Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart
Vagnozzi, Ronald J, Gatto, Jr, Gregory J, Kallander, Lara S, Hoffman, Nicholas E, Mallilankaraman, Karthik, Ballard, Victoria L T, Lawhorn, Brian G, Stoy, Patrick, Philp, Joanne, Graves, Alan P, Naito, Yoshiro, Lepore, John J, Gao, Erhe, Madesh, Muniswamy, Force, Thomas
Published in Science translational medicine (16.10.2013)
Published in Science translational medicine (16.10.2013)
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Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B‑Raf
Patterson, Jaclyn R, Graves, Alan P, Stoy, Patrick, Cheung, Mui, Desai, Tina A, Fries, Harvey, Gatto, Gregory J, Holt, Dennis A, Shewchuk, Lisa, Totoritis, Rachel, Wang, Liping, Kallander, Lara S
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
4,6-Diaminopyrimidines as Highly Preferred Troponin I‑Interacting Kinase (TNNI3K) Inhibitors
Philp, Joanne, Lawhorn, Brian G, Graves, Alan P, Shewchuk, Lisa, Rivera, Katrina L, Jolivette, Larry J, Holt, Dennis A, Gatto, Gregory J, Kallander, Lara S
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Substituent Effects on Drug–Receptor H‑bond Interactions: Correlations Useful for the Design of Kinase Inhibitors
Lawhorn, Brian G, Philp, Joanne, Graves, Alan P, Holt, Dennis A, Gatto, Gregory J, Kallander, Lara S
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
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Journal Article
Identification of Purines and 7‑Deazapurines as Potent and Selective Type I Inhibitors of Troponin I‑Interacting Kinase (TNNI3K)
Lawhorn, Brian G, Philp, Joanne, Zhao, Yongdong, Louer, Christopher, Hammond, Marlys, Cheung, Mui, Fries, Harvey, Graves, Alan P, Shewchuk, Lisa, Wang, Liping, Cottom, Joshua E, Qi, Hongwei, Zhao, Huizhen, Totoritis, Rachel, Zhang, Guofeng, Schwartz, Benjamin, Li, Hu, Sweitzer, Sharon, Holt, Dennis A, Gatto, Gregory J, Kallander, Lara S
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders
Vantourout, Julien C, Mason, Andrew M, Yuen, Josephine, Simpson, Graham L, Evindar, Ghotas, Kuai, Letian, Hobbs, Michael, Edgar, Emma, Needle, Saul, Bai, Xiaopeng, Wilson, Steve, Scott-Stevens, Paul, Traylen, William, Lambert, Kim, Young, Neil, Bunally, Shenaz, Summerfield, Scott G, Snell, Richard, Lad, Rakesh, Shi, Eric, Skinner, Steven, Shewchuk, Lisa, Watson, Allan J.B, Chung, Chun-wa, Pal, Sandeep, Holt, Dennis A, Kallander, Lara S, Prendergast, Joanne, Rivera, Katrina, Washburn, David G, Harpel, Mark R, Arico-Muendel, Christopher, Isidro-Llobet, Albert
Published in Bioconjugate chemistry (17.02.2021)
Published in Bioconjugate chemistry (17.02.2021)
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Journal Article
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1
Kallander, Lara S., Washburn, David, Hilfiker, Mark A., Eidam, Hilary Schenck, Lawhorn, Brian G., Prendergast, Joanne, Fox, Ryan, Dowdell, Sarah, Manns, Sharada, Hoang, Tram, Zhao, Steve, Ye, Guosen, Hammond, Marlys, Holt, Dennis A., Roethke, Theresa, Hong, Xuan, Reid, Robert A., Gampe, Robert, Zhang, Hong, Diaz, Elsie, Rendina, Alan R., Quinn, Amy M., Willette, Bob
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition
Lawhorn, Brian G., Tran, Tritin, Hong, Victor S., Morgan, Lisa A., Le, BaoChau T., Harpel, Mark R., Jolivette, Larry, Diaz, Elsie, Schwartz, Benjamin, Gross, Jeffrey W., Tomaszek, Thaddeus, Semus, Simon, Concha, Nestor, Smallwood, Angela, Holt, Dennis A., Kallander, Lara S.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo
Kallander, Lara S, Lu, Qing, Chen, Wenfang, Tomaszek, Thaddeus, Yang, Guang, Tew, David, Meek, Thomas D, Hofmann, Glenn A, Schulz-Pritchard, Christina K, Smith, Ward W, Janson, Cheryl A, Ryan, M. Dominic, Zhang, Gui-Feng, Johanson, Kyung O, Kirkpatrick, Robert B, Ho, Thau F, Fisher, Paul W, Mattern, Michael R, Johnson, Randall K, Hansbury, Michael J, Winkler, James D, Ward, Keith W, Veber, Daniel F, Thompson, Scott K
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
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Journal Article
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages
Marino, Joseph P., Kallander, Lara S., Ma, Chun, Oh, Hye-Ja, Lee, Dennis, Gaitanopoulos, Dimitri E., Krawiec, John A., Parks, Derek J., Webb, Christine L., Ziegler, Kelly, Jaye, Michael, Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Improving the developability profile of pyrrolidine progesterone receptor partial agonists
Kallander, Lara S., Washburn, David G., Hoang, Tram H., Frazee, James S., Stoy, Patrick, Johnson, Latisha, Lu, Qing, Hammond, Marlys, Barton, Linda S., Patterson, Jaclyn R., Azzarano, Leonard M., Nagilla, Rakesh, Madauss, Kevin P., Williams, Shawn P., Stewart, Eugene L., Duraiswami, Chaya, Grygielko, Eugene T., Xu, Xiaoping, Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
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Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists
Jones, David G., Liang, Xi, Stewart, Eugene L., Noe, Robert A., Kallander, Lara S., Madauss, Kevin P., Williams, Shawn P., Thompson, Scott K., Gray, David W., Hoekstra, William J.
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
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Journal Article
HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
HOANG TRAM H, LAWHORN BRIAN GRIFFIN, YE GUOSEN, DOWDELL SARAH E, ELBAN MARK, KALLANDER LARA S, WASHBURN DAVID G, PHILP JOANNE, HILFIKER MARK A, MANNS SHARADA, HAMMOND MARLYS, FOX RYAN MICHAEL, EIDAM HILARY SCHENCK
Year of Publication 12.09.2016
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Year of Publication 12.09.2016
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