15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5[S]
Perry, Steven C., Kalyanaraman, Chakrapani, Tourdot, Benjamin E., Conrad, William S., Akinkugbe, Oluwayomi, Freedman, John Cody, Holinstat, Michael, Jacobson, Matthew P., Holman, Theodore R.
Published in Journal of lipid research (01.07.2020)
Published in Journal of lipid research (01.07.2020)
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Journal Article
Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
Bisignano, Paola, Ghezzi, Chiara, Jo, Hyunil, Polizzi, Nicholas F, Althoff, Thorsten, Kalyanaraman, Chakrapani, Friemann, Rosmarie, Jacobson, Matthew P, Wright, Ernest M, Grabe, Michael
Published in Nature communications (07.12.2018)
Published in Nature communications (07.12.2018)
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Journal Article
Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides
Rezai, Taha, Bock, Jonathan E, Zhou, Mai V, Kalyanaraman, Chakrapani, Lokey, R. Scott, Jacobson, Matthew P
Published in Journal of the American Chemical Society (01.11.2006)
Published in Journal of the American Chemical Society (01.11.2006)
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Journal Article
Molecular mechanics methods for predicting protein-ligand binding
Huang, Niu, Kalyanaraman, Chakrapani, Bernacki, Katarzyna, Jacobson, Matthew P
Published in Physical chemistry chemical physics : PCCP (01.01.2006)
Published in Physical chemistry chemical physics : PCCP (01.01.2006)
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Journal Article
High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex
Taylor, Isabelle R., Dunyak, Bryan M., Komiyama, Tomoko, Shao, Hao, Ran, Xu, Assimon, Victoria A., Kalyanaraman, Chakrapani, Rauch, Jennifer N., Jacobson, Matthew P., Zuiderweg, Erik R.P., Gestwicki, Jason E.
Published in The Journal of biological chemistry (16.03.2018)
Published in The Journal of biological chemistry (16.03.2018)
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Journal Article
Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Long, Thavy, Neitz, R Jeffrey, Beasley, Rachel, Kalyanaraman, Chakrapani, Suzuki, Brian M, Jacobson, Matthew P, Dissous, Colette, McKerrow, James H, Drewry, David H, Zuercher, William J, Singh, Rahul, Caffrey, Conor R
Published in PLoS neglected tropical diseases (01.01.2016)
Published in PLoS neglected tropical diseases (01.01.2016)
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Journal Article
A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection
NDAO, Momar, NATH-CHOWDHURY, Milli, KALYANARAMAN, Chakrapani, McKERROW, James H, ARROWOOD, Michael J, CAFFREY, Conor R, SAJID, Mohammed, MARCUS, Victoria, MASHIYAMA, Susan T, SAKANARI, Judy, CHOW, Eric, MACKEY, Zachary, LAND, Kirkwood M, JACOBSON, Matthew P
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2
Jameson, 2nd, J Brian, Kantz, Auric, Schultz, Lena, Kalyanaraman, Chakrapani, Jacobson, Matthew P, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R
Published in PloS one (11.08.2014)
Published in PloS one (11.08.2014)
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Journal Article
Evolution of Enzymatic Activities in the Enolase Superfamily: Galactarate Dehydratase III from Agrobacterium tumefaciens C58
Groninger-Poe, Fiona P, Bouvier, Jason T, Vetting, Matthew W, Kalyanaraman, Chakrapani, Kumar, Ritesh, Almo, Steven C, Jacobson, Matthew P, Gerlt, John A
Published in Biochemistry (Easton) (01.07.2014)
Published in Biochemistry (Easton) (01.07.2014)
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Journal Article
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily
Lukk, Tiit, Sakai, Ayano, Kalyanaraman, Chakrapani, Brown, Shoshana D, Imker, Heidi J, Song, Ling, Fedorov, Alexander A, Fedorov, Elena V, Toro, Rafael, Hillerich, Brandan, Seidel, Ronald, Patskovsky, Yury, Vetting, Matthew W, Nair, Satish K, Babbitt, Patricia C, Almo, Steven C, Gerlt, John A, Jacobson, Matthew P
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2012)
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Journal Article
Prediction and assignment of function for a divergent N -succinyl amino acid racemase
Jacobson, Matthew P, Gerlt, John A, Song, Ling, Kalyanaraman, Chakrapani, Fedorov, Alexander A, Fedorov, Elena V, Glasner, Margaret E, Brown, Shoshana, Imker, Heidi J, Babbitt, Patricia C, Almo, Steven C
Published in Nature chemical biology (01.08.2007)
Published in Nature chemical biology (01.08.2007)
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Journal Article
Discovery of a Dipeptide Epimerase Enzymatic Function Guided by Homology Modeling and Virtual Screening
Kalyanaraman, Chakrapani, Imker, Heidi J., Fedorov, Alexander A., Fedorov, Elena V., Glasner, Margaret E., Babbitt, Patricia C., Almo, Steven C., Gerlt, John A., Jacobson, Matthew P.
Published in Structure (London) (12.11.2008)
Published in Structure (London) (12.11.2008)
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Journal Article
Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)
Shao, Hao, Li, Xiaokai, Moses, Michael A, Gilbert, Luke A, Kalyanaraman, Chakrapani, Young, Zapporah T, Chernova, Margarita, Journey, Sara N, Weissman, Jonathan S, Hann, Byron, Jacobson, Matthew P, Neckers, Len, Gestwicki, Jason E
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Journal Article
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor
Fink, Elissa A, Xu, Jun, Hübner, Harald, Braz, Joao M, Seemann, Philipp, Avet, Charlotte, Craik, Veronica, Weikert, Dorothee, Schmidt, Maximilian F, Webb, Chase M, Tolmachova, Nataliya A, Moroz, Yurii S, Xi-Ping Huang, Kalyanaraman, Chakrapani, Gahbauer, Stefan, Chen, Geng, Liu, Zheng, Jacobson, Matthew P, Irwin, John J, Bouvier, Michel, Du, Yang, Shoichet, Brian K, Basbaum, Allan I, Gmeiner, Peter
Published in Science (American Association for the Advancement of Science) (30.09.2022)
Published in Science (American Association for the Advancement of Science) (30.09.2022)
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Journal Article
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators
Freedman, Cody, Tran, Adrianne, Tourdot, Benjamin E, Kalyanaraman, Chakrapani, Perry, Steve, Holinstat, Michael, Jacobson, Matthew P, Holman, Theodore R
Published in Biochemistry (Easton) (19.05.2020)
Published in Biochemistry (Easton) (19.05.2020)
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Journal Article
Role of Human 15-Lipoxygenase‑2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase‑1
Perry, Steven C, Horn, Thomas, Tourdot, Benjamin E, Yamaguchi, Adriana, Kalyanaraman, Chakrapani, Conrad, William S, Akinkugbe, Oluwayomi, Holinstat, Michael, Jacobson, Matthew P, Holman, Theodore R
Published in Biochemistry (Easton) (27.10.2020)
Published in Biochemistry (Easton) (27.10.2020)
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Journal Article
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase
Aleem, Ansari Mukhtar, Tsai, Wan-Chen, Tena, Jennyfer, Alvarez, Gabriella, Deschamps, Joshua, Kalyanaraman, Chakrapani, Jacobson, Matthew P, Holman, Theodore
Published in Biochemistry (Easton) (12.02.2019)
Published in Biochemistry (Easton) (12.02.2019)
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