Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors’ Binding Pocket
Zhao, Fabao, Zhang, Heng, Xie, Minghui, Meng, Bairu, Liu, Na, Dun, Caiyun, Qin, Yanyang, Gao, Shenghua, De Clercq, Erik, Pannecouque, Christophe, Tang, Ya-Jie, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in Journal of medicinal chemistry (09.02.2023)
Published in Journal of medicinal chemistry (09.02.2023)
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Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features
Gao, Shenghua, Cheng, Yusen, Song, Shu, Song, Letian, Zhao, Fabao, Xu, Shujing, Kang, Dongwei, Sun, Lin, Gao, Ping, De Clercq, Erik, Pannecouque, Christophe, Liu, Xinyong, Zhan, Peng
Published in European journal of medicinal chemistry (05.08.2022)
Published in European journal of medicinal chemistry (05.08.2022)
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Structure‐based design of diarylpyrimidines and triarylpyrimidines as potent HIV‐1 NNRTIs with improved metabolic stability and drug resistance profiles
Xie, Minghui, Wang, Zhao, Zhao, Fabao, Li, Ye, Zhuo, Zongji, Li, Xin, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in Journal of medical virology (01.03.2024)
Published in Journal of medical virology (01.03.2024)
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Design and synthesis of Fsp3‐enriched spirocyclic‐substituted diarylpyrimidine derivatives as novel HIV‐1 NNRTIs
Sang, Zihao, Zhang, Tao, Wang, Zhao, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Published in Chemical biology & drug design (01.03.2024)
Published in Chemical biology & drug design (01.03.2024)
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Journal Article
Design and synthesis of Fsp 3 -enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs
Sang, Zihao, Zhang, Tao, Wang, Zhao, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Published in Chemical biology & drug design (01.03.2024)
Published in Chemical biology & drug design (01.03.2024)
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Journal Article
5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation
Song, Hao, Xia, Yu, Zhang, Tao, Dun, Caiyun, Meng, Bairu, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Published in European journal of medicinal chemistry (05.11.2023)
Published in European journal of medicinal chemistry (05.11.2023)
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Spatiotemporal evolution analysis of human disturbances on giant panda: A new approach to study cumulative influences with large spatial scales
Zhigang, Yan, Dayananda, Buddhi, Popovic, Igor, Xueli, Wang, Dongwei, Kang, Yubo, Zhang, Guozhen, Sheng
Published in Ecological informatics (01.07.2023)
Published in Ecological informatics (01.07.2023)
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Tumor‐Selective Activation of Toll‐Like Receptor 7/8 Agonist Nano‐Immunomodulator Generates Safe Anti‐Tumor Immune Responses upon Systemic Administration
Hao, Yanyun, Li, Hui, Ge, Xiaoyan, Liu, Yang, Li, Xia, Liu, Yutong, Chen, Hongfei, Zhang, Shiying, Zou, Jing, Huang, Lingling, Zhao, Fabao, Kang, Dongwei, De Geest, Bruno G., Zhang, Zhiyue
Published in Angewandte Chemie International Edition (23.12.2022)
Published in Angewandte Chemie International Edition (23.12.2022)
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Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses
Li, Ping, Ju, Han, Zhang, Ying, Achi, Jazmin Galvan, Kang, Dongwei, Zou, Jinmi, Du, Ruikun, Cui, Qinghua, Liu, Xinyong, Rong, Lijun, Zhan, Peng
Published in Journal of medical virology (01.07.2023)
Published in Journal of medical virology (01.07.2023)
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Journal Article
Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors
Wu, Gaochan, Gao, Yun, Kang, Dongwei, Huang, Boshi, Huo, Zhipeng, Liu, Huiqing, Poongavanam, Vasanthanathan, Zhan, Peng, Liu, Xinyong
Published in MedChemComm (01.01.2018)
Published in MedChemComm (01.01.2018)
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Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV‑1 Capsid Inhibitors with Improved Antiviral Activities
Sun, Lin, Dick, Alexej, Meuser, Megan E, Huang, Tianguang, Zalloum, Waleed A, Chen, Chin-Ho, Cherukupalli, Srinivasulu, Xu, Shujing, Ding, Xiao, Gao, Ping, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene3,2-dpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation
Zhuo, Zongji, Wang, Zhao, Jing, Lanlan, Zhang, Tao, Ge, Anchao, Zhou, Zhenzhen, Liu, Ying, Li, Xin, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in International journal of molecular sciences (20.08.2024)
Published in International journal of molecular sciences (20.08.2024)
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Journal Article
Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase
Martín-Alonso, Samara, Kang, Dongwei, Martínez del Río, Javier, Luczkowiak, Joanna, Frutos-Beltrán, Estrella, Zhang, Lina, Cheng, Xiqiang, Liu, Xinyong, Zhan, Peng, Menéndez-Arias, Luis
Published in Journal of molecular biology (15.04.2022)
Published in Journal of molecular biology (15.04.2022)
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Journal Article
Identification of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase
Feng, Da, Zuo, Xiaofang, Zhao, Fabao, Lin, Hao, Dai, Jiaojiao, Sun, Yangyin, Clercq, Erik De, Pannecouque, Christophe, Kang, Dongwei, Liu, Xinyong, Zhan, Peng
Published in European journal of medicinal chemistry (05.02.2023)
Published in European journal of medicinal chemistry (05.02.2023)
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Journal Article
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability
Ju, Han, Murugan, N. Arul, Hou, Lingxin, Li, Ping, Guizzo, Laura, Zhang, Ying, Bertagnin, Chiara, Kong, Xiujie, Kang, Dongwei, Jia, Ruifang, Ma, Xiuli, Du, Ruikun, Poongavanam, Vasanthanathan, Loregian, Arianna, Huang, Bing, Liu, Xinyong, Zhan, Peng
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Journal Article
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs
Wang, Zhao, Yu, Zhao, Kang, Dongwei, Zhang, Jian, Tian, Ye, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Published in Bioorganic & medicinal chemistry (01.02.2019)
Published in Bioorganic & medicinal chemistry (01.02.2019)
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Journal Article
Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV‑1 NNRTIs
Sun, Yanying, Zhou, Zhenzhen, Feng, Da, Jing, Lanlan, Zhao, Fabao, Wang, Zhao, Zhang, Tao, Lin, Hao, Song, Hao, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Kang, Dongwei
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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Journal Article
Iterative Optimization and Structure–Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity
Ju, Han, Hou, Lingxin, Zhao, Fabao, Zhang, Ying, Jia, Ruifang, Guizzo, Laura, Bonomini, Anna, Zhang, Jiwei, Gao, Zhen, Liang, Ruipeng, Bertagnin, Chiara, Kong, Xiujie, Ma, Xiuli, Kang, Dongwei, Loregian, Arianna, Huang, Bing, Liu, Xinyong, Zhan, Peng
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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Journal Article
Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility
Wang, Zhao, Kang, Dongwei, Feng, Da, Cherukupalli, Srinivasulu, Jiang, Xiangyi, Fu, Zhipeng, De Clercq, Erik, Pannecouque, Christophe, Liu, Xinyong, Zhan, Peng
Published in European journal of medicinal chemistry (15.11.2020)
Published in European journal of medicinal chemistry (15.11.2020)
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Journal Article
Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein
Jiang, Xiangyi, Sharma, Prem Prakash, Rathi, Brijesh, Ji, Xiangkai, Hu, Lide, Gao, Zhen, Kang, Dongwei, Wang, Zhao, Xie, Minghui, Xu, Shujing, Zhang, Xujie, De Clercq, Erik, Cocklin, Simon, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Published in Journal of medical virology (01.12.2022)
Published in Journal of medical virology (01.12.2022)
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