Robert A, Peoples, Michael, Ramamoorthy, Vandhana, Seth, Sahil, Spencer, Nakia D, Suzuki, Erika, Williams, Christopher C, Yu, Simon S, Zuniga, Andy M, Draetta, Giulio F, Marszalek, Joseph R, Heffernan, Timothy P, Kohl, Nancy E, Jones, Philip
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Get full text
Journal Article
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers
Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C, Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J, Georgiou, Dimitra K, Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G, Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M, Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R, DePinho, Ronald A, Muller, Florian L
Published in Nature metabolism (01.12.2020)
Published in Nature metabolism (01.12.2020)
Get more information
Journal Article
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
Get full text
Journal Article
Non-Pulse-Leakage 100-kHz Level, High Beam Quality Industrial Grade Nd:YVO4 Picosecond Amplifier
Bai, Zhenao, Bai, Zhenxu, Kang, Zhijun, Lian, Fuqiang, Lin, Weiran, Fan, Zhongwei
Published in Applied sciences (01.06.2017)
Published in Applied sciences (01.06.2017)
Get full text
Journal Article
Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease
Helal, Christopher J., Kang, Zhijun, Lucas, John C., Gant, Thomas, Ahlijanian, Michael K., Schachter, Joel B., Richter, Karl E.G., Cook, James M., Menniti, Frank S., Kelly, Kristin, Mente, Scot, Pandit, Jay, Hosea, Natalie
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Get full text
Journal Article
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease
Helal, Christopher J., Sanner, Mark A., Cooper, Christopher B., Gant, Thomas, Adam, Mavis, Lucas, John C., Kang, Zhijun, Kupchinsky, Stanley, Ahlijanian, Michael K., Tate, Bonnie, Menniti, Frank S., Kelly, Kristin, Peterson, Marcia
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Get full text
Journal Article
Generating multicluster conservative chaotic flows from a generalized Sprott-A system
Cang, Shijian, Li, Yue, Kang, Zhijun, Wang, Zenghui
Published in Chaos, solitons and fractals (01.04.2020)
Published in Chaos, solitons and fractals (01.04.2020)
Get full text
Journal Article
A generic method for constructing n-fold covers of 3D conservative chaotic systems
Cang, Shijian, Li, Yue, Kang, Zhijun, Wang, Zenghui
Published in Chaos (Woodbury, N.Y.) (01.03.2020)
Published in Chaos (Woodbury, N.Y.) (01.03.2020)
Get more information
Journal Article
A new conservative system with isolated invariant tori and six-cluster chaotic flows
Li, Yue, Cang, Shijian, Kang, Zhijun, Wang, Zenghui
Published in The European physical journal. ST, Special topics (01.03.2020)
Published in The European physical journal. ST, Special topics (01.03.2020)
Get full text
Journal Article