Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs
Duan, Jian-Xin, Jiao, Hailong, Kaizerman, Jacob, Stanton, Timothy, Evans, James W, Lan, Leslie, Lorente, Gustavo, Banica, Monica, Jung, Don, Wang, Jinwei, Ma, Huaiyu, Li, Xiaoming, Yang, Zhijian, Hoffman, Robert M, Ammons, W. Steve, Hart, Charles P, Matteucci, Mark
Published in Journal of medicinal chemistry (24.04.2008)
Published in Journal of medicinal chemistry (24.04.2008)
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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives
Bürli, Roland W, McMinn, Dustin, Kaizerman, Jacob A, Hu, Wenhao, Ge, Yigong, Pack, Quinn, Jiang, Vernon, Gross, Matthew, Garcia, Martin, Tanaka, Richard, Moser, Heinz E
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
Kaizerman, Jacob A., Aaron, Wade, An, Songzhu, Austin, Richard, Brown, Matt, Chong, Angela, Huang, Tom, Hungate, Randall, Jiang, Ben, Johnson, Michael G., Lee, Gary, Lucas, Brian S., Orf, Jessica, Rong, Minqing, Toteva, Maria M., Wickramasinghe, Dineli, Xu, Guifen, Ye, Qiuping, Zhong, Wendy, McMinn, Dustin L.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit
Brown, Matthew L., Aaron, Wade, Austin, Richard J., Chong, Angela, Huang, Tom, Jiang, Ben, Kaizerman, Jacob A., Lee, Gary, Lucas, Brian S., McMinn, Dustin L., Orf, Jessica, Rong, Minqing, Toteva, Maria M., Xu, Guifen, Ye, Qiuping, Zhong, Wendy, DeGraffenreid, Michael R., Wickramasinghe, Dineli, Powers, Jay P., Hungate, Randall, Johnson, Michael G.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists
Lucas, Brian S., Aaron, Wade, An, Songzhu, Austin, Richard J., Brown, Matthew, Chan, Hon, Chong, Angela, Hungate, Randall, Huang, Tom, Jiang, Ben, Johnson, Michael G., Kaizerman, Jacob A., Lee, Gary, McMinn, Dustin L., Orf, Jessica, Powers, Jay P., Rong, Minqing, Toteva, Maria M., Uyeda, Craig, Wickramasinghe, Dineli, Xu, Guifen, Ye, Qiuping, Zhong, Wendy
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives
Bürli, Roland W, Jones, Peter, McMinn, Dustin, Le, Quan, Duan, Jian-Xin, Kaizerman, Jacob A, Difuntorum, Stacey, Moser, Heinz E
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters
DeGraffenreid, Michael R, Bennett, Sarah, Caille, Sebastien, Gonzalez-Lopez de Turiso, Felix, Hungate, Randall W, Julian, Lisa D, Kaizerman, Jacob A, McMinn, Dustin L, Rew, Yosup, Sun, Daqing, Yan, Xuelei, Powers, Jay P
Published in Journal of organic chemistry (14.09.2007)
Published in Journal of organic chemistry (14.09.2007)
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Journal Article
DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus
Hu, Wenhao, Bürli, Roland W, Kaizerman, Jacob A, Johnson, Kirk W, Gross, Matthew I, Iwamoto, Mari, Jones, Peter, Lofland, Denene, Difuntorum, Stacey, Chen, Hsiu, Bozdogan, Bülent, Appelbaum, Peter C, Moser, Heinz E
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Journal Article
DNA Binding Ligands with Excellent Antibiotic Potency Against Drug-Resistant Gram-Positive Bacteria
Bürli, Roland W., Ge, Yigong, White, Sarah, Baird, Eldon E., Touami, Sofia M., Taylor, Matthew, Kaizerman, Jacob A., Moser, Heinz E.
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Journal Article
DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology
Kaizerman, Jacob A, Gross, Matthew I, Ge, Yigong, White, Sarah, Hu, Wenhao, Duan, Jian-Xin, Baird, Eldon E, Johnson, Kirk W, Tanaka, Richard D, Moser, Heinz E, Bürli, Roland W
Published in Journal of medicinal chemistry (28.08.2003)
Published in Journal of medicinal chemistry (28.08.2003)
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DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids
BÜRLI, Roland W, KAIZERMAN, Jacob A, TOUAMI, Sofia, GROSS, Matthew, JIANG, Vernon, YIGONG GE, MOSER, Heinz E, DUAN, Jian-Xin, JONES, Peter, JOHNSON, Kirk W, IWAMOTO, Mari, TRUONG, Kiet, WENHAO HU, STANTON, Timothy, CHEN, Alfred
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Journal Article
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives
BÜRLI, Roland W, MCMINN, Dustin, MOSER, Heinz E, KAIZERMAN, Jacob A, WENHAO HU, YIGONG GE, PACK, Quinn, JIANG, Vernon, GROSS, Matthew, GARCIA, Martin, TANAKA, Richard
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
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Journal Article
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives
BÜRLI, Roland W, JONES, Peter, MCMINN, Dustin, QUAN LE, DUAN, Jian-Xin, KAIZERMAN, Jacob A, DIFUNTORUM, Stacey, MOSER, Heinz E
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
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Journal Article
Abstract 2351: CDK4/FLT3 dual inhibitors as potential therapeutics for acute myeloid leukemia
Li, Zhihong, Dai, Kang, Keegan, Kathleen, Ma, Ji, Ragains, Mark, Kaizerman, Jacob, McMinn, Dustin, Fu, Jiasheng, Fisher, Benjamin, Gribble, Michael, McGee, Lawrence R., Eksterowicz, John, Li, Cong, Liang, Lingming, Weidner, Margaret, Huard, Justin, Cho, Robert, Carlson, Timothy, Alba, Grace M., Hollenback, David, Hill, John, Beaupre, Darrin, Kamb, Alexander, Wickramasinghe, Dineli, Medina, Julio C.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors
McMinn, Dustin L., Rew, Yosup, Sudom, Athena, Caille, Seb, DeGraffenreid, Michael, He, Xiao, Hungate, Randall, Jiang, Ben, Jaen, Juan, Julian, Lisa D., Kaizerman, Jacob, Novak, Perry, Sun, Daqing, Tu, Hua, Ursu, Stefania, Walker, Nigel P.C., Yan, Xuelei, Ye, Qiuping, Wang, Zhulun, Powers, Jay P.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors
Sun, Daqing, Wang, Zhulun, Caille, Seb, DeGraffenreid, Michael, Gonzalez-Lopez de Turiso, Felix, Hungate, Randall, Jaen, Juan C., Jiang, Ben, Julian, Lisa D., Kelly, Ron, McMinn, Dustin L., Kaizerman, Jacob, Rew, Yosup, Sudom, Athena, Tu, Hua, Ursu, Stefania, Walker, Nigel, Willcockson, Maren, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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