Design, Synthesis, and Biological Evaluation of a Novel Series of 4‑Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity
Ikeda, Zenichi, Kakegawa, Keiko, Kikuchi, Fumiaki, Itono, Sachiko, Oki, Hideyuki, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Kenichi, Watanabe, Masanori, Sasaki, Masako, Ishihara, Youko, Tohyama, Kimio, Kitazaki, Tomoyuki, Maekawa, Tsuyoshi, Sasaki, Minoru
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore
Tanaka, Yuta, Seto, Masaki, Kakegawa, Keiko, Takami, Kazuaki, Kikuchi, Fumiaki, Yamamoto, Takeshi, Nakamura, Minoru, Daini, Masaki, Murakami, Masataka, Ohashi, Tomohiro, Kasahara, Takahito, Wang, Junsi, Ikeda, Zenichi, Wada, Yasufumi, Puenner, Florian, Fujii, Takahiro, Inazuka, Masakazu, Sato, Sho, Suzaki, Tomohiko, Oak, Jeong-Ho, Takai, Yuichi, Kohara, Hiroshi, Kimoto, Kouya, Oki, Hideyuki, Mikami, Satoshi, Sasaki, Minoru, Tanaka, Yuta
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors
Kikuchi, Fumiaki, Ikeda, Zenichi, Kakegawa, Keiko, Nishikawa, Youichi, Sasaki, Shigekazu, Fukuda, Koichiro, Takami, Kazuaki, Banno, Yoshihiro, Nishikawa, Hitoaki, Taya, Naohiro, Nakahata, Takashi, Itono, Sachiko, Yashiro, Hiroaki, Tsuchimori, Kazue, Hiyoshi, Hideyuki, Sasaki, Masako, Tohyama, Kimio, Matsumiya, Kouta, Ishihara, Youko, Kawamoto, Tetsuji, Kamaura, Masahiro, Watanabe, Masanori, Kitazaki, Tomoyuki, Maekawa, Tsuyoshi, Sasaki, Minoru
Published in Bioorganic & medicinal chemistry (01.10.2023)
Published in Bioorganic & medicinal chemistry (01.10.2023)
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Strategy of optical path of daylight signal into tissues in cold-season turfgrasses using small, concave silica bodies
Yamanaka, Shigeru, Usami, Hisanao, Kakegawa, Keiko, Yoneda, Satoshi, Fukuda, Kenichi, Yoshino, Katsumi, Hayashida, Nobuaki, Murakami, Yasushi, Morikawa, Hideaki
Published in Scientific reports (06.07.2018)
Published in Scientific reports (06.07.2018)
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Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1‑(Imidazo[1,2‑a]pyridin-6-yl)pyridin-2(1H)‑one Derivatives
Igawa, Hideyuki, Takahashi, Masashi, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Kawata, Yayoi, Ashina, Shuntaro, Yamamoto, Syunsuke, Kundu, Mrinalkanti, Khamrai, Uttam, Hirabayashi, Hideki, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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HDAC6 억제제로서 유용한 2-이소인돌-1,3,4-옥사디아졸 유도체
SUGIYAMA HIDEYUKI, ITO MASAHIRO, YAMAMOTO TAKESHI, YOSHIKAWA MASATO, KASAHARA TAKAHITO, LI JINXING, WANG JUNSI, KAKEGAWA KEIKO
Year of Publication 31.05.2022
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Year of Publication 31.05.2022
Patent
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test
Igawa, Hideyuki, Takahashi, Masashi, Ikoma, Minoru, Kaku, Hiromi, Kakegawa, Keiko, Kina, Asato, Aida, Jumpei, Okuda, Shoki, Kawata, Yayoi, Noguchi, Toshihiro, Hotta, Natsu, Yamamoto, Syunsuke, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Bioorganic & medicinal chemistry (01.06.2016)
Published in Bioorganic & medicinal chemistry (01.06.2016)
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Journal Article
CONDENSED HETEROCYCLIC COMPOUND
IKEDA ZENICHI, SASAKI MINORU, NISHIKAWA YOICHI, KIKUCHI SHIRO, KAKEGAWA KEIKO
Year of Publication 13.12.2018
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Year of Publication 13.12.2018
Patent
Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1‑(Imidazo[1,2‑a]pyridin-6-yl)pyridin-2(1H)‑one Derivatives
Igawa, Hideyuki, Takahashi, Masashi, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Kawata, Yayoi, Ashina, Shuntaro, Yamamoto, Syunsuke, Kundu, Mrinalkanti, Khamrai, Uttam, Hirabayashi, Hideki, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Journal Article
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition
Igawa, Hideyuki, Takahashi, Masashi, Shirasaki, Mikio, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Okuda, Shoki, Kawata, Yayoi, Noguchi, Toshihiro, Yamamoto, Syunsuke, Fujioka, Yasushi, Kundu, Mrinalkanti, Khamrai, Uttam, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Bioorganic & medicinal chemistry (01.06.2016)
Published in Bioorganic & medicinal chemistry (01.06.2016)
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Journal Article
FUSED HETEROCYCLIC COMPOUND
IKEDA, Zenichi, KIKUCHI, Fumiaki, SASAKI, Minoru, NISHIKAWA, Yoichi, KAKEGAWA, Keiko
Year of Publication 06.10.2016
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Year of Publication 06.10.2016
Patent
FUSED HETEROCYCLIC COMPOUND
IKEDA ZENICHI, SASAKI MINORU, NISHIKAWA YOICHI, KIKUCHI FUMIAKI, KAKEGAWA KEIKO
Year of Publication 06.10.2016
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Year of Publication 06.10.2016
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HETEROCYCLIC COMPOUND
IKEDA ZENICHI, SASAKI MINORU, NISHIKAWA YOICHI, KIKUCHI FUMIAKI, KAKEGAWA KEIKO
Year of Publication 28.09.2016
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Year of Publication 28.09.2016
Patent
HETEROCYCLIC COMPOUND
IKEDA, Zenichi, TAKAMI, Kazuaki, PUENNER, Florian, SASAKI, Minoru, YAMAMOTO, Takeshi, NAKAMURA, Minoru, DAINI, Masaki, KIKUCHI, Fumiaki, WADA, Yasufumi, SETO, Masaki, MURAKAMI, Masataka, MIKAMI, Satoshi, KASAHARA, Takahito, WANG, Junsi, KAKEGAWA, Keiko, OHASHI, Tomohiro, TANAKA, Yuta
Year of Publication 04.02.2021
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Year of Publication 04.02.2021
Patent
HETEROCYCLIC COMPOUND
IKEDA, Zenichi, TAKAMI, Kazuaki, PUENNER, Florian, SASAKI, Minoru, YAMAMOTO, Takeshi, NAKAMURA, Minoru, DAINI, Masaki, KIKUCHI, Fumiaki, SETO, Masaki, MURAKAMI, Masataka, MIKAMI, Satoshi, KASAHARA, Takahito, KAKEGAWA, Keiko, OHASHI, Tomohiro, TANAKA, Yuta
Year of Publication 04.02.2021
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Year of Publication 04.02.2021
Patent
Design, synthesis, and structure–activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors
Yamashita, Tohru, Kamata, Makoto, Endo, Satoshi, Yamamoto, Mitsuo, Kakegawa, Keiko, Watanabe, Hiroyuki, Miwa, Katsuhiko, Yamano, Toru, Funata, Masaaki, Sakamoto, Jyun-ichi, Tani, Akiyoshi, Mol, Clifford D., Zou, Hua, Dougan, Douglas R., Sang, BiChing, Snell, Gyorgy, Fukatsu, Kohji
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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HETEROCYCLIC COMPOUND
KUBO, Osamu, MIYAZAKI, Tohru, SASAKI, Shinobu, SUGIYAMA, Hideyuki, KOJIMA, Takuto, SASAKI, Minoru, HOMMA, Misaki, ARIKAWA, Yasuyoshi, YAMAMOTO, Takeshi, YONEMORI, Jinichi, ASANO, Yasutomi, KIKUCHI, Fumiaki, IMAEDA, Yasuhiro, SATO, Ayumu, KAMITANI, Hirotaka, YOSHIKAWA, Masato, OKAWA, Tomohiro, KOKUBO, Hironori, MAEZAKI, Hironobu, TOITA, Akinori, ITO, Masahiro, KAKEGAWA, Keiko
Year of Publication 06.08.2020
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Year of Publication 06.08.2020
Patent
HETEROCYCLIC COMPOUND
MORISHITA, Nao, IKEDA, Zenichi, TAKAMI, Kazuaki, PUENNER, Florian, SASAKI, Minoru, YAMAMOTO, Takeshi, NAKAMURA, Minoru, DAINI, Masaki, KIKUCHI, Fumiaki, SETO, Masaki, MURAKAMI, Masataka, MIKAMI, Satoshi, KASAHARA, Takahito, KAKEGAWA, Keiko, OHASHI, Tomohiro, TANAKA, Yuta
Year of Publication 08.08.2019
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Year of Publication 08.08.2019
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헤테로시클릭 화합물
NAKAHATA TAKASHI, SHIOKAWA ZENYU, TAKAGI TERUFUMI, SABAT MARK, WANG XIAOLUN, KAKEGAWA KEIKO, KOMANDLA MALLAREDDY, TANIS PAUL, NISHIKAWA YOICHI, TYHONAS JOHN, SCORAH NICHOLAS, TANAKA YUTA, TAKAHAGI HIROKI, OKAWA TOMOHIRO, MATSUNAGA NOBUYUKI, VU PHONG H, YUKAWA TAKAFUMI, TAKAHASHI MASASHI, MIURA JOANNE, TERAO YOSHITO, OKAMOTO REI, KWOK LILY, SHIRAI JUNYA, MIYAMOTO YASUFUMI, SHIBUYA AKITO, WANG HAIXIA, YOSHIKAWA TAKESHI
Year of Publication 13.03.2020
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Year of Publication 13.03.2020
Patent
CONDENSED HETEROCYCLIC COMPOUND
TAKAMI, KAZUAKI, KAMAURA, MASAHIRO, SASAKI, MINORU, FUKUDA, KOICHIRO, BANNO, YOSHIHIRO, KIKUCHI, FUMIAKI, IKEDA, ZENICHI, NISHIKAWA, YOICHI, KAKEGAWA, KEIKO, SASAKI, SHIGEKAZU
Year of Publication 30.06.2016
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Year of Publication 30.06.2016
Patent