Synthesis and structure–activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study
Kuramochi, Takahiro, Kakefuda, Akio, Sato, Ippei, Tsukamoto, Issei, Taguchi, Taku, Sakamoto, Shuichi
Published in Bioorganic & medicinal chemistry (01.02.2005)
Published in Bioorganic & medicinal chemistry (01.02.2005)
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Synthesis and structure–activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure
Kuramochi, Takahiro, Kakefuda, Akio, Yamada, Hiroyoshi, Ogiyama, Takashi, Taguchi, Taku, Sakamoto, Shuichi
Published in Bioorganic & medicinal chemistry (01.02.2005)
Published in Bioorganic & medicinal chemistry (01.02.2005)
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Journal Article
Synthesis and structure–activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium–calcium exchanger
Kuramochi, Takahiro, Kakefuda, Akio, Yamada, Hiroyoshi, Sato, Ippei, Taguchi, Taku, Sakamoto, Shuichi
Published in Bioorganic & medicinal chemistry (01.10.2004)
Published in Bioorganic & medicinal chemistry (01.10.2004)
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Journal Article
Discovery of N-(3-{4-[(3-Fluorobenzyl)oxy]phenoxy}propyl)-2-pyridin-4-ylacetamide as a Potent and Selective Reverse NCX Inhibitor
Kuramochi, Takahiro, Kakefuda, Akio, Yamada, Hiroyoshi, Ogiyama, Takashi, Taguchi, Taku, Sakamoto, Shuichi
Published in Chemical & Pharmaceutical Bulletin (01.08.2005)
Published in Chemical & Pharmaceutical Bulletin (01.08.2005)
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Synthesis and Pharmacological Evaluation of 2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinoline Derivatives as Specific Bradycardic Agents
Kakefuda, Akio, Watanabe, Toshihiro, Taguchi, Yasuko, Masuda, Noriyuki, Tanaka, Akihiro, Yanagisawa, Isao
Published in Chemical & Pharmaceutical Bulletin (2003)
Published in Chemical & Pharmaceutical Bulletin (2003)
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Synthesis and Biological Evaluation of Phenylacetyl Derivatives Having Low Central Nervous System Permeability as Potent and Selective M2 Muscarinic Receptor Antagonists
WATANABE, Toshihiro, KAKEFUDA, Akio, TANAKA, Akihiro, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBATA, Hiroshi, YAMAGIWA, Yoko, YANAGISAWA, Isao
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor
Watanabe, Kazushi, Kakefuda, Akio, Yasuda, Minoru, Enjo, Kentaro, Kikuchi, Aya, Furutani, Takashi, Naritomi, Yoichi, Otsuka, Yukio, Okada, Minoru, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (01.09.2013)
Published in Bioorganic & medicinal chemistry (01.09.2013)
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Journal Article
Synthesis of Novel Succinamide Derivatives Having the 5, 11-Dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. I
WATANABE, Toshihiro, KINOYAMA, Isao, KAKEFUDA, Akio, OKAZAKI, Toshio, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBATA, Hiroshi, YANAGISAWA, Isao
Published in Chemical & pharmaceutical bulletin (1997)
Published in Chemical & pharmaceutical bulletin (1997)
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Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}pro p an-2-ol: A novel, potent and selective type 5 17I2-hydroxysteroid dehydrogenase inhibitor
Watanabe, Kazushi, Kakefuda, Akio, Yasuda, Minoru, Enjo, Kentaro, Kikuchi, Aya, Furutani, Takashi, Naritomi, Yoichi, Otsuka, Yukio, Okada, Minoru, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (01.09.2013)
Published in Bioorganic & medicinal chemistry (01.09.2013)
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Journal Article
Synthesis of Novel Succinamide Derivatives Having a 5, 11-Dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. II
WATANABE, Toshihiro, KAKEFUDA, Akio, KINOYAMA, Isao, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBATA, Hiroshi, YANAGISAWA, Isao
Published in Chemical & pharmaceutical bulletin (1997)
Published in Chemical & pharmaceutical bulletin (1997)
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Journal Article
Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. II. Syntheses and NK2 Receptor-Antagonistic Activities of N-(2-Aryl-4-(spiro-substituted piperidin-1'-yl)butyl)carboxamides
KUBOTA, Hirokazu, KAKEFUDA, Akio, NAGAOKA, Hitoshi, YAMAMOTO, Osamu, IKEDA, Ken, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition
Freeman, David B., Holubec, Alexandra A., Weiss, Matthew W., Dixon, Julie A., Kakefuda, Akio, Ohtsuka, Masami, Inoue, Munenori, Vaswani, Rishi G., Ohki, Hidenori, Doan, Brian D., Reisman, Sarah E., Stoltz, Brian M., Day, Joshua J., Tao, Ran N., Dieterich, Noah A., Wood, John L.
Published in Tetrahedron (14.08.2010)
Published in Tetrahedron (14.08.2010)
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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. III. Synthesis of (.+-.)-N-12-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1-yl)butyll-N-methylbenzamides and Evaluation of NK1-NK2 Dual Antagonistic Activities
KUBOTA, Hirokazu, KAKEFUDA, Akio, OKAMOTO, Yoshinori, FUJII, Masahiro, YAMAMOTO, Osamu, YAMAGIWA, Yoko, ORITA, Masaya, IKEDA, Ken, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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CRYSTALS OF ANDROGEN RECEPTOR ANTAGONIST COMPOUND
KAKEFUDA, AKIO, NAKAMURA, TAKASHI, YAMAZAKI, KOUJI, YAMASHITA, HIROYUKI, HIRAKURA, YUTAKA, OKAMOTO, TAKUMI
Year of Publication 25.04.2013
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Year of Publication 25.04.2013
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Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition: 2009 Tetrahedron Prize for Creativity in Organic Chemistry: Adventures in Organic Synthesis: Steven V. Ley
FREEMAN, David B, HOLUBEC, Alexandra A, REISMAN, Sarah E, STOLTZ, Brian M, DAY, Joshua J, TAO, Ran N, DIETERICH, Noah A, WOOD, John L, WEISS, Matthew W, DIXON, Julie A, KAKEFUDA, Akio, OHTSUKA, Masami, INOUE, Munenori, VASWANI, Rishi G, OHKI, Hidenori, DOAN, Brian D
Published in Tetrahedron (2010)
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Published in Tetrahedron (2010)
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Synthesis and Pharmacological Evaluation of 5-(4-Biphenyl)-3-methyl-4-phenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human Vasopressin V1A Receptor
Kakefuda, Akio, Suzuki, Takeshi, Tobe, Takahiko, Tsukada, Junko, Tahara, Atsuo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Discovery of 4,5-diphenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human V1A receptor
KAKEFUDA, Akio, SUZUKI, Takeshi, TOBE, Takahiko, TAHARA, Atsuo, SAKAMOTO, Shuichi, TSUKAMOTO, Shin-Ichi
Published in Bioorganic & medicinal chemistry (01.06.2002)
Published in Bioorganic & medicinal chemistry (01.06.2002)
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Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor
Kuramochi, Takahiro, Kakefuda, Akio, Yamada, Hiroyoshi, Tsukamoto, Issei, Taguchi, Taku, Sakamoto, Shuichi
Published in Bioorganic & medicinal chemistry (02.06.2005)
Published in Bioorganic & medicinal chemistry (02.06.2005)
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ANTAGONIST FOR MUTATED ANDROGEN RECEPTOR
FURUTANI TAKASHI, TANIGUCHI NOBUAKI, SUGANE TAKASHI, YAMADA TOMOHIRO, WATANABE KAZUSHI, HIRANO MASAAKI, KONAGAI SATOSHI, TAKEDA MASAYOSHI, KONDOH YUTAKA, KAKEFUDA AKIO, IDEYAMA YUKITAKA, KUROMITSU SADAO
Year of Publication 23.12.2013
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Year of Publication 23.12.2013
Patent
INDOLE COMPOUND
KAKEFUDA, AKIO, WATANABE, KAZUSHI, KONDOH, YUTAKA, AZAMI, HIDENORI, YASUDA, MINORU, ABE, TOMOAKI, KAMIKAWA, AKIO
Year of Publication 10.09.2010
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Year of Publication 10.09.2010
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