Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
Mikami, Satoshi, Sasaki, Shigekazu, Asano, Yasutomi, Ujikawa, Osamu, Fukumoto, Shoji, Nakashima, Kosuke, Oki, Hideyuki, Kamiguchi, Naomi, Imada, Haruka, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor
Harada, Akina, Suzuki, Kazunori, Kamiguchi, Naomi, Miyamoto, Maki, Tohyama, Kimio, Nakashima, Kosuke, Taniguchi, Takahiko, Kimura, Haruhide
Published in PloS one (27.03.2015)
Published in PloS one (27.03.2015)
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Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Yoshikawa, Masato, Kamisaki, Haruhi, Kunitomo, Jun, Oki, Hideyuki, Kokubo, Hironori, Suzuki, Akihiro, Ikemoto, Tomomi, Nakashima, Kosuke, Kamiguchi, Naomi, Harada, Akina, Kimura, Haruhide, Taniguchi, Takahiko
Published in Bioorganic & medicinal chemistry (15.11.2015)
Published in Bioorganic & medicinal chemistry (15.11.2015)
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A 96-Well Plate Assay for CYP4503A Induction Using Cryopreserved Human Hepatocytes
KAMIGUCHI, Naomi, AOYAMA, Eiji, OKUDA, Teruaki, MORIWAKI, Toshiya
Published in Drug metabolism and disposition (01.11.2010)
Published in Drug metabolism and disposition (01.11.2010)
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Characterization of the CYP2C8 Active Site by Homology Modeling
Tanaka, Toshimasa, Kamiguchi, Naomi, Okuda, Teruaki, Yamamoto, Yoshio
Published in Chemical & Pharmaceutical Bulletin (01.07.2004)
Published in Chemical & Pharmaceutical Bulletin (01.07.2004)
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Discovery of 142-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor
Kunitomo, Jun, Yoshikawa, Masato, Fushimi, Makoto, Kawada, Akira, Quinn, John F., Oki, Hideyuki, Kokubo, Hironori, Kondo, Mitsuyo, Nakashima, Kosuke, Kamiguchi, Naomi, Suzuki, Kazunori, Kimura, Haruhide, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (27.11.2014)
Published in Journal of medicinal chemistry (27.11.2014)
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Discovery of Clinical Candidate N‑((1S)‑1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3‑b]pyrazine-4(1H)‑carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
Mikami, Satoshi, Nakamura, Shinji, Ashizawa, Tomoko, Nomura, Izumi, Kawasaki, Masanori, Sasaki, Shigekazu, Oki, Hideyuki, Kokubo, Hironori, Hoffman, Isaac D, Zou, Hua, Uchiyama, Noriko, Nakashima, Kosuke, Kamiguchi, Naomi, Imada, Haruka, Suzuki, Noriko, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Discovery of 1‑[2-Fluoro-4-(1H‑pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl‑1H‑pyrazol-5-yl)pyridazin-4(1H)‑one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor
Kunitomo, Jun, Yoshikawa, Masato, Fushimi, Makoto, Kawada, Akira, Quinn, John F, Oki, Hideyuki, Kokubo, Hironori, Kondo, Mitsuyo, Nakashima, Kosuke, Kamiguchi, Naomi, Suzuki, Kazunori, Kimura, Haruhide, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A
Harada, Akina, Suzuki, Kazunori, Miura, Shotaro, Hasui, Tomoaki, Kamiguchi, Naomi, Ishii, Tsuyoshi, Taniguchi, Takahiko, Kuroita, Takanobu, Takano, Akihiro, Stepanov, Vladimir, Halldin, Christer, Kimura, Haruhide
Published in Nuclear medicine and biology (01.02.2015)
Published in Nuclear medicine and biology (01.02.2015)
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