A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis
Love, Melissa S, Beasley, Federico C, Jumani, Rajiv S, Wright, Timothy M, Chatterjee, Arnab K, Huston, Christopher D, Schultz, Peter G, McNamara, Case W
Published in PLoS neglected tropical diseases (03.02.2017)
Published in PLoS neglected tropical diseases (03.02.2017)
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Journal Article
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Jain, Vitul, Yogavel, Manickam, Kikuchi, Haruhisa, Oshima, Yoshiteru, Hariguchi, Norimitsu, Matsumoto, Makoto, Goel, Preeti, Touquet, Bastien, Jumani, Rajiv S., Tacchini-Cottier, Fabienne, Harlos, Karl, Huston, Christopher D., Hakimi, Mohamed-Ali, Sharma, Amit
Published in Structure (London) (03.10.2017)
Published in Structure (London) (03.10.2017)
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Journal Article
A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
Jumani, Rajiv S., Hasan, Muhammad M., Stebbins, Erin E., Donnelly, Liam, Miller, Peter, Klopfer, Connor, Bessoff, Kovi, Teixeira, Jose E., Love, Melissa S., McNamara, Case W., Huston, Christopher D.
Published in Nature communications (23.04.2019)
Published in Nature communications (23.04.2019)
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Journal Article
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Published in Nature communications (27.06.2019)
Published in Nature communications (27.06.2019)
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Journal Article
Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box
BESSOFF, Kovi, SPANGENBERG, Thomas, FODERARO, Jenna E, JUMANI, Rajiv S, WARD, Gary E, HUSTON, Christopher D
Published in Antimicrobial agents and chemotherapy (01.05.2014)
Published in Antimicrobial agents and chemotherapy (01.05.2014)
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Journal Article
Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation
Hasan, Muhammad M, Mattice, Ethan B, Teixeira, José E, Jumani, Rajiv S, Stebbins, Erin E, Klopfer, Connor E, Franco, Sebastian E, Love, Melissa S, McNamara, Case W, Huston, Christopher D
Published in PLoS pathogens (01.04.2024)
Published in PLoS pathogens (01.04.2024)
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Journal Article
Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model
Stebbins, Erin, Jumani, Rajiv S, Klopfer, Connor, Barlow, John, Miller, Peter, Campbell, Mary A, Meyers, Marvin J, Griggs, David W, Huston, Christopher D
Published in PLoS neglected tropical diseases (01.01.2018)
Published in PLoS neglected tropical diseases (01.01.2018)
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Journal Article
A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box
Jumani, R S, Bessoff, K, Love, M S, Miller, P, Stebbins, E E, Teixeira, J E, Campbell, M A, Meyers, M J, Zambriski, J A, Nunez, V, Woods, A K, McNamara, C W, Huston, C D
Published in Antimicrobial agents and chemotherapy (01.04.2018)
Published in Antimicrobial agents and chemotherapy (01.04.2018)
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Journal Article
The glycosylated Rv1860 protein of Mycobacterium tuberculosis inhibits dendritic cell mediated TH1 and TH17 polarization of T cells and abrogates protective immunity conferred by BCG
Satchidanandam, Vijaya, Kumar, Naveen, Jumani, Rajiv S, Challu, Vijay, Elangovan, Shobha, Khan, Naseem A
Published in PLoS pathogens (01.06.2014)
Published in PLoS pathogens (01.06.2014)
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Journal Article
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Baragan˜a, Beatriz, Forte, Barbara, Choi, Ryan, Hewitt, Stephen Nakazawa, Bueren-Calabuig, Juan A., Pisco, Joa˜o Pedro, Peet, Caroline, Dranow, David M., Robinson, David A., Jansen, Chimed, Norcross, Neil R., Vinayak, Sumiti, Anderson, Mark, Brooks, Carrie F., Cooper, Caitlin A., Damerow, Sebastian, Delves, Michael, Dowers, Karen, Duffy, James, Edwards, Thomas E., Hallyburton, Irene, Horst, Benjamin G., Hulverson, Matthew A., Ferguson, Liam, Jiménez-Díaz, María Belén, Jumani, Rajiv S., Lorimer, Donald D., Love, Melissa S., Maher, Steven, Matthews, Holly, McNamara, Case W., Miller, Peter, O’Neill, Sandra, Ojo, Kayode K., Osuna-Cabello, Maria, Pinto, Erika, Post, John, Riley, Jennifer, Rottmann, Matthias, Sanz, Laura M., Scullion, Paul, Sharma, Arvind, Shepherd, Sharon M., Shishikura, Yoko, Simeons, Frederick R. C., Stebbins, Erin E., Stojanovski, Laste, Straschil, Ursula, Tamaki, Fabio K., Tamjar, Jevgenia, Torrie, Leah S., Vantaux, Amélie, Witkowski, Benoît, Wittlin, Sergio, Yogavel, Manickam, Zuccotto, Fabio, Angulo-Barturen, Iñigo, Sinden, Robert, Baum, Jake, Gamo, Francisco-Javier, Mäser, Pascal, Kyle, Dennis E., Winzeler, Elizabeth A., Myler, Peter J., Wyatt, Paul G., Floyd, David, Matthews, David, Sharma, Amit, Striepen, Boris, Huston, Christopher D., Gray, David W., Fairlamb, Alan H., Pisliakov, Andrei V., Walpole, Chris, Read, Kevin D., Van Voorhis, Wesley C., Gilbert, Ian H.
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2019)
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Journal Article
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase
Vinayak, Sumiti, Jumani, Rajiv S, Miller, Peter, Hasan, Muhammad M, McLeod, Briana I, Tandel, Jayesh, Stebbins, Erin E, Teixeira, Jose E, Borrel, Julien, Gonse, Arthur, Zhang, Mingliang, Yu, Xianshui, Wernimont, Amy, Walpole, Chris, Eckley, Sean, Love, Melissa S, McNamara, Case W, Sharma, Manmohan, Sharma, Amit, Scherer, Christina A, Kato, Nobutaka, Schreiber, Stuart L, Melillo, Bruno, Striepen, Boris, Huston, Christopher D, Comer, Eamon
Published in Science translational medicine (30.09.2020)
Published in Science translational medicine (30.09.2020)
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Journal Article
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
Rao, Srinivasa P S, Gould, Matthew K, Noeske, Jonas, Saldivia, Manuel, Jumani, Rajiv S, Ng, Pearly S, René, Olivier, Chen, Yen-Liang, Kaiser, Marcel, Ritchie, Ryan, Francisco, Amanda Fortes, Johnson, Nila, Patra, Debjani, Cheung, Harry, Deniston, Colin, Schenk, Andreas D, Cortopassi, Wilian A, Schmidt, Remo S, Wiedemar, Natalie, Thomas, Bryanna, Palkar, Rima, Ghafar, Nahdiyah A, Manoharan, Vanessa, Luu, Catherine, Gable, Jonathan E, Wan, Kah Fei, Myburgh, Elmarie, Mottram, Jeremy C, Barnes, Whitney, Walker, John, Wartchow, Charles, Aziz, Natasha, Osborne, Colin, Wagner, Juergen, Sarko, Christopher, Kelly, John M, Manjunatha, Ujjini H, Mäser, Pascal, Jiricek, Jan, Lakshminarayana, Suresh B, Barrett, Michael P, Diagana, Thierry T
Published in Science (American Association for the Advancement of Science) (30.06.2023)
Published in Science (American Association for the Advancement of Science) (30.06.2023)
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Journal Article
The first Cryptosporidium meeting: a concerted effort to fight cryptosporidiosis
van Voorhis, Wes, Siwila, Joyce, Kissinger, Jessica C., Vásquez, Natalia Bayona, Robinson, Guy, Baptista, Rodrigo, Khan, Asis, Guérin, Amandine, Chang, Yi-Wei, Noor, Zannatun, Marzook, N. Bishara, Vinayak, Sumiti, Arnold, Sam, Marie, Chelsea, Choy, Robert K.M., Pawlowic, Mattie C., Jumani, Rajiv S.
Published in Trends in parasitology (01.06.2024)
Published in Trends in parasitology (01.06.2024)
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Journal Article
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection
Buckner, Frederick S, Ranade, Ranae M, Gillespie, J Robert, Shibata, Sayaka, Hulverson, Matthew A, Zhang, Zhongsheng, Huang, Wenlin, Choi, Ryan, Verlinde, Christophe L M J, Hol, Wim G J, Ochida, Atsuko, Akao, Yuichiro, Choy, Robert K M, Van Voorhis, Wesley C, Arnold, Sam L M, Jumani, Rajiv S, Huston, Christopher D, Fan, Erkang
Published in Antimicrobial agents and chemotherapy (01.04.2019)
Published in Antimicrobial agents and chemotherapy (01.04.2019)
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Journal Article
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor
Osman, Khan T., Ye, Juntao, Shi, Zhihao, Toker, Christina, Lovato, Diogo, Jumani, Rajiv S., Zuercher, William, Huston, Christopher D., Edwards, Aled M., Lautens, Mark, Santhakumar, Vijayaratnam, Hui, Raymond
Published in Bioorganic & medicinal chemistry (01.03.2017)
Published in Bioorganic & medicinal chemistry (01.03.2017)
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Journal Article
The Secreted Protein Rv1860 of Mycobacterium tuberculosis Stimulates Human Polyfunctional CD8+ T Cells
Satchidanandam, Vijaya, Kumar, Naveen, Biswas, Sunetra, Jumani, Rajiv S, Jain, Chandni, Rani, Rajni, Aggarwal, Bharti, Singh, Jaya, Kotnur, Mohan Rao, Sridharan, Anand
Published in Clinical and vaccine immunology (01.04.2016)
Published in Clinical and vaccine immunology (01.04.2016)
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Journal Article
Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents
Jumani, Rajiv S, Blais, Johanne, Tillmann, Hanns-Christian, Segal, Florencia, Wetty, Dean, Ostermeier, Christian, Nuber, Natko, Lakshman, Jay, Aziz, Natasha, Chandra, Richa, Chen, Wilbur H, Chappell, Cynthia L, Diagana, Thierry T, Manjunatha, Ujjini H
Published in ACS infectious diseases (14.05.2021)
Published in ACS infectious diseases (14.05.2021)
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Journal Article
Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis
Manjunatha, Ujjini H., Lakshminarayana, Suresh B., Jumani, Rajiv S., Chao, Alexander T., Young, Joseph M., Gable, Jonathan E., Knapp, Mark, Hanna, Imad, Galarneau, Jean-Rene, Cantwell, John, Kulkarni, Upendra, Turner, Michael, Lu, Peichao, Darrell, Kristen H., Watson, Lucy C., Chan, Katherine, Patra, Debjani, Mamo, Mulugeta, Luu, Catherine, Cuellar, Carlos, Shaul, Jacob, Xiao, Linda, Chen, Ying-Bo, Carney, Shannon K., Lakshman, Jay, Osborne, Colin S., Zambriski, Jennifer A., Aziz, Natasha, Sarko, Christopher, Diagana, Thierry T.
Published in Nature microbiology (08.10.2024)
Published in Nature microbiology (08.10.2024)
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Journal Article
Retrospective investigation of the effects and efficiency of self-ligating and conventional brackets
Anand, Megha, Turpin, David L, Jumani, Ketan S, Spiekerman, Charles F, Huang, Greg J
Published in American journal of orthodontics and dentofacial orthopedics (01.07.2015)
Published in American journal of orthodontics and dentofacial orthopedics (01.07.2015)
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