Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs
Liu, Zhaoqiang, Tian, Ye, Liu, Jinghan, Huang, Boshi, Kang, Dongwei, De Clercq, Erik, Daelemans, Dirk, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in European journal of medicinal chemistry (10.11.2017)
Published in European journal of medicinal chemistry (10.11.2017)
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Design and optimization of piperidine-substituted thiophene3,2-dpyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
Sun, Yanying, Zhou, Zhenzhen, Shi, Zhongling, Zhao, Fabao, Xie, Minghui, Zhuo, Zongji, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Published in Acta pharmaceutica Sinica. B (01.07.2024)
Published in Acta pharmaceutica Sinica. B (01.07.2024)
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Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7
Sun, Songkai, Huang, Boshi, Li, Zhuo, Wang, Zhao, Sun, Lin, Gao, Ping, Kang, Dongwei, Chen, Chin-Ho, Lee, Kuo-Hsiung, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties
Jiang, Xiangyi, Huang, Boshi, Olotu, Fisayo A., Li, Jing, Kang, Dongwei, Wang, Zhao, De Clercq, Erik, Soliman, Mahmoud E.S., Pannecouque, Christophe, Liu, Xinyong, Zhan, Peng
Published in European journal of medicinal chemistry (05.03.2021)
Published in European journal of medicinal chemistry (05.03.2021)
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Journal Article
Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators
Zhang, Xujie, Sun, Lin, Xu, Shujing, Huang, Tianguang, Zhao, Fabao, Ding, Dang, Liu, Chuanfeng, Jiang, Xiangyi, Tao, Yucen, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Cocklin, Simon, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Published in MedChemComm (20.07.2023)
Published in MedChemComm (20.07.2023)
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Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket
Meng, Qing, Chen, Xuwang, Kang, Dongwei, Huang, Boshi, Li, Wenxin, Zhan, Peng, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Liu, Xinyong
Published in European journal of medicinal chemistry (10.06.2016)
Published in European journal of medicinal chemistry (10.06.2016)
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Journal Article
Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities
Huang, Boshi, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Published in Expert opinion on drug discovery (02.12.2015)
Published in Expert opinion on drug discovery (02.12.2015)
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Journal Article
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
Kang, Dongwei, Ruiz, F. Xavier, Feng, Da, Pilch, Alyssa, Zhao, Tong, Wei, Fenju, Wang, Zhao, Sun, Yanying, Fang, Zengjun, De Clercq, Erik, Pannecouque, Christophe, Arnold, Eddy, Zhan, Peng, Liu, Xinyong
Published in Journal of medicinal chemistry (24.01.2020)
Published in Journal of medicinal chemistry (24.01.2020)
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Journal Article
Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach
Lu, Xueyi, Li, Xiao, Yang, Jiapei, Huang, Boshi, Kang, Dongwei, Zhao, Fabao, Zhou, Zhongxia, De Clercq, Erik, Daelemans, Dirk, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Bioorganic & medicinal chemistry (15.09.2016)
Published in Bioorganic & medicinal chemistry (15.09.2016)
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Journal Article
Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors
Wang, Zhao, Kang, Dongwei, Chen, Meng, Wu, Gaochan, Feng, Da, Zhao, Tong, Zhou, Zhongxia, Huo, Zhipeng, Jing, Lanlan, Zuo, Xiaofang, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Chemical biology & drug design (01.12.2018)
Published in Chemical biology & drug design (01.12.2018)
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Journal Article
Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2)
Huang, Boshi, Zhou, Zhongxia, Kang, Dongwei, Li, Wanzhuo, Chen, Zihui, Zhan, Peng, Liu, Xinyong
Published in Expert opinion on therapeutic patents (02.01.2017)
Published in Expert opinion on therapeutic patents (02.01.2017)
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Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors
Fang, Zengjun, Kang, Dongwei, Zhang, Lingzi, Huang, Boshi, Liu, Huiqing, Pannecouque, Christophe, De Clercq, Erik, Zhan, Peng, Liu, Xinyong
Published in Chemical biology & drug design (01.10.2015)
Published in Chemical biology & drug design (01.10.2015)
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Journal Article
Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP
Zhang, Tao, Zhou, Zhongxia, Zalloum, Waleed A., Wang, Zhao, Fu, Zhipeng, Cherukupalli, Srinivasulu, Feng, Da, Sun, Yanying, Gao, Shenghua, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Published in Bioorganic chemistry (01.11.2021)
Published in Bioorganic chemistry (01.11.2021)
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Journal Article
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV‑1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site
Huo, Zhipeng, Zhang, Heng, Kang, Dongwei, Zhou, Zhongxia, Wu, Gaochan, Desta, Samuel, Zuo, Xiaofang, Wang, Zhao, Jing, Lanlan, Ding, Xiao, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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Journal Article
Discovery of Thiophene[3,2‑d]pyrimidine Derivatives as Potent HIV‑1 NNRTIs Targeting the Tolerant Region I of NNIBP
Kang, Dongwei, Ding, Xiao, Wu, Gaochan, Huo, Zhipeng, Zhou, Zhongxia, Zhao, Tong, Feng, Da, Wang, Zhao, Tian, Ye, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in ACS medicinal chemistry letters (09.11.2017)
Published in ACS medicinal chemistry letters (09.11.2017)
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Journal Article
Discovery of potent HIV‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I
Kang, Dongwei, Wang, Zhao, Chen, Meng, Feng, Da, Wu, Gaochan, Zhou, Zhongxia, Jing, Lanlan, Zuo, Xiaofang, Jiang, Xiangyi, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Chemical biology & drug design (01.04.2019)
Published in Chemical biology & drug design (01.04.2019)
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Journal Article
Can conservation of single surrogate species protect co-occurring species?
Kang, Dongwei, Yang, Hongwei, Li, Junqing, Chen, Youping
Published in Environmental science and pollution research international (01.09.2013)
Published in Environmental science and pollution research international (01.09.2013)
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Journal Article
From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface
Shujing Xu, Lin Sun, Waleed A.Zalloum, Xujie Zhang, Tianguang Huang, Dang Ding, Yucen Tao, Fabao Zhao, Shenghua Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Simon Cocklin, Xinyong Liu, Peng Zhan
Published in 中国化学快报（英文版） (2023)
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Published in 中国化学快报（英文版） (2023)
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