Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor
Iwatsuki, Yoshiyuki, Sato, Takayuki, Moritani, Yumiko, Shigenaga, Takeshi, Suzuki, Mami, Kawasaki, Tomihisa, Funatsu, Toshiyuki, Kaku, Seiji
Published in European journal of pharmacology (30.12.2011)
Published in European journal of pharmacology (30.12.2011)
Get full text
Journal Article
Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats
Hatanaka, Toshiki, Ukai, Masashi, Watanabe, Mai, Someya, Akiyoshi, Ohtake, Akiyoshi, Suzuki, Masanori, Ueshima, Koji, Sato, Shuichi, Kaku, Seiji
Published in Naunyn-Schmiedeberg's archives of pharmacology (2013)
Published in Naunyn-Schmiedeberg's archives of pharmacology (2013)
Get full text
Journal Article
Plasma factor Xa inhibition can predict antithrombotic effects of oral direct factor Xa inhibitors in rabbit atherothrombosis models
Funatsu, Toshiyuki, Yamashita, Atsushi, Kaku, Seiji, Iwatsuki, Yoshiyuki, Asada, Yujiro
Published in Thrombosis and haemostasis (01.11.2012)
Published in Thrombosis and haemostasis (01.11.2012)
Get more information
Journal Article
Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors
Koshio, Hiroyuki, Hirayama, Fukushi, Ishihara, Tsukasa, Shiraki, Ryouta, Shigenaga, Takeshi, Taniuchi, Yuta, Sato, Kazuo, Moritani, Yumiko, Iwatsuki, Yoshiyuki, Kaku, Seiji, Katayama, Naoko, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.02.2005)
Published in Bioorganic & medicinal chemistry (15.02.2005)
Get full text
Journal Article
Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives
Koshio, Hiroyuki, Hirayama, Fukushi, Ishihara, Tsukasa, Kaizawa, Hiroyuki, Shigenaga, Takeshi, Taniuchi, Yuta, Sato, Kazuo, Moritani, Yumiko, Iwatsuki, Yoshiyuki, Uemura, Toshio, Kaku, Seiji, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.10.2004)
Published in Bioorganic & medicinal chemistry (15.10.2004)
Get full text
Journal Article
Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template
Hirayama, Fukushi, Koshio, Hiroyuki, Katayama, Naoko, Ishihara, Tsukasa, Kaizawa, Hiroyuki, Taniuchi, Yuta, Sato, Kazuo, Sakai-Moritani, Yumiko, Kaku, Seiji, Kurihara, Hiroyuki, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (06.02.2003)
Published in Bioorganic & medicinal chemistry (06.02.2003)
Get full text
Journal Article
Design, synthesis and biological activity of YM-60828 derivatives: Potent and orally-bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates
HIRAYAMA, Fukushi, KOSHIO, Hiroyuki, SATO, Kazuo, SAKAI-MORITANI, Yumiko, KAKU, Seiji, KAWASAKI, Tomihisa, MATSUMOTO, Yuzo, SAKAMOTO, Shuichi, TSUKAMOTO, Shin-Ichi, ISHIHARA, Tsukasa, WATANUKI, Susumu, HACHIYA, Shunichiro, KAIZAWA, Hiroyuki, KURAMOCHI, Takahiro, KATAYAMA, Naoko, KURIHARA, Hiroyuki, TANIUCHI, Yuta
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
Get full text
Journal Article
Comparative Studies of a Humanized Anti-glycoprotein IIb/IIIa Monoclonal Antibody, YM337, and Abciximab on in Vitro Antiplatelet Effect and Binding Properties
Suzuki, Ken-ichi, Sato, Kazuo, Kamohara, Masazumi, Kaku, Seiji, Kawasaki, Tomihisa, Yano, Shinya, Iizumi, Yuichi
Published in Biological & pharmaceutical bulletin (01.08.2002)
Published in Biological & pharmaceutical bulletin (01.08.2002)
Get full text
Journal Article
INSERT NUT AND DEVICE
ONISHI, Hirokazu, NAGAI, Tomohiro, NEMOTO, Kazuyoshi, KAKU, Seiji, SUGAWARA, Hideharu
Year of Publication 21.03.2024
Get full text
Year of Publication 21.03.2024
Patent
Evaluation of a GPIIb/IIIa antagonist YM337 in a primate model of middle cerebral artery thrombosis
Kaku, Seiji, Umemura, Kazuo, Mizuno, Atsuhiro, Yano, Shinya, Suzuki, Ken-ichi, Kawasaki, Tomihisa, Nakashima, Mitsuyoshi
Published in European journal of pharmacology (19.03.1998)
Published in European journal of pharmacology (19.03.1998)
Get full text
Journal Article
Antithrombotic effect of YM-75466 is separated from its effect on bleeding time and coagulation time
Sato, Kazuo, Kaku, Seiji, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo, Kawasaki, Tomihisa, Iizumi, Yuichi
Published in European journal of pharmacology (03.07.1998)
Published in European journal of pharmacology (03.07.1998)
Get full text
Journal Article
Comparative studies on the antiplatelet effects of a humanized anti-platelet glycoprotein IIb/IIIa antibody (YM337) and ReoPro under flow conditions
Kuwahara, M, Sugimoto, M, Tsuji, S, Miyata, S, Nishio, K, Kaku, S, Suzuki, K, Kawasaki, T, Yoshioka, A
Published in Thrombosis and haemostasis (01.07.1998)
Published in Thrombosis and haemostasis (01.07.1998)
Get more information
Journal Article
Antithrombotic effects of YM466, a synthesized direct inhibitor of factor Xa, in an arterio-venous shunt thrombosis model in squirrel monkeys
Iwatsuki, Yoshiyuki, Kaku, Seiji, Moritani, Yumiko, Taniuchi, Yuta, Hirayama, Fukushi, Koshio, Hiroyuki, Matsumoto, Yuzo, Mano, Yuji, Kawasaki, Tomihisa
Published in Drug development research (01.02.2003)
Published in Drug development research (01.02.2003)
Get full text
Journal Article
Comparison of the antiplatelet effect of YM337 and abciximab in rhesus monkeys
SUZUKI, K.-I, SAKAI, Y, MASUHO, Y, HISAMICHI, N, TANIUCHI, Y, SATO, K, TERAZAKI, C, KAKU, S, KAWASAKI, T, YANO, S, INAGAKI, O
Published in European journal of pharmacology (08.10.1997)
Published in European journal of pharmacology (08.10.1997)
Get full text
Journal Article
Antithrombotic and anticoagulant effects of direct factor Xa inhibitor darexaban in rat and rabbit models of venous thrombosis
Kaku, Seiji, Uemura, Toshio, Saitoh, Minori, Suzuki, Ken-ichi, Iwatsuki, Yoshiyuki, Funatsu, Toshiyuki, Kawasaki, Tomihisa
Published in European journal of pharmacology (15.01.2013)
Published in European journal of pharmacology (15.01.2013)
Get full text
Journal Article
Enhancement of tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by combination with a humanized anti-glycoprotein IIb/IIIa monoclonal antibody, YM337, in a rhesus monkey model of coronary thrombosis
Kawasaki, T, Sato, K, Suzuki, K, Sakai, Y, Taniuchi, Y, Kaku, S, Yano, S, Inagaki, O, Tomioka, K, Masuho, Y, Yanagisawa, I, Takenaka, T
Published in Thrombosis and haemostasis (01.03.1998)
Published in Thrombosis and haemostasis (01.03.1998)
Get more information
Journal Article
Antiplatelet and antithrombotic effects of YM337, the Fab fragment of a humanized anti-GPIIb/IIIa monoclonal antibody in monkeys
Kaku, S, Kawasaki, T, Hisamichi, N, Sakai, Y, Taniuchi, Y, Inagaki, O, Yano, S, Suzuki, K, Terazaki, C, Masuho, Y, Satoh, N, Takenaka, T, Yanagi, K, Ohshima, N
Published in Thrombosis and haemostasis (1996)
Published in Thrombosis and haemostasis (1996)
Get more information
Journal Article