Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]
Niesor, Eric J., Magg, Christine, Ogawa, Naoto, Okamoto, Hiroshi, von der Mark, Elisabeth, Matile, Hugues, Schmid, Georg, Clerc, Roger G., Chaput, Evelyne, Blum-Kaelin, Denise, Huber, Walter, Thoma, Ralf, Pflieger, Philippe, Kakutani, Makoto, Takahashi, Daisuke, Dernick, Gregor, Maugeais, Cyrille
Published in Journal of lipid research (01.12.2010)
Published in Journal of lipid research (01.12.2010)
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Journal Article
JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice
Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Kobayashi, Akio, Ohta, Takeshi, Kakutani, Makoto, Imanaka, Tsuneo, Ogawa, Nobuya
Published in Journal of pharmacological sciences (01.09.2015)
Published in Journal of pharmacological sciences (01.09.2015)
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JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity
Okuma, Chihiro, Ohta, Takeshi, Tadaki, Hironobu, Hamada, Hiromi, Oda, Tomohiro, Taniuchi, Hideyuki, Yamanaka, Kenji, Ishii, Yukihito, Ohe, Yasuhiro, Yata, Shinji, Nishiu, Jun, Aratsu, Yusuke, Oshida, Shinichi, Kume, Shinichi, Kakutani, Makoto
Published in European journal of pharmacology (05.07.2015)
Published in European journal of pharmacology (05.07.2015)
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JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models
Mera, Yasuko, Kawai, Takashi, Ogawa, Naoto, Odani, Naoya, Sasase, Tomohiko, Miyajima, Katsuhiro, Ohta, Takeshi, Kakutani, Makoto
Published in Journal of pharmacological sciences (01.11.2015)
Published in Journal of pharmacological sciences (01.11.2015)
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Pharmacological characterization of diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an intestine-specific inhibitor of microsomal triglyceride transfer protein
Mera, Yasuko, Odani, Naoya, Kawai, Takashi, Hata, Takahiro, Suzuki, Masahiro, Hagiwara, Atsushi, Katsushima, Takeo, Kakutani, Makoto
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor
Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya
Published in Biological & pharmaceutical bulletin (2015)
Published in Biological & pharmaceutical bulletin (2015)
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JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis
Okuma, Chihiro, Ohta, Takeshi, Tadaki, Hironobu, Ishigure, Tatsuya, Sakata, Shohei, Taniuchi, Hideyuki, Sano, Ryuhei, Hamada, Hiromi, Kume, Shinichi, Nishiu, Jun, Kakutani, Makoto
Published in Journal of pharmacological sciences (01.07.2015)
Published in Journal of pharmacological sciences (01.07.2015)
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Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats
Okuma, Chihiro, Ohta, Takeshi, Ito, Makoto, Tadaki, Hironobu, Oda, Tomohiro, Kume, Shinichi, Nishiu, Jun, Kakutani, Makoto
Published in Journal of pharmacological sciences (01.02.2016)
Published in Journal of pharmacological sciences (01.02.2016)
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Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats
Sakata, Shohei, Katsumi, Sohei, Mera, Yasuko, Kuroki, Yukiharu, Nashida, Reiko, Kakutani, Makoto, Ohta, Takeshi
Published in Journal of pharmacological sciences (01.01.2015)
Published in Journal of pharmacological sciences (01.01.2015)
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Journal Article
Increased Expression of Lectinlike Oxidized Low Density Lipoprotein Receptor-1 in Initial Atherosclerotic Lesions of Watanabe Heritable Hyperlipidemic Rabbits
Chen, Mingyi, Kakutani, Makoto, Minami, Manabu, Kataoka, Hiroharu, Kume, Noriaki, Narumiya, Shuh, Kita, Toru, Masaki, Tomoh, Sawamura, Tatsuya
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2000)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2000)
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A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats
Ishii, Yukihito, Ohta, Takeshi, Sasase, Tomohiko, Morinaga, Hisayo, Hata, Takahiro, Miyajima, Katsuhiro, Katusda, Yoshiaki, Masuyama, Taku, Shinohara, Masami, Kakutani, Makoto, Matsushita, Mutsuyoshi
Published in Nutrition research (New York, N.Y.) (01.07.2010)
Published in Nutrition research (New York, N.Y.) (01.07.2010)
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JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Reduces Food Preference for Fat
Kakutani, Makoto, Kawai, Takashi, Tomimoto, Daisuke, Ishii, Yukihito, Hata, Takahiro, Mera, Yasuko, Ohta, Takeshi
Published in Journal of Diabetes Research (01.01.2014)
Published in Journal of Diabetes Research (01.01.2014)
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Journal Article
JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats
Ohta, Takeshi, Yamamoto, Hiromi, Sasase, Tomohiko, Mera, Yasuko, Ito, Makoto, Sakata, Shohei, Kakutani, Makoto
Published in Journal of Diabetes Research (01.01.2014)
Published in Journal of Diabetes Research (01.01.2014)
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Journal Article
Combination Therapy of an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein and Peroxisome Proliferator-Activated Receptor γ Agonist in Diabetic Rat
Kakutani, Makoto, Nashida, Reiko, Kuroki, Yukiharu, Mera, Yasuko, Sakata, Shohei, Ohta, Takeshi
Published in Journal of Diabetes Research (01.01.2014)
Published in Journal of Diabetes Research (01.01.2014)
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Journal Article
Pathophysiological Analysis of Female Spontaneously Diabetic Torii Fatty Rats
ISHII, Yukihito, OHTA, Takeshi, SASASE, Tomohiko, MORINAGA, Hisayo, UEDA, Nobuhisa, HATA, Takahiro, KAKUTANI, Makoto, MIYAJIMA, Katsuhiro, KATSUDA, Yoshiaki, MASUYAMA, Taku, SHINOHARA, Masami, MATSUSHITA, Mutsuyoshi
Published in Experimental Animals (01.01.2010)
Published in Experimental Animals (01.01.2010)
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Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Leprfa Rats
ISHII, Yukihito, MAKI, Mimi, YAMAMOTO, Hiromi, SASASE, Tomohiko, KAKUTANI, Makoto, OHTA, Takeshi
Published in Experimental Animals (2010)
Published in Experimental Animals (2010)
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Journal Article
Accumulation of LOX-1 Ligand in Plasma and Atherosclerotic Lesions of Watanabe Heritable Hyperlipidemic Rabbits: Identification by a Novel Enzyme Immunoassay
Kakutani, Makoto, Ueda, Makiko, Naruko, Takahiko, Masaki, Tomoh, Sawamura, Tatsuya
Published in Biochemical and biophysical research communications (23.03.2001)
Published in Biochemical and biophysical research communications (23.03.2001)
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