Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites
Kaltenbronn, James S, Hudspeth, J. P, Lunney, E. A, Michniewicz, B. M, Nicolaides, E. D, Repine, J. T, Roark, W. H, Stier, M. A, Tinney, F. J
Published in Journal of medicinal chemistry (01.02.1990)
Published in Journal of medicinal chemistry (01.02.1990)
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Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors
Doherty, Annette M, Sircar, Ila, Kornberg, Brian E, Quin, John, Winters, R. Thomas, Kaltenbronn, James S, Taylor, Michael D, Batley, Brian L, Rapundalo, Stephen R
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice
McNamara, Dennis J, Dobrusin, Ellen, Leonard, Daniele M, Shuler, Kevon R, Kaltenbronn, James S, Quin, John, Bur, Scott, Thomas, Charles E, Doherty, Annette M, Scholten, Jeffrey D, Zimmerman, Karen K, Gibbs, Barbara S, Gowan, Richard C, Latash, Michael P, Leopold, Wilbur R, Przybranowski, Sally A, Sebolt-Leopold, Judith S
Published in Journal of medicinal chemistry (10.10.1997)
Published in Journal of medicinal chemistry (10.10.1997)
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Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors
Shahripour, Aurash, Kaltenbronn, James S, Lunney, Elizabeth A, Steinbaugh, Bruce A, Hamby, James M, Hamilton, Harriet W, Sawyer, Tomi K, Humblet, Christine, Doherty, Annette M
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors
Lunney, Elizabeth A, Hamilton, Harriet W, Hodges, John C, Kaltenbronn, James S, Repine, Joseph T, Badasso, Mohammed, Cooper, Jon B, Dealwis, Chris, Wallace, Bonnie A
Published in Journal of medicinal chemistry (01.11.1993)
Published in Journal of medicinal chemistry (01.11.1993)
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Structure-activity relationships of the potent combined endothelinA/endothelinB receptor antagonist Ac-DDip16-Leu-Asp-Ile-Ile-Trp21 (PD 142893): development of endothelinB receptor selective antagonists
Cody, Wayne L, He, John X, DePue, Patricia L, Waite, Lisa A, Leonard, Daniele M, Sefler, Andrea M, Kaltenbronn, James S, Haleen, Stephen J, Walker, Donnelle M, Flynn, Michael A, Welch, Kathleen, Reynolds, Elwood E, Doherty, Annette M
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Journal Article
New inhibitors of human renin that contain novel replacements at the P2 site
Doherty, Annette M, Kaltenbronn, James S, Hudspeth, James P, Repine, Joseph T, Roark, William H, Sircar, Ila, Tinney, Frank J, Connolly, Cleo J, Hodges, John C
Published in Journal of medicinal chemistry (01.04.1991)
Published in Journal of medicinal chemistry (01.04.1991)
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Journal Article
Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues
Repine, Joseph T, Kaltenbronn, James S, Doherty, Annette M, Hamby, James M, Himmelsbach, Richard J, Kornberg, Brian E, Taylor, Michael D, Lunney, ELizabeth A, Humblet, Christine
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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Journal Article
Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate
Repine, Joseph T, Himmelsbach, Richard J, Hodges, John C, Kaltenbronn, James S, Sircar, Ila, Skeean, Richard W, Brennan, Sean T, Hurley, Timothy R, Lunney, Elizabeth
Published in Journal of medicinal chemistry (01.07.1991)
Published in Journal of medicinal chemistry (01.07.1991)
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Synthesis of a Bromine-Rich Marine Antibiotic
Hanessian, Stephen, Kaltenbronn, James S
Published in Journal of the American Chemical Society (01.10.1966)
Published in Journal of the American Chemical Society (01.10.1966)
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SEMISYNTHETIC PENICILLINS AND CEPHALOSPORINS CONTAINING THE SUBSTITUTED 6-VINYL-1, 2-DIHYDRO-2-OXO- AND 1, 4-DIHYDRO-4-OXO-3-PYRIDINECARBOXYLIC ACID SIDE CHAINS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS
DEJOHN, DANA, DOMAGALA, JOHN M., HASKELL, THEODORE H., HEIFETZ, CARL L., HUANG, GIN-GUEI, KALTENBRONN, JAMES S., KROLLS, ULDIS
Published in Journal of antibiotics (01.01.1985)
Published in Journal of antibiotics (01.01.1985)
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STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE POTENT COMBINED ENDOTHELIN-A ENDOTHELIN-B RECEPTOR ANTAGONIST AC-DDIP(16)-LEU-ASP-ILE-ILE-TRP(21) - DEVELOPMENT OF ENDOTHELIN-B RECEPTOR-SELECTIVE ANTAGONISTS
CODY, WL, HE, JX, DEPUE, PL, WAITE, LA, LEONARD, DM, SEFLER, AM, KALTENBRONN, JS, HALEEN, SJ, WALKER, DM, FLYNN, MA, WELCH, KM, REYNOLDS, EE, DOHERTY, AM
Published in Journal of medicinal chemistry (21.07.1995)
Published in Journal of medicinal chemistry (21.07.1995)
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Journal Article
Evaluation of Physicochemical Parameters Important to the Oral Bioavailability of Peptide-like Compounds: Implications for the Synthesis of Renin Inhibitors
Hamilton, Harriet W, Steinbaugh, Bruce A, Stewart, Barbra H, Chan, O. Helen, Schmid, Heidi L, Schroeder, Richard, Ryan, Michael J, Keiser, Joan, Taylor, Michael D
Published in Journal of medicinal chemistry (01.04.1995)
Published in Journal of medicinal chemistry (01.04.1995)
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