Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Ringel, Alison E., Drijvers, Jefte M., Baker, Gregory J., Catozzi, Alessia, García-Cañaveras, Juan C., Gassaway, Brandon M., Miller, Brian C., Juneja, Vikram R., Nguyen, Thao H., Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T., LaFleur, Martin W., Trombley, Justin D., Jacobson, Connor A., Maliga, Zoltan, Gygi, Steven P., Sorger, Peter K., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.
Published in Cell (23.12.2020)
Published in Cell (23.12.2020)
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Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth
Kleffel, Sonja, Posch, Christian, Barthel, Steven R., Mueller, Hansgeorg, Schlapbach, Christoph, Guenova, Emmanuella, Elco, Christopher P., Lee, Nayoung, Juneja, Vikram R., Zhan, Qian, Lian, Christine G., Thomi, Rahel, Hoetzenecker, Wolfram, Cozzio, Antonio, Dummer, Reinhard, Mihm, Martin C., Flaherty, Keith T., Frank, Markus H., Murphy, George F., Sharpe, Arlene H., Kupper, Thomas S., Schatton, Tobias
Published in Cell (10.09.2015)
Published in Cell (10.09.2015)
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Journal Article
Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo
Driskell, Ryan R., Juneja, Vikram R., Connelly, John T., Kretzschmar, Kai, Tan, David W.-M., Watt, Fiona M.
Published in Journal of investigative dermatology (01.04.2012)
Published in Journal of investigative dermatology (01.04.2012)
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Journal Article
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity
Juneja, Vikram R, McGuire, Kathleen A, Manguso, Robert T, LaFleur, Martin W, Collins, Natalie, Haining, W Nicholas, Freeman, Gordon J, Sharpe, Arlene H
Published in The Journal of experimental medicine (03.04.2017)
Published in The Journal of experimental medicine (03.04.2017)
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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
Manguso, Robert T, Pope, Hans W, Zimmer, Margaret D, Brown, Flavian D, Yates, Kathleen B, Miller, Brian C, Collins, Natalie B, Bi, Kevin, LaFleur, Martin W, Juneja, Vikram R, Weiss, Sarah A, Lo, Jennifer, Fisher, David E, Miao, Diana, Van Allen, Eliezer, Root, David E, Sharpe, Arlene H, Doench, John G, Haining, W Nicholas
Published in Nature (London) (27.07.2017)
Published in Nature (London) (27.07.2017)
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Journal Article
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
Tan, Catherine L, Kuchroo, Juhi R, Sage, Peter T, Liang, Dan, Francisco, Loise M, Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L, Juneja, Vikram R, Lee, Sun Jung, Lovitch, Scott B, Lian, Christine, Murphy, George F, Blazar, Bruce R, Vignali, Dario A A, Freeman, Gordon J, Sharpe, Arlene H
Published in The Journal of experimental medicine (04.01.2021)
Published in The Journal of experimental medicine (04.01.2021)
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Journal Article
Suppression by T FR cells leads to durable and selective inhibition of B cell effector function
Sage, Peter T, Ron-Harel, Noga, Juneja, Vikram R, Sen, Debattama R, Maleri, Seth, Sungnak, Waradon, Kuchroo, Vijay K, Haining, W Nicholas, Chevrier, Nicolas, Haigis, Marcia, Sharpe, Arlene H
Published in Nature immunology (01.12.2016)
Published in Nature immunology (01.12.2016)
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Journal Article
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
Paterson, Alison M, Lovitch, Scott B, Sage, Peter T, Juneja, Vikram R, Lee, Youjin, Trombley, Justin D, Arancibia-Cárcamo, Carolina V, Sobel, Raymond A, Rudensky, Alexander Y, Kuchroo, Vijay K, Freeman, Gordon J, Sharpe, Arlene H
Published in The Journal of experimental medicine (21.09.2015)
Published in The Journal of experimental medicine (21.09.2015)
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Journal Article
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8 + T Cells
Drijvers, Jefte M, Gillis, Jacob E, Muijlwijk, Tara, Nguyen, Thao H, Gaudiano, Emily F, Harris, Isaac S, LaFleur, Martin W, Ringel, Alison E, Yao, Cong-Hui, Kurmi, Kiran, Juneja, Vikram R, Trombley, Justin D, Haigis, Marcia C, Sharpe, Arlene H
Published in Cancer immunology research (01.02.2021)
Published in Cancer immunology research (01.02.2021)
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Journal Article
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade
Chen, Ivy X., Newcomer, Kathleen, Pauken, Kristen E., Juneja, Vikram R., Naxerova, Kamila, Wu, Michelle W., Pinter, Matthias, Sen, Debattama R., Singer, Meromit, Sharpe, Arlene H., Jain, Rakesh K.
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2020)
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Journal Article
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
Lo, Jennifer A, Kawakubo, Masayoshi, Juneja, Vikram R, Su, Mack Y, Erlich, Tal H, LaFleur, Martin W, Kemeny, Lajos V, Rashid, Mamunur, Malehmir, Mohsen, Rabi, S Alireza, Raghavan, Rumya, Allouche, Jennifer, Kasumova, Gyulnara, Frederick, Dennie T, Pauken, Kristen E, Weng, Qing Yu, Pereira da Silva, Marcelo, Xu, Yu, van der Sande, Anita A J, Silkworth, Whitney, Roider, Elisabeth, Browne, Edward P, Lieb, David J, Wang, Belinda, Garraway, Levi A, Wu, Catherine J, Flaherty, Keith T, Brinckerhoff, Constance E, Mullins, David W, Adams, David J, Hacohen, Nir, Hoang, Mai P, Boland, Genevieve M, Freeman, Gordon J, Sharpe, Arlene H, Manstein, Dieter, Fisher, David E
Published in Science translational medicine (17.02.2021)
Published in Science translational medicine (17.02.2021)
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Journal Article
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade
Cooper, Zachary A, Juneja, Vikram R, Sage, Peter T, Frederick, Dennie T, Piris, Adriano, Mitra, Devarati, Lo, Jennifer A, Hodi, F Stephen, Freeman, Gordon J, Bosenberg, Marcus W, McMahon, Martin, Flaherty, Keith T, Fisher, David E, Sharpe, Arlene H, Wargo, Jennifer A
Published in Cancer immunology research (01.07.2014)
Published in Cancer immunology research (01.07.2014)
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Journal Article
BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes
Cooper, Zachary A, Frederick, Dennie T, Juneja, Vikram R, Sullivan, Ryan J, Lawrence, Donald P, Piris, Adriano, Sharpe, Arlene H, Fisher, David E, Flaherty, Keith T, Wargo, Jennifer A
Published in Oncoimmunology (01.10.2013)
Published in Oncoimmunology (01.10.2013)
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Journal Article
Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses
Bu, Xia, Juneja, Vikram R, Reynolds, Carol G, Mahoney, Kathleen M, Bu, Melissa T, McGuire, Kathleen A, Maleri, Seth, Hua, Ping, Zhu, Baogong, Klein, Sarah R, Greenfield, Edward A, Armand, Philippe, Ritz, Jerome, Sharpe, Arlene H, Freeman, Gordon J
Published in Cancer immunology research (01.12.2021)
Published in Cancer immunology research (01.12.2021)
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Journal Article
Systematic discovery and validation of T cell targets directed against oncogenic KRAS mutations
Choi, Jaewon, Goulding, Scott P., Conn, Brandon P., McGann, Christopher D., Dietze, Jared L., Kohler, Jessica, Lenkala, Divya, Boudot, Antoine, Rothenberg, Daniel A., Turcott, Paul J., Srouji, John R., Foley, Kendra C., Rooney, Michael S., van Buuren, Marit M., Gaynor, Richard B., Abelin, Jennifer G., Addona, Terri A., Juneja, Vikram R.
Published in Cell reports methods (27.09.2021)
Published in Cell reports methods (27.09.2021)
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Journal Article
Abstract PO-015: Systematic discovery of KRAS neoantigens
Choi, Jaewon, Goulding, Scott P, Conn, Brandon P., McGann, Christopher D., Dietze, Jared L., Kohler, Jessica, Lenkala, Divya R., Boudot, Antoine, Rothenberg, Daniel A., Turcott, Paul J., Srouji, John S., Rooney, Michael S., van Buuren, Marit M., Gaynor, Richard B., Abelin, Jennifer G., Addona, Terri A., Juneja, Vikram R.
Published in Cancer research (Chicago, Ill.) (15.11.2020)
Published in Cancer research (Chicago, Ill.) (15.11.2020)
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Journal Article
Monitoring PD-1 Signaling in Tumor Infiltrating Lymphocytes
Bu, Xia, Juneja, Vikram R., Mahoney, Katheleen M., Renolds, Carol G., Mcguire, Kathleen A., Maleri, Seth, Hua, Ping, Zhu, Baogong, Klein, Sarah R, Greenfield, Edward, Armand, Philippe, Ritz, Jerome, Sharpe, Arlene, Freeman, Gordon J
Published in The Journal of immunology (1950) (01.05.2019)
Published in The Journal of immunology (1950) (01.05.2019)
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Journal Article
Suppression by T sub(FR) cells leads to durable and selective inhibition of B cell effector function
Sage, Peter T, Ron-Harel, Noga, Juneja, Vikram R, Sen, Debattama R, Maleri, Seth, Sungnak, Waradon, Kuchroo, Vijay K, Haining, W Nicholas, Chevrier, Nicolas, Haigis, Marcia, Sharpe, Arlene H
Published in Nature immunology (01.12.2016)
Published in Nature immunology (01.12.2016)
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Journal Article
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
Sage, Peter T, Ron-Harel, Noga, Juneja, Vikram R, Sen, Debattama R, Maleri, Seth, Sungnak, Waradon, Kuchroo, Vijay K, Haining, W Nicholas, Chevrier, Nicolas, Haigis, Marcia, Sharpe, Arlene H
Published in Nature immunology (01.12.2016)
Published in Nature immunology (01.12.2016)
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Journal Article