Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding
Trimpert, Jakob, Dietert, Kristina, Firsching, Theresa C., Ebert, Nadine, Thi Nhu Thao, Tran, Vladimirova, Daria, Kaufer, Susanne, Labroussaa, Fabien, Abdelgawad, Azza, Conradie, Andelé, Höfler, Thomas, Adler, Julia M., Bertzbach, Luca D., Jores, Joerg, Gruber, Achim D., Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan
Published in Cell reports (Cambridge) (03.08.2021)
Published in Cell reports (Cambridge) (03.08.2021)
Get full text
Journal Article
An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission
Adler, Julia M., Martin Vidal, Ricardo, Langner, Christine, Vladimirova, Daria, Abdelgawad, Azza, Kunecova, Daniela, Lin, Xiaoyuan, Nouailles, Geraldine, Voss, Anne, Kunder, Sandra, Gruber, Achim D., Wu, Haibo, Osterrieder, Nikolaus, Kunec, Dusan, Trimpert, Jakob
Published in Nature communications (02.02.2024)
Published in Nature communications (02.02.2024)
Get full text
Journal Article
Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence
Tolksdorf, Beatrice, Nie, Chuanxiong, Niemeyer, Daniela, Röhrs, Viola, Berg, Johanna, Lauster, Daniel, Adler, Julia M., Haag, Rainer, Trimpert, Jakob, Kaufer, Benedikt, Drosten, Christian, Kurreck, Jens
Published in Viruses (08.10.2021)
Published in Viruses (08.10.2021)
Get full text
Journal Article
The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters
Shytaj, Iart Luca, Fares, Mohamed, Gallucci, Lara, Lucic, Bojana, Tolba, Mahmoud M, Zimmermann, Liv, Adler, Julia M, Xing, Na, Bushe, Judith, Gruber, Achim D, Ambiel, Ina, Taha Ayoub, Ahmed, Cortese, Mirko, Neufeldt, Christopher J, Stolp, Bettina, Sobhy, Mohamed Hossam, Fathy, Moustafa, Zhao, Min, Laketa, Vibor, Diaz, Ricardo Sobhie, Sutton, Richard E, Chlanda, Petr, Boulant, Steeve, Bartenschlager, Ralf, Stanifer, Megan L, Fackler, Oliver T, Trimpert, Jakob, Savarino, Andrea, Lusic, Marina
Published in mBio (26.04.2022)
Published in mBio (26.04.2022)
Get full text
Journal Article
Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19
Peidli, Stefan, Nouailles, Geraldine, Wyler, Emanuel, Adler, Julia M., Kunder, Sandra, Voß, Anne, Kazmierski, Julia, Pott, Fabian, Pennitz, Peter, Postmus, Dylan, Teixeira Alves, Luiz Gustavo, Goffinet, Christine, Gruber, Achim D., Blüthgen, Nils, Witzenrath, Martin, Trimpert, Jakob, Landthaler, Markus, Praktiknjo, Samantha D.
Published in Cell reports (Cambridge) (25.06.2024)
Published in Cell reports (Cambridge) (25.06.2024)
Get full text
Journal Article
In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs ® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2
Emanuel, Jackson, Papies, Jan, Galander, Celine, Adler, Julia M, Heinemann, Nicolas, Eschke, Kathrin, Merz, Sophie, Pischon, Hannah, Rose, Ruben, Krumbholz, Andi, Kulić, Žarko, Lehner, Martin D, Trimpert, Jakob, Müller, Marcel A
Published in Frontiers in pharmacology (26.07.2023)
Published in Frontiers in pharmacology (26.07.2023)
Get full text
Journal Article
Early protective effect of a ("pan") coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration
Abdelaziz, Mohammed O, Raftery, Martin J, Weihs, Julian, Bielawski, Olivia, Edel, Richard, Köppke, Julia, Vladimirova, Daria, Adler, Julia M, Firsching, Theresa, Voß, Anne, Gruber, Achim D, Hummel, Luca V, Fernandez Munoz, Ivan, Müller-Marquardt, Francesca, Willimsky, Gerald, Elleboudy, Nooran S, Trimpert, Jakob, Schönrich, Günther
Published in Frontiers in immunology (13.07.2023)
Published in Frontiers in immunology (13.07.2023)
Get full text
Journal Article
Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters
Trimpert, Jakob, Herwig, Susanne, Stein, Julia, Vladimirova, Daria, Adler, Julia M, Abdelgawad, Azza, Firsching, Theresa C, Thoma, Tizia, Sehouli, Jalid, Osterrieder, Klaus, Gruber, Achim D, Sawitzki, Birgit, Sander, Leif Erik, Cichon, Günter
Published in Viruses (16.11.2021)
Published in Viruses (16.11.2021)
Get full text
Journal Article
Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron
Kreye, Jakob, Reincke, S. Momsen, Edelburg, Stefan, Jeworowski, Lara M., Kornau, Hans-Christian, Trimpert, Jakob, Hombach, Peter, Halbe, Sophia, Nölle, Volker, Meyer, Martin, Kattenbach, Stefanie, Sánchez-Sendin, Elisa, Schmidt, Marie L., Schwarz, Tatjana, Rose, Ruben, Krumbholz, Andi, Merz, Sophie, Adler, Julia M., Eschke, Kathrin, Abdelgawad, Azza, Schmitz, Dietmar, Sander, Leif E., Janssen, Uwe, Corman, Victor M., Prüss, Harald
Published in iScience (21.04.2023)
Published in iScience (21.04.2023)
Get full text
Journal Article
Virus-induced senescence is a driver and therapeutic target in COVID-19
Lee, Soyoung, Yu, Yong, Trimpert, Jakob, Benthani, Fahad, Mairhofer, Mario, Richter-Pechanska, Paulina, Wyler, Emanuel, Belenki, Dimitri, Kaltenbrunner, Sabine, Pammer, Maria, Kausche, Lea, Firsching, Theresa C., Dietert, Kristina, Schotsaert, Michael, Martínez-Romero, Carles, Singh, Gagandeep, Kunz, Séverine, Niemeyer, Daniela, Ghanem, Riad, Salzer, Helmut J. F., Paar, Christian, Mülleder, Michael, Uccellini, Melissa, Michaelis, Edward G., Khan, Amjad, Lau, Andrea, Schönlein, Martin, Habringer, Anna, Tomasits, Josef, Adler, Julia M., Kimeswenger, Susanne, Gruber, Achim D., Hoetzenecker, Wolfram, Steinkellner, Herta, Purfürst, Bettina, Motz, Reinhard, Di Pierro, Francesco, Lamprecht, Bernd, Osterrieder, Nikolaus, Landthaler, Markus, Drosten, Christian, García-Sastre, Adolfo, Langer, Rupert, Ralser, Markus, Eils, Roland, Reimann, Maurice, Fan, Dorothy N. Y., Schmitt, Clemens A.
Published in Nature (London) (11.11.2021)
Published in Nature (London) (11.11.2021)
Get full text
Journal Article
A non-transmissible live attenuated SARS-CoV-2 vaccine
Adler, Julia M., Martin Vidal, Ricardo, Voß, Anne, Kunder, Sandra, Nascimento, Mariana, Abdelgawad, Azza, Langner, Christine, Vladimirova, Daria, Osterrieder, Nikolaus, Gruber, Achim D., Kunec, Dusan, Trimpert, Jakob
Published in Molecular therapy (02.08.2023)
Published in Molecular therapy (02.08.2023)
Get full text
Journal Article
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Wyler, Emanuel, Adler, Julia M., Eschke, Kathrin, Teixeira Alves, G., Peidli, Stefan, Pott, Fabian, Kazmierski, Julia, Michalick, Laura, Kershaw, Olivia, Bushe, Judith, Andreotti, Sandro, Pennitz, Peter, Abdelgawad, Azza, Postmus, Dylan, Goffinet, Christine, Kreye, Jakob, Reincke, S Momsen, Prüss, Harald, Blüthgen, Nils, Gruber, Achim D., Kuebler, Wolfgang M., Witzenrath, Martin, Landthaler, Markus, Nouailles, Geraldine, Trimpert, Jakob
Published in Molecular therapy (04.05.2022)
Published in Molecular therapy (04.05.2022)
Get full text
Journal Article
Functionalized Fullerene for Inhibition of SARS‐CoV‐2 Variants
Page, Taylor M., Nie, Chuanxiong, Neander, Lenard, Povolotsky, Tatyana L., Sahoo, Anil Kumar, Nickl, Philip, Adler, Julia M., Bawadkji, Obida, Radnik, Jörg, Achazi, Katharina, Ludwig, Kai, Lauster, Daniel, Netz, Roland R., Trimpert, Jakob, Kaufer, Benedikt, Haag, Rainer, Donskyi, Ievgen S.
Published in Small (Weinheim an der Bergstrasse, Germany) (01.04.2023)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.04.2023)
Get full text
Journal Article
Mucus‐Inspired Self‐Healing Hydrogels: A Protective Barrier for Cells against Viral Infection
Bej, Raju, Stevens, Corey Alfred, Nie, Chuanxiong, Ludwig, Kai, Degen, George D., Kerkhoff, Yannic, Pigaleva, Marina, Adler, Julia M., Bustos, Nicole A., Page, Taylor M., Trimpert, Jakob, Block, Stephan, Kaufer, Benedikt B., Ribbeck, Katharina, Haag, Rainer
Published in Advanced materials (Weinheim) (01.08.2024)
Published in Advanced materials (Weinheim) (01.08.2024)
Get full text
Journal Article
Mucin‐Inspired Single‐Chain Polymer (MIP) Fibers as Potent SARS‐CoV‐2 Inhibitors
Bej, Raju, Nie, Chuanxiong, Ludwig, Kai, Ahmadi, Vahid, Trimpert, Jakob, Adler, Julia M., Povolotsky, Tatyana L., Achazi, Katharina, Kagelmacher, Marten, Vidal, Ricardo Martin, Dernedde, Jens, Kaufer, Benedikt B., Haag, Rainer
Published in Angewandte Chemie International Edition (17.07.2023)
Published in Angewandte Chemie International Edition (17.07.2023)
Get full text
Journal Article
Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants
Mühlemann, Barbara, Trimpert, Jakob, Walper, Felix, Schmidt, Marie L, Jansen, Jenny, Schroeder, Simon, Jeworowski, Lara M, Beheim-Schwarzbach, Jörn, Bleicker, Tobias, Niemeyer, Daniela, Richter, Anja, Adler, Julia M, Vidal, Ricardo Martin, Langner, Christine, Vladimirova, Daria, Wilks, Samuel H, Smith, Derek J, Voß, Mathias, Paltzow, Lea, Martínez Christophersen, Christina, Rose, Ruben, Krumbholz, Andi, Jones, Terry C, Corman, Victor M, Drosten, Christian
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
Get full text
Journal Article
Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)
Trimpert, Jakob, Adler, Julia M, Eschke, Kathrin, Abdelgawad, Azza, Firsching, Theresa C, Ebert, Nadine, Thao, Tran Thi Nhu, Gruber, Achim D, Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan
Published in Science advances (03.12.2021)
Published in Science advances (03.12.2021)
Get full text
Journal Article
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Nouailles, Geraldine, Adler, Julia M., Pennitz, Peter, Peidli, Stefan, Teixeira Alves, Luiz Gustavo, Baumgardt, Morris, Bushe, Judith, Voss, Anne, Langenhagen, Alina, Langner, Christine, Martin Vidal, Ricardo, Pott, Fabian, Kazmierski, Julia, Ebenig, Aileen, Lange, Mona V., Mühlebach, Michael D., Goekeri, Cengiz, Simmons, Szandor, Xing, Na, Abdelgawad, Azza, Herwig, Susanne, Cichon, Günter, Niemeyer, Daniela, Drosten, Christian, Goffinet, Christine, Landthaler, Markus, Blüthgen, Nils, Wu, Haibo, Witzenrath, Martin, Gruber, Achim D., Praktiknjo, Samantha D., Osterrieder, Nikolaus, Wyler, Emanuel, Kunec, Dusan, Trimpert, Jakob
Published in Nature microbiology (01.05.2023)
Published in Nature microbiology (01.05.2023)
Get full text
Journal Article
Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease
Friedrich, Vincent D., Pennitz, Peter, Wyler, Emanuel, Adler, Julia M., Postmus, Dylan, Müller, Kristina, Teixeira Alves, Luiz Gustavo, Prigann, Julia, Pott, Fabian, Vladimirova, Daria, Hoefler, Thomas, Goekeri, Cengiz, Landthaler, Markus, Goffinet, Christine, Saliba, Antoine-Emmanuel, Scholz, Markus, Witzenrath, Martin, Trimpert, Jakob, Kirsten, Holger, Nouailles, Geraldine
Published in EBioMedicine (01.10.2024)
Published in EBioMedicine (01.10.2024)
Get full text
Journal Article