MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
Karsten, Stella, Fiskesund, Roland, Zhang, Xing-Mei, Marttila, Petra, Sanjiv, Kumar, Pham, Therese, Rasti, Azita, Bräutigam, Lars, Almlöf, Ingrid, Marcusson-Ståhl, Maritha, Sandman, Carolina, Platzack, Björn, Harris, Robert A., Kalderén, Christina, Cederbrant, Karin, Helleday, Thomas, Warpman Berglund, Ulrika
Published in Cell death and differentiation (01.01.2022)
Published in Cell death and differentiation (01.01.2022)
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Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
Tanner, Lloyd, Bergwik, Jesper, Bhongir, Ravi K. V., Pan, Lang, Dong, Caijuan, Wallner, Olov, Kalderén, Christina, Helleday, Thomas, Boldogh, Istvan, Adner, Mikael, Egesten, Arne
Published in Frontiers in pharmacology (17.10.2022)
Published in Frontiers in pharmacology (17.10.2022)
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Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule
Kitambi, Satish Srinivas, Toledo, Enrique M, Usoskin, Dmitry, Wee, Shimei, Harisankar, Aditya, Svensson, Richard, Sigmundsson, Kristmundur, Kalderen, Christina, Niklasson, Mia, Kundu, Soumi, Aranda, Sergi, Westermark, Bengt, Uhrbom, Lene, Andaeng, Michael, Damberg, Peter, Nelander, Sven, Arenas, Ernest, Artursson, Per, Walfridsson, Julian, Nilsson, Karin sberg, Hammarstrom, Lars GJ, Ernfors, Patrik
Published in Cell (10.04.2014)
Published in Cell (10.04.2014)
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Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere, Marianna, Pettke, Aleksandra, Salata, Cristiano, Wallner, Olov, Koolmeister, Tobias, Cazares-Körner, Armando, Visnes, Torkild, Hesselman, Maria Carmen, Kunold, Elena, Wiita, Elisee, Kalderén, Christina, Lightowler, Molly, Jemth, Ann-Sofie, Lehtiö, Janne, Rosenquist, Åsa, Warpman-Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Jafari, Rozbeh, Puumalainen, Marjo-Riitta
Published in Viruses (10.12.2020)
Published in Viruses (10.12.2020)
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Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J, Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars
Published in Oncotarget (17.10.2017)
Published in Oncotarget (17.10.2017)
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Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1
Wallner, Olov, Cázares‐Körner, Armando, Scaletti, Emma Rose, Masuyer, Geoffrey, Bekkhus, Tove, Visnes, Torkild, Mamonov, Kirill, Ortis, Florian, Lundbäck, Thomas, Volkova, Maria, Koolmeister, Tobias, Wiita, Elisée, Loseva, Olga, Pandey, Monica, Homan, Evert, Benítez‐Buelga, Carlos, Davies, Jonathan, Scobie, Martin, Warpman Berglund, Ulrika, Kalderén, Christina, Stenmark, Pål, Helleday, Thomas, Michel, Maurice
Published in ChemMedChem (03.01.2023)
Published in ChemMedChem (03.01.2023)
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CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2
Kalderén, Christina, Stadler, Charlotte, Forsgren, Margareta, Kvastad, Linda, Johansson, Elin, Sydow-Bäckman, Mona, Svensson Gelius, Stefan
Published in International immunopharmacology (01.05.2014)
Published in International immunopharmacology (01.05.2014)
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A truncated analogue of CCL2 mediates anti-fibrotic effects on murine fibroblasts independently of CCR2
Kalderén, Christina, Forsgren, Margareta, Karlström, Ulla, Stefansson, Karin, Svensson, Robert, Berglund, Magnus M., Palm, Gunnar, Selander, Martin, Sundbom, Maj, Nilsson, Joakim, Sjögren, Annelie, Zachrisson, Kristina, Gelius, Stefan Svensson
Published in Biochemical pharmacology (01.03.2012)
Published in Biochemical pharmacology (01.03.2012)
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Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library
Forsman, Huamei, Kalderén, Christina, Nordin, Anna, Nordling, Erik, Jensen, Annika Jernmalm, Dahlgren, Claes
Published in Biochemical pharmacology (01.02.2011)
Published in Biochemical pharmacology (01.02.2011)
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
Michel, Maurice, Benítez-Buelga, Carlos, Calvo, Patricia A., Hanna, Bishoy M. F., Mortusewicz, Oliver, Masuyer, Geoffrey, Davies, Jonathan, Wallner, Olov, Sanjiv, Kumar, Albers, Julian J., Castañeda-Zegarra, Sergio, Jemth, Ann-Sofie, Visnes, Torkild, Sastre-Perona, Ana, Danda, Akhilesh N., Homan, Evert J., Marimuthu, Karthick, Zhenjun, Zhao, Chi, Celestine N., Sarno, Antonio, Wiita, Elisée, von Nicolai, Catharina, Komor, Anna J., Rajagopal, Varshni, Müller, Sarah, Hank, Emily C., Varga, Marek, Scaletti, Emma R., Pandey, Monica, Karsten, Stella, Haslene-Hox, Hanne, Loevenich, Simon, Marttila, Petra, Rasti, Azita, Mamonov, Kirill, Ortis, Florian, Schömberg, Fritz, Loseva, Olga, Stewart, Josephine, D’Arcy-Evans, Nicholas, Koolmeister, Tobias, Henriksson, Martin, Michel, Dana, de Ory, Ana, Acero, Lucia, Calvete, Oriol, Scobie, Martin, Hertweck, Christian, Vilotijevic, Ivan, Kalderén, Christina, Osorio, Ana, Perona, Rosario, Stolz, Alexandra, Stenmark, Pål, Berglund, Ulrika Warpman, de Vega, Miguel, Helleday, Thomas
Published in Science (American Association for the Advancement of Science) (2022)
Published in Science (American Association for the Advancement of Science) (2022)
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Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas
Published in Nucleic acids research (02.12.2020)
Published in Nucleic acids research (02.12.2020)
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Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics
Lallo, Alice, Gulati, Sakshi, Schenk, Maximilian W, Khandelwal, Garima, Berglund, Ulrika Warpman, Pateras, Ioannis S, Chester, Christopher P E, Pham, Therese M, Kalderen, Christina, Frese, Kristopher K, Gorgoulis, Vassilis G, Miller, Crispin, Blackhall, Fiona, Helleday, Thomas, Dive, Caroline
Published in British journal of pharmacology (01.02.2019)
Published in British journal of pharmacology (01.02.2019)
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RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule
Kitambi, Satish Srinivas, Toledo, Enrique M, Usoskin, Dmitry, Wee, Shimei, Harisankar, Aditya, Svensson, Richard, Sigmundsson, Kristmundur, Kalderén, Christina, Niklasson, Mia, Kundu, Soumi, Aranda, Sergi, Westermark, Bengt, Uhrbom, Lene, Andäng, Michael, Damberg, Peter, Nelander, Sven, Arenas, Ernest, Artursson, Per, Walfridsson, Julian, Forsberg Nilsson, Karin, Hammarström, Lars G J, Ernfors, Patrik
Published in Cell (10.04.2014)
Published in Cell (10.04.2014)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Puigvert, Jordi Carreras, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jensen, Annika Jenmalm, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin, Berglund, Ulrika Warpman, Helleday, Thomas
Published in Nature (London) (10.04.2014)
Published in Nature (London) (10.04.2014)
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Abstract 4799: OGG1 depleted cancer cells are sensitive to anti-malarial drug proguanil: Repurposing for cancer treatment
Rajagopal, Varshni, Marimuthu, Karthick, Benitez-Buelga, Carlos, Wallner, Olov, Homan, Evert, Scobie, Martin, Kalderén, Christina, Helleday, Thomas, Berglund, Ulrika Warpman, Sanjiv, Kumar
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Front Cover: Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)
Wallner, Olov, Cázares‐Körner, Armando, Scaletti, Emma Rose, Masuyer, Geoffrey, Bekkhus, Tove, Visnes, Torkild, Mamonov, Kirill, Ortis, Florian, Lundbäck, Thomas, Volkova, Maria, Koolmeister, Tobias, Wiita, Elisée, Loseva, Olga, Pandey, Monica, Homan, Evert, Benítez‐Buelga, Carlos, Davies, Jonathan, Scobie, Martin, Warpman Berglund, Ulrika, Kalderén, Christina, Stenmark, Pål, Helleday, Thomas, Michel, Maurice
Published in ChemMedChem (03.01.2023)
Published in ChemMedChem (03.01.2023)
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Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Sanjiv, Kumar, gad, Helge, Rudd, Sean G., Mortusewicz, Oliver, Stolz, Ailine, Amaral, Nuno, Brautigham, Lars, Pudelko, Linda, Kaldéren, Christina, Jemth, Ann-Sofie, Almlöf, Ingrid, Visnes, Torkild, Schultz, Niklas, Boström, Johan, Montano1, José Manuel Calderon, Hagenkort, Anna, Groth, Petra, Gokturk, Camilla, Koolmeister, Tobias, Wakchaure, Prasad, Homan, Evert, Altun, Mikael, Ström, Cecilia, Scobie, Martin, Bastians, Holger, Berglund, Ulrika Warpman, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas, Nadilly, Gustafsson, Nina M S, Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisée, Borhade, Sanjay, Green, Alanna C, Vallin, Karl S A, Sarno, Antonio, Svensson, Richard, Göktürk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E, Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R, Bengtsson, Christoffer, Paulin, Cynthia B J, Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Färnegårdh, Katarina, Krämer, Andreas, Garg, Neeraj, Michel, Maurice, Häggblad, Sara, Jarvius, Malin, Kalderén, Christina, Jensen, Amanda Bögedahl, Almlöf, Ingrid, Karsten, Stella, Zhang, Si Min, Häggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Björn, Nekhotiaeva, Natalia, Klingegård, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjöberg, Birger, Vargas, Irene L, Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E, Arvidsson, Per I, Scobie, Martin, Meiser, Johannes, Stenmark, Pål, Berglund, Ulrika Warpman, Homan, Evert J, Helleday, Thomas
Published in Nature cancer (2022)
Published in Nature cancer (2022)
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Erratum: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 (Oncotarget (2017) 8 (84671-84684) DOI: 10.18632/oncotarget.19404)
Pudelko, L., Rouhi, P., Sanjiv, K., Gad, H., Kalderén, C., Höglund, A., Squatrito, M., Schuhmacher, A. J., Edwards, Steven, Hägerstrand, D., Berglund, U. W., Helleday, T., Bräutigam, L.
Published in Oncotarget (25.02.2020)
Published in Oncotarget (25.02.2020)
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