Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Horne, Daniel B, Biswas, Kaustav, Brown, James, Bartberger, Michael D, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R, Lehto, Sonya G, Liu, Qingyian, Ma, Vu V, Monenschein, Holger, Nguyen, Thomas T, Yuan, Chester C, Youngblood, Beth D, Zhang, Maosheng, Zhong, Wenge, Allen, Jennifer R, Chen, Jian Jeffrey, Gavva, Narender R
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe
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Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Synthesis and structure–activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors
Reichelt, Andreas, Bailis, Julie M., Bartberger, Michael D., Yao, Guomin, Shu, Hong, Kaller, Matthew R., Allen, John G., Weidner, Margaret F., Keegan, Kathleen S., Dao, Jennifer H.
Published in European journal of medicinal chemistry (10.06.2014)
Published in European journal of medicinal chemistry (10.06.2014)
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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid
Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists
Horne, Daniel B, Tamayo, Nuria A, Bartberger, Michael D, Bo, Yunxin, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Kaller, Matthew R, Lehto, Sonya G, Ma, Vu V, Nishimura, Nobuko, Nguyen, Thomas T, Tang, Phi, Wang, Weiya, Youngblood, Beth D, Zhang, Maosheng, Gavva, Narender R, Monenschein, Holger, Norman, Mark H
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
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Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility
Rzasa, Robert M., Frohn, Michael J., Andrews, Kristin L., Chmait, Samer, Chen, Ning, Clarine, Jeffrey G., Davis, Carl, Eastwood, Heather A., Horne, Daniel B., Hu, Essa, Jones, Adrie D., Kaller, Matthew R., Kunz, Roxanne K., Miller, Silke, Monenschein, Holger, Nguyen, Thomas, Pickrell, Alexander J., Porter, Amy, Reichelt, Andreas, Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.
Published in Bioorganic & medicinal chemistry (01.12.2014)
Published in Bioorganic & medicinal chemistry (01.12.2014)
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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors
Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon
Harried, Scott S, Croghan, Michael D, Kaller, Matthew R, Lopez, Patricia, Zhong, Wenge, Hungate, Randall, Reider, Paul J
Published in Journal of organic chemistry (21.08.2009)
Published in Journal of organic chemistry (21.08.2009)
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Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors
Wood, Stephen, Wen, Paul H, Zhang, Jianhua, Zhu, Li, Luo, Yi, Babu-Khan, Safura, Chen, Kui, Pham, Roger, Esmay, Joel, Dineen, Thomas A, Kaller, Matthew R, Weiss, Matthew M, Hitchcock, Stephen A, Citron, Martin, Zhong, Wenge, Hickman, Dean, Williamson, Toni
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase
Kaller, Matthew R, Harried, Scott S, Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Graceffa, Russell, Hickman, Dean, Judd, Ted, Kriemen, Chuck, La, Daniel, Li, Vivian, Lopez, Patricia, Luo, Yi, Masse, Craig, Monenschein, Holger, Nguyen, Thomas, Pennington, Lewis D, Miguel, Tisha San, Sickmier, E. Allen, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, Williamson, Toni, Wood, Stephen, Xue, May, Yang, Bryant, Zhang, Jianhua, Patel, Vinod, Zhong, Wenge, Hitchcock, Stephen
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
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Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors
RZASA, Robert M, KALLER, Matthew R, XIAOLING XIONG, WENGE ZHONG, NORMAN, Mark H, GANG LIU, MAGAL, Ella, NGUYEN, Thomas T, OSSLUND, Timothy D, POWERS, David, SANTORA, Vincent J, VISWANADHAN, Vellarkad N, WANG, Hui-Ling
Published in Bioorganic & medicinal chemistry (15.10.2007)
Published in Bioorganic & medicinal chemistry (15.10.2007)
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Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors
Kaller, Matthew R., Zhong, Wenge, Henley, Charles, Magal, Ella, Nguyen, Thomas, Powers, David, Rzasa, Robert M., Wang, Weiya, Xiong, Xiaoling, Norman, Mark H.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Design and synthesis of quinolin-2(1 H)-one derivatives as potent CDK5 inhibitors
Zhong, Wenge, Liu, Hu, Kaller, Matthew R., Henley, Charles, Magal, Ella, Nguyen, Thomas, Osslund, Timothy D., Powers, David, Rzasa, Robert M., Wang, Hui-Ling, Wang, Weiya, Xiong, Xiaoling, Zhang, Jiandong, Norman, Mark H.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers
Horne, Daniel B., Bartberger, Michael D., Kaller, Matthew R., Monenschein, Holger, Zhong, Wenge, Hitchcock, Stephen A.
Published in Tetrahedron letters (30.09.2009)
Published in Tetrahedron letters (30.09.2009)
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MCL-1 단백질을 억제하는 화합물
LOW JONATHAN D, HARRINGTON PAUL E, BROWN SEAN P, LANMAN BRIAN ALAN, LI KEXUE, LI YUNXIAO, TAYGERLY JOSHUA, STEC MARKIAN M, KOHN TODD J, ASHTON KATE, PICKRELL ALEXANDER J, KALLER MATTHEW R, MINATTI ANA ELENA
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Year of Publication 26.12.2019
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AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS
CHEN JIAN J, QIAN WENYUAN, LIU QINGYIAN, FROHN MICHAEL J, ZHONG WENGE, RZASA ROBERT M, KALLER MATTHEW RICHARD, PICKRELL ALEXANDER J, ALLEN JENNIFER R, NGUYEN THOMAS T
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Year of Publication 05.03.2015
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Year of Publication 31.01.2018
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Year of Publication 31.01.2018
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Structure–activity relationships of 3,4-dihydro-1 H-quinazolin-2-one derivatives as potential CDK5 inhibitors
Rzasa, Robert M., Kaller, Matthew R., Liu, Gang, Magal, Ella, Nguyen, Thomas T., Osslund, Timothy D., Powers, David, Santora, Vincent J., Viswanadhan, Vellarkad N., Wang, Hui-Ling, Xiong, Xiaoling, Zhong, Wenge, Norman, Mark H.
Published in Bioorganic & medicinal chemistry (2007)
Published in Bioorganic & medicinal chemistry (2007)
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TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS
MA VU VAN, YUAN CHESTER CHENGUANG, ST. JEAN DAVID J. JR, GORE VIJAY KESHAV, CHEN JIAN J, BISWAS KAUSTAV, LIU QINGYIAN, HARRIED SCOTT, ZHONG WENGE, BROWN JAMES, MONENSCHEIN HOLGER, NGUYEN THOMAS T, HORNE DANIEL B, KALLER MATTHEW R
Year of Publication 16.04.2014
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Year of Publication 16.04.2014
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KIF18A INHIBITORS
XUE, Qiufen May, KALLER, Matthew Richard, NGUYEN, Thomas T, NISHIMURA, Nobuko, ALLEN, John Gordon, TAMAYO, Nuria A
Year of Publication 01.08.2024
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Year of Publication 01.08.2024
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