Search Results - "Jun Kotera" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor

Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor

by Kadoh, Yoichi, Miyoshi, Haruko, Matsumura, Takehiko, Tanaka, Yoshihito, Hongu, Mitsuya, Kimura, Mayumi, Takedomi, Kei, Omori, Kenji, Kotera, Jun, Sasaki, Takashi, Kobayashi, Tamaki, Taniguchi, Hiroyuki, Watanabe, Yumi, Kojima, Koki, Sakamoto, Toshiaki, Himiyama, Toshiyuki, Kawanishi, Eiji
Published in Chemical & pharmaceutical bulletin (2018)

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Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways

Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways

by Yamasaki, Tomohiro, Horie, Takahiro, Koyama, Satoshi, Nakao, Tetsushi, Baba, Osamu, Kimura, Masahiro, Sowa, Naoya, Sakamoto, Kazuhisa, Yamazaki, Kazuhiro, Obika, Satoshi, Kasahara, Yuuya, Kotera, Jun, Oka, Kozo, Fujita, Ryo, Sasaki, Takashi, Takemiya, Akihiro, Hasegawa, Koji, Minatoya, Kenji, Kimura, Takeshi, Ono, Koh
Published in Scientific reports (14.07.2022)

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Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction

Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction

by Kotera, Jun, Mochida, Hideki, Inoue, Hirotaka, Noto, Tsunehisa, Fujishige, Kotomi, Sasaki, Takashi, Kobayashi, Tamaki, Kojima, Koki, Yee, Shiyin, Yamada, Yasuhiro, Kikkawa, Kohei, Omori, Kenji
Published in The Journal of urology (01.08.2012)

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Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability

Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability

by Wang, Run, Burnett, Arthur L, Heller, Warren H, Omori, Kenji, Kotera, Jun, Kikkawa, Kohei, Yee, Shiyin, Day, Wesley W, DiDonato, Karen, Peterson, Craig A
Published in Journal of sexual medicine (01.08.2012)

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The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

by Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Murakami, Michino, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro
Published in Bioorganic & medicinal chemistry letters (01.12.2014)

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Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP

by Handa, Noriko, Mizohata, Eiichi, Kishishita, Seiichiro, Toyama, Mitsutoshi, Morita, Satoshi, Uchikubo-Kamo, Tomomi, Akasaka, Ryogo, Omori, Kenji, Kotera, Jun, Terada, Takaho, Shirouzu, Mikako, Yokoyama, Shigeyuki
Published in The Journal of biological chemistry (11.07.2008)

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Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)

Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)

by Fujishige, K, Kotera, J, Michibata, H, Yuasa, K, Takebayashi, S, Okumura, K, Omori, K
Published in The Journal of biological chemistry (25.06.1999)

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mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

by Van Staveren, Wilma C.G., Steinbusch, Harry W.M., Markerink-Van Ittersum, Marjanne, Repaske, David R., Goy, Michael F., Kotera, Jun, Omori, Kenji, Beavo, Joseph A., De Vente, Jan
Published in Journal of comparative neurology (1911) (22.12.2003)

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Subcellular Localization of Cyclic Nucleotide Phosphodiesterase Type 10A Variants, and Alteration of the Localization by cAMP-dependent Protein Kinase-dependent Phosphorylation

Subcellular Localization of Cyclic Nucleotide Phosphodiesterase Type 10A Variants, and Alteration of the Localization by cAMP-dependent Protein Kinase-dependent Phosphorylation

by Kotera, Jun, Sasaki, Takashi, Kobayashi, Tamaki, Fujishige, Kotomi, Yamashita, Yoko, Omori, Kenji
Published in The Journal of biological chemistry (06.02.2004)

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Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP‐dependent protein kinase/cyclic AMP‐response element binding protein pathway in primary striatal neurons

Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP‐dependent protein kinase/cyclic AMP‐response element binding protein pathway in primary striatal neurons

by Sasaki, Takashi, Kotera, Jun, Omori, Kenji
Published in Journal of neurochemistry (01.04.2004)

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Overview of PDEs and Their Regulation

Overview of PDEs and Their Regulation

by Omori, Kenji, Kotera, Jun
Published in Circulation research (16.02.2007)

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Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation

Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation

by Sasaki, Takashi, Kotera, Jun, Omori, Kenji
Published in Biochemical journal (15.01.2002)

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In Vivo Expression of the Arf6 Guanine-Nucleotide Exchange Factor Cytohesin-1 in Mice Exhibits Enhanced Myelin Thickness in Nerves

In Vivo Expression of the Arf6 Guanine-Nucleotide Exchange Factor Cytohesin-1 in Mice Exhibits Enhanced Myelin Thickness in Nerves

by Torii, Tomohiro, Miyamoto, Yuki, Onami, Naoko, Tsumura, Hideki, Nemoto, Noriko, Kawahara, Katsumasa, Kato, Minoru, Kotera, Jun, Nakamura, Kazuaki, Tanoue, Akito, Yamauchi, Junji
Published in Journal of molecular neuroscience (01.10.2013)

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Immunohistochemical Localization of cGMP-binding cGMP-specific Phosphodiesterase (PDE5) in Rat Tissues

Immunohistochemical Localization of cGMP-binding cGMP-specific Phosphodiesterase (PDE5) in Rat Tissues

by Kotera, Jun, Fujishige, Kotomi, Omori, Kenji
Published in The journal of histochemistry and cytochemistry (01.05.2000)

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Isolation and Characterization of Two Novel Phosphodiesterase PDE11A Variants Showing Unique Structure and Tissue-specific Expression

Isolation and Characterization of Two Novel Phosphodiesterase PDE11A Variants Showing Unique Structure and Tissue-specific Expression

by Yuasa, Keizo, Kotera, Jun, Fujishige, Kotomi, Michibata, Hideo, Sasaki, Takashi, Omori, Kenji
Published in The Journal of biological chemistry (06.10.2000)

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Identification of Human PDE7B, a cAMP-Specific Phosphodiesterase

Identification of Human PDE7B, a cAMP-Specific Phosphodiesterase

by Sasaki, Takashi, Kotera, Jun, Yuasa, Keizo, Omori, Kenji
Published in Biochemical and biophysical research communications (19.05.2000)

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Phosphorylation of Isolated Human Phosphodiesterase-5 Regulatory Domain Induces an Apparent Conformational Change and Increases cGMP Binding Affinity

Phosphorylation of Isolated Human Phosphodiesterase-5 Regulatory Domain Induces an Apparent Conformational Change and Increases cGMP Binding Affinity

by Francis, Sharron H., Bessay, Emmanuel P., Kotera, Jun, Grimes, Kennard A., Liu, Li, Thompson, W. Joseph, Corbin, Jackie D.
Published in The Journal of biological chemistry (06.12.2002)

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Mechanisms Associated with cGMP Binding and Activation of cGMP-Dependent Protein Kinase

Mechanisms Associated with cGMP Binding and Activation of cGMP-Dependent Protein Kinase

by Wall, Michael E., Francis, Sharron H., Corbin, Jackie D., Grimes, Kennard, Richie-Jannetta, Robyn, Kotera, Jun, Macdonald, Brian A., Gibson, Rowena R., Trewhella, Jill
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2003)

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[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

by Corbin, Jackie D, Blount, Mitsi A, Weeks, 2nd, James L, Beasley, Alfreda, Kuhn, Karl P, Ho, Yew S J, Saidi, Layla F, Hurley, James H, Kotera, Jun, Francis, Sharron H
Published in Molecular pharmacology (01.06.2003)

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Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives

Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives

by Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Moritani, Yasunori, Saruta, Kunio, Higashijima, Takanori, Kotera, Jun, Takagi, Michino, Kikkawa, Kohei, Omori, Kenji
Published in Journal of medicinal chemistry (21.06.2001)

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