Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
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Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2011)
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Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice
Camporez, João Paulo G, Jornayvaz, François R, Petersen, Max C, Pesta, Dominik, Guigni, Blas A, Serr, Julie, Zhang, Dongyan, Kahn, Mario, Samuel, Varman T, Jurczak, Michael J, Shulman, Gerald I
Published in Endocrinology (Philadelphia) (01.09.2013)
Published in Endocrinology (Philadelphia) (01.09.2013)
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Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
Bhat, Neha, Narayanan, Anand, Fathzadeh, Mohsen, Kahn, Mario, Zhang, Dongyan, Goedeke, Leigh, Neogi, Arpita, Cardone, Rebecca L, Kibbey, Richard G, Fernandez-Hernando, Carlos, Ginsberg, Henry N, Jain, Dhanpat, Shulman, Gerald I, Mani, Arya
Published in The Journal of clinical investigation (01.02.2022)
Published in The Journal of clinical investigation (01.02.2022)
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Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance
Camporez, João Paulo G, Jornayvaz, François R, Lee, Hui-Young, Kanda, Shoichi, Guigni, Blas A, Kahn, Mario, Samuel, Varman T, Carvalho, Carla R.O, Petersen, Kitt Falk, Jurczak, Michael J, Shulman, Gerald I
Published in Endocrinology (Philadelphia) (01.03.2013)
Published in Endocrinology (Philadelphia) (01.03.2013)
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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway
Xu, Weiwei, Zhang, Dongyan, Ma, Yumin, Gaspar, Rafael C., Kahn, Mario, Nasiri, Ali, Murray, Sue, Samuel, Varman T., Shulman, Gerald I.
Published in Cell reports (Cambridge) (22.10.2024)
Published in Cell reports (Cambridge) (22.10.2024)
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CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
Cantley, Jennifer L., Yoshimura, Toru, Camporez, Joao Paulo G., Zhang, Dongyan, Jornayvaz, Francois R., Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Jurczak, Michael J., Kahn, Mario, Guigni, Bias A., Serr, Julie, Hankin, Joseph, Murphy, Robert C., Cline, Gary W., Bhanot, Sanjay, Manchem, Vara Prasad, Brown, J. Mark, Samuel, Varman T., Shulman, Gerald I.
Published in Proceedings of the National Academy of Sciences - PNAS (29.01.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (29.01.2013)
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Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice
Abulizi, Abudukadier, Vatner, Daniel F., Ye, Zhang, Wang, Yongliang, Camporez, Joao-Paulo, Zhang, Dongyan, Kahn, Mario, Lyu, Kun, Sirwi, Alaa, Cline, Gary W., Hussain, M. Mahmood, Aspichueta, Patricia, Samuel, Varman T., Shulman, Gerald I.
Published in Journal of lipid research (01.12.2020)
Published in Journal of lipid research (01.12.2020)
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Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
Jurczak, Michael J., Lee, Ann-Hwee, Jornayvaz, Francois R., Lee, Hui-Young, Birkenfeld, Andreas L., Guigni, Blas A., Kahn, Mario, Samuel, Varman T., Glimcher, Laurie H., Shulman, Gerald I.
Published in The Journal of biological chemistry (20.01.2012)
Published in The Journal of biological chemistry (20.01.2012)
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Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
KUMASHIRO, Naoki, BEDDOW, Sara A, KAHN, Mario, PERLER, Bryce K, PUCHOWICZ, Michelle A, VARA PRASAD MANCHEM, BHANOT, Sanjay, STILL, Christopher D, GERHARD, Glenn S, PETERSEN, Kitt Falk, CLINE, Gary W, SHULMAN, Gerald I, VATNER, Daniel F, SAMUEL, Varman T, MAJUMDAR, Sachin K, CANTLEY, Jennifer L, GUEBRE-EGZIABHER, Fitsum, FAT, Ioana, GUIGNI, Blas, JURCZAK, Michael J, BIRKENFELD, Andreas L
Published in Diabetes (New York, N.Y.) (01.07.2013)
Published in Diabetes (New York, N.Y.) (01.07.2013)
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Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
Galbo, Thomas, Perry, Rachel J., Jurczak, Michael J., Camporez, João-Paulo G., Alves, Tiago C., Kahn, Mario, Guigni, Blas A., Serr, Julle, Zhang, Dongyan, Bhanot, Sanjay, Samuel, Varman T., Shulman, Gerald I.
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
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Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance
Choi, Cheol Soo, Savage, David B., Kulkarni, Ameya, Yu, Xing Xian, Liu, Zhen-Xiang, Morino, Katsutaro, Kim, Sheene, Distefano, Alberto, Samuel, Varman T., Neschen, Susanne, Zhang, Dongyan, Wang, Amy, Zhang, Xian-Man, Kahn, Mario, Cline, Gary W., Pandey, Sanjay K., Geisler, John G., Bhanot, Sanjay, Monia, Brett P., Shulman, Gerald I.
Published in The Journal of biological chemistry (03.08.2007)
Published in The Journal of biological chemistry (03.08.2007)
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Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
ESTALL, Jennifer L, KAHN, Mario, COOPER, Marcus P, FISHER, Ffolliott Martin, WU, Michele K, LAZNIK, Dina, LISHU QU, COHEN, David E, SHULMAN, Gerald I, SPIEGELMAN, Bruce M
Published in Diabetes (New York, N.Y.) (01.07.2009)
Published in Diabetes (New York, N.Y.) (01.07.2009)
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Role of patatin‐like phospholipase domain‐containing 3 on lipid‐induced hepatic steatosis and insulin resistance in rats
Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L., Majumdar, Sachin K., Guebre‐Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F., Fat, Ioana, Kahn, Mario, Erion, Derek M., Zhang, Xian‐Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S., Petersen, Kitt F., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.
Published in Hepatology (Baltimore, Md.) (01.05.2013)
Published in Hepatology (Baltimore, Md.) (01.05.2013)
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The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats
Erion, Derek M, Popov, Violetta, Hsiao, Jennifer J, Vatner, Daniel, Mitchell, Kisha, Yonemitsu, Shin, Nagai, Yoshio, Kahn, Mario, Gillum, Matthew P, Dong, Jianying, Murray, Susan F, Manchem, Vara Prasad, Bhanot, Sanjay, Cline, Gary W, Shulman, Gerald I, Samuel, Varman T
Published in Endocrinology (Philadelphia) (01.01.2013)
Published in Endocrinology (Philadelphia) (01.01.2013)
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Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
Choi, Cheol Soo, Fillmore, Jonathan J, Kim, Jason K, Liu, Zhen-Xiang, Kim, Sheene, Collier, Emily F, Kulkarni, Ameya, Distefano, Alberto, Hwang, Yu-Jin, Kahn, Mario, Chen, Yan, Yu, Chunli, Moore, Irene K, Reznick, Richard M, Higashimori, Takamasa, Shulman, Gerald I
Published in The Journal of clinical investigation (01.07.2007)
Published in The Journal of clinical investigation (01.07.2007)
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Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein
Erion, Derek M., Ignatova, Irena D., Yonemitsu, Shin, Nagai, Yoshio, Chatterjee, Paula, Weismann, Dirk, Hsiao, Jennifer J., Zhang, Dongyan, Iwasaki, Takanori, Stark, Romana, Flannery, Clare, Kahn, Mario, Carmean, Christopher M., Yu, Xing Xian, Murray, Susan F., Bhanot, Sanjay, Monia, Brett P., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.
Published in Cell metabolism (01.12.2009)
Published in Cell metabolism (01.12.2009)
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Ordered equilibrium structures of soft particles in thin layers
Kahn, Mario, Weis, Jean-Jacques, Kahl, Gerhard
Published in The Journal of chemical physics (14.12.2010)
Published in The Journal of chemical physics (14.12.2010)
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Journal Article
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
Brown, Whitney H., Gillum, Matthew P., Lee, Hui-Young, Camporez, Joao Paulo G., Zhang, Xian-man, Jeong, Jin Kwon, Alves, Tiago C., Erion, Derek M., Guigni, Blas A., Kahn, Mario, Samuel, Varman T., Cravatt, Benjamin F., Diano, Sabrina, Shulman, Gerald I.
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2012)
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Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis
Edmunds, Lia R., Huckestein, Brydie R., Kahn, Mario, Zhang, Dongyan, Chu, Yanxia, Zhang, Yingze, Wendell, Stacy G., Shulman, Gerald I., Jurczak, Michael J.
Published in Physiological reports (01.11.2019)
Published in Physiological reports (01.11.2019)
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