PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
Baki, Lia, Shioi, Junichi, Wen, Paul, Shao, Zhiping, Schwarzman, Alexander, Gama-Sosa, Miguel, Neve, Rachael, Robakis, Nikolaos K
Published in The EMBO journal (07.07.2004)
Published in The EMBO journal (07.07.2004)
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Presenilin-1 Binds Cytoplasmic Epithelial Cadherin, Inhibits Cadherin/p120 Association, and Regulates Stability and Function of the Cadherin/Catenin Adhesion Complex
Baki, Lia, Marambaud, Philippe, Efthimiopoulos, Spiros, Georgakopoulos, Anastasios, Wen, Paul, Cui, Wen, Shioi, Junichi, Koo, Eduard, Ozawa, Masayuki, Friedrich, Victor L., Robakis, Nikolaos K.
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2001)
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Journal Article
Overexpression of Wild Type But Not an FAD Mutant Presenilin-1 Promotes Neurogenesis in the Hippocampus of Adult Mice
Wen, Paul H., Shao, Xiang, Shao, Zhiping, Hof, Patrick R., Wisniewski, Thomas, Kelley, Kevin, Friedrich, Victor L., Ho, Lap, Pasinetti, Giulio M., Shioi, Junichi, Robakis, Nikolaos K., Elder, Gregory A.
Published in Neurobiology of disease (01.06.2002)
Published in Neurobiology of disease (01.06.2002)
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Journal Article
Appican, the Proteoglycan Form of the Amyloid Precursor Protein, Contains Chondroitin Sulfate E in the Repeating Disaccharide Region and 4-O-Sulfated Galactose in the Linkage Region
Tsuchida, Kazunori, Shioi, Junichi, Yamada, Shuhei, Boghosian, Garen, Wu, Anfan, Cai, Hongying, Sugahara, Kazuyuki, Robakis, Nikolaos K.
Published in The Journal of biological chemistry (05.10.2001)
Published in The Journal of biological chemistry (05.10.2001)
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Journal Article
Enrichment of Presenilin 1 Peptides in Neuronal Large Dense‐Core and Somatodendritic Clathrin‐Coated Vesicles
Efthimiopoulos, Spiros, Floor, Erik, Georgakopoulos, Anastasios, Shioi, Junichi, Cui, Wen, Yasothornsrikul, Sukkid, Hook, Vivian Y. H., Wisniewski, Thomas, Buee, Luc, Robakis, Nikolaos K.
Published in Journal of neurochemistry (01.12.1998)
Published in Journal of neurochemistry (01.12.1998)
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Journal Article
Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling
Xu, Jindong, Xilouri, Maria, Bruban, Julien, Shioi, Junichi, Shao, Zhiping, Papazoglou, Ioannis, Vekrellis, Kostas, Robakis, Nikolaos K
Published in Neurobiology of aging (01.12.2011)
Published in Neurobiology of aging (01.12.2011)
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Journal Article
Appican Expression Induces Morphological Changes in C6 Glioma Cells and Promotes Adhesion of Neural Cells to the Extracellular Matrix
Wu, Anfan, Pangalos, Menelas N, Efthimiopoulos, Spiros, Shioi, Junichi, Robakis, Nikolaos K
Published in The Journal of neuroscience (01.07.1997)
Published in The Journal of neuroscience (01.07.1997)
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Journal Article
A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations
Marambaud, Philippe, Wen, Paul H, Dutt, Anindita, Shioi, Junichi, Takashima, Akihiko, Siman, Robert, Robakis, Nikolaos K
Published in Cell (05.09.2003)
Published in Cell (05.09.2003)
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Journal Article
Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor
Litterst, Claudia, Georgakopoulos, Anastasios, Shioi, Junichi, Ghersi, Enrico, Wisniewski, Thomas, Wang, Rong, Ludwig, Andreas, Robakis, Nikolaos K.
Published in The Journal of biological chemistry (01.06.2007)
Published in The Journal of biological chemistry (01.06.2007)
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Journal Article
The Alzheimer Amyloid Precursor Proteoglycan (Appican) Is Present in Brain and Is Produced by Astrocytes but Not by Neurons in Primary Neural Cultures
Shioi, Junichi, Pangalos, Menelas N., Ripellino, James A., Vassilacopoulou, Dido, Mytilineou, Catherine, Margolis, Richard U., Robakis, Nikolaos K.
Published in The Journal of biological chemistry (19.05.1995)
Published in The Journal of biological chemistry (19.05.1995)
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Journal Article
Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
Barthet, Gael, Shioi, Junichi, Shao, Zhiping, Ren, Yimin, Georgakopoulos, Anastasios, Robakis, Nikolaos K
Published in The FASEB journal (01.09.2011)
Published in The FASEB journal (01.09.2011)
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Journal Article
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors
Barthet, Gael, Dunys, Julie, Shao, Zhiping, Xuan, Zhao, Ren, Yimin, Xu, Jindong, Arbez, Nicolas, Mauger, Gweltas, Bruban, Julien, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K
Published in Neurobiology of aging (01.02.2013)
Published in Neurobiology of aging (01.02.2013)
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Journal Article
A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
Marambaud, Philippe, Shioi, Junichi, Serban, Geo, Georgakopoulos, Anastasios, Sarner, Shula, Nagy, Vanja, Baki, Lia, Wen, Paul, Efthimiopoulos, Spiros, Shao, Zhiping, Wisniewski, Thomas, Robakis, Nikolaos K.
Published in The EMBO journal (15.04.2002)
Published in The EMBO journal (15.04.2002)
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Journal Article
Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling
Baki, Lia, Neve, Rachael L, Shao, Zhiping, Shioi, Junichi, Georgakopoulos, Anastasios, Robakis, Nikolaos K
Published in The Journal of neuroscience (09.01.2008)
Published in The Journal of neuroscience (09.01.2008)
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Journal Article
Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms
Bruban, Julien, Voloudakis, Georgios, Huang, Qian, Kajiwara, Yuji, Al Rahim, Md, Yoon, Yonejung, Shioi, Junichi, Gama Sosa, Miguel A, Shao, Zhiping, Georgakopoulos, Anastasios, Robakis, Nikolaos K
Published in The FASEB journal (01.09.2015)
Published in The FASEB journal (01.09.2015)
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Journal Article
Presenilin-1 expression in Pick's disease
GIANNAKOPOULOS, P, KÖVARI, E, BUEE, L, SHIOI, J, HOF, P. R, ROBAKIS, N. K, BOURAS, C
Published in Acta neuropathologica (01.11.1999)
Published in Acta neuropathologica (01.11.1999)
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Conference Proceeding
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Presenilin-1/γ-Secretase Controls Glutamate Release, Tyrosine Phosphorylation, and Surface Expression of N-Methyl-d-aspartate Receptor (NMDAR) Subunit GluN2B
Xuan, Zhao, Barthet, Gael, Shioi, Junichi, Xu, Jindong, Georgakopoulos, Anastasios, Bruban, Julien, Robakis, Nikolaos K.
Published in The Journal of biological chemistry (18.10.2013)
Published in The Journal of biological chemistry (18.10.2013)
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