Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial
Salminen, Paulina, Tuominen, Risto, Paajanen, Hannu, Rautio, Tero, Nordström, Pia, Aarnio, Markku, Rantanen, Tuomo, Hurme, Saija, Mecklin, Jukka-Pekka, Sand, Juhani, Virtanen, Johanna, Jartti, Airi, Grönroos, Juha M
Published in JAMA : the journal of the American Medical Association (25.09.2018)
Published in JAMA : the journal of the American Medical Association (25.09.2018)
Get full text
Journal Article
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
Burn, John, Sheth, Harsh, Elliott, Faye, Reed, Lynn, Macrae, Finlay, Mecklin, Jukka-Pekka, Möslein, Gabriela, McRonald, Fiona E, Bertario, Lucio, Evans, D Gareth, Gerdes, Anne-Marie, Ho, Judy W C, Lindblom, Annika, Morrison, Patrick J, Rashbass, Jem, Ramesar, Raj, Seppälä, Toni, Thomas, Huw J W, Pylvänäinen, Kirsi, Borthwick, Gillian M, Mathers, John C, Bishop, D Timothy, Boussioutas, Alex, Brewer, Carole, Cook, Jackie, Eccles, Diana, Ellis, Anthony, Hodgson, Shirley V, Lubinski, Jan, Maher, Eamonn R, Porteous, Mary EM, Sampson, Julian, Scott, Rodney J, Side, Lucy
Published in The Lancet (British edition) (13.06.2020)
Published in The Lancet (British edition) (13.06.2020)
Get full text
Journal Article
Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status
Ahtiainen, Maarit, Wirta, Erkki-Ville, Kuopio, Teijo, Seppälä, Toni, Rantala, Juha, Mecklin, Jukka-Pekka, Böhm, Jan
Published in Modern pathology (01.06.2019)
Published in Modern pathology (01.06.2019)
Get full text
Journal Article
Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study
Porkka, Noora, Lahtinen, Laura, Ahtiainen, Maarit, Böhm, Jan P., Kuopio, Teijo, Eldfors, Samuli, Mecklin, Jukka‐Pekka, Seppälä, Toni T., Peltomäki, Päivi
Published in International journal of cancer (01.07.2019)
Published in International journal of cancer (01.07.2019)
Get full text
Journal Article
Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
Tahkola, Kyösti, Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Kellokumpu, Ilmo, Laukkarinen, Johanna, Tammi, Markku, Tammi, Raija, Väyrynen, Juha P., Böhm, Jan
Published in Scientific reports (09.06.2021)
Published in Scientific reports (09.06.2021)
Get full text
Journal Article
Systemic circulating microRNA landscape in Lynch syndrome
Sievänen, Tero, Korhonen, Tia-Marje, Jokela, Tiina, Ahtiainen, Maarit, Lahtinen, Laura, Kuopio, Teijo, Lepistö, Anna, Sillanpää, Elina, Mecklin, Jukka-Pekka, Seppälä, Toni T, Laakkonen, Eija K
Published in International journal of cancer (01.03.2023)
Published in International journal of cancer (01.03.2023)
Get full text
Journal Article
The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome
Watson, Patrice, Vasen, Hans F.A., Mecklin, Jukka‐Pekka, Bernstein, Inge, Aarnio, Markku, Järvinen, Heikki J., Myrhøj, Torben, Sunde, Lone, Wijnen, Juul T., Lynch, Henry T.
Published in International journal of cancer (15.07.2008)
Published in International journal of cancer (15.07.2008)
Get full text
Journal Article
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
Ballhausen, Alexej, Przybilla, Moritz Jakob, Jendrusch, Michael, Haupt, Saskia, Pfaffendorf, Elisabeth, Seidler, Florian, Witt, Johannes, Hernandez Sanchez, Alejandro, Urban, Katharina, Draxlbauer, Markus, Krausert, Sonja, Ahadova, Aysel, Kalteis, Martin Simon, Pfuderer, Pauline L., Heid, Daniel, Stichel, Damian, Gebert, Johannes, Bonsack, Maria, Schott, Sarah, Bläker, Hendrik, Seppälä, Toni, Mecklin, Jukka-Pekka, Ten Broeke, Sanne, Nielsen, Maartje, Heuveline, Vincent, Krzykalla, Julia, Benner, Axel, Riemer, Angelika Beate, von Knebel Doeberitz, Magnus, Kloor, Matthias
Published in Nature communications (21.09.2020)
Published in Nature communications (21.09.2020)
Get full text
Journal Article
Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer
Mäki‐Nevala, Satu, Ukwattage, Sanjeevi, Olkinuora, Alisa, Almusa, Henrikki, Ahtiainen, Maarit, Ristimäki, Ari, Seppälä, Toni, Lepistö, Anna, Mecklin, Jukka‐Pekka, Peltomäki, Päivi
Published in International journal of cancer (15.06.2021)
Published in International journal of cancer (15.06.2021)
Get full text
Journal Article
The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski‐Feder, Elke, Steinke‐Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Broeke, Sanne W., Laghi, Luigi, Dominguez‐Valentin, Mev, Capella, Gabriel, Macrae, Finlay, Scott, Rodney, Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka‐Pekka, Møller, Pål, Kloor, Matthias
Published in International journal of cancer (15.02.2021)
Published in International journal of cancer (15.02.2021)
Get full text
Journal Article
Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance
Niskakoski, Anni, Pasanen, Annukka, Lassus, Heini, Renkonen-Sinisalo, Laura, Kaur, Sippy, Mecklin, Jukka-Pekka, Bützow, Ralf, Peltomäki, Päivi
Published in Modern pathology (01.08.2018)
Published in Modern pathology (01.08.2018)
Get full text
Journal Article
Appendiceal neoplasm risk associated with complicated acute appendicitis—a population based study
Lietzén, Elina, Grönroos, Juha M., Mecklin, Jukka-Pekka, Leppäniemi, Ari, Nordström, Pia, Rautio, Tero, Rantanen, Tuomo, Sand, Juhani, Paajanen, Hannu, Kaljonen, Anne, Salminen, Paulina
Published in International journal of colorectal disease (31.01.2019)
Published in International journal of colorectal disease (31.01.2019)
Get full text
Journal Article
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
Møller, Pål, Seppälä, Toni, Bernstein, Inge, Holinski-Feder, Elke, Sala, Paola, Evans, D Gareth, Lindblom, Annika, Macrae, Finlay, Blanco, Ignacio, Sijmons, Rolf, Jeffries, Jacqueline, Vasen, Hans, Burn, John, Nakken, Sigve, Hovig, Eivind, Rødland, Einar Andreas, Tharmaratnam, Kukatharmini, de Vos tot Nederveen Cappel, Wouter H, Hill, James, Wijnen, Juul, Jenkins, Mark, Green, Kate, Lalloo, Fiona, Sunde, Lone, Mints, Miriam, Bertario, Lucio, Pineda, Marta, Navarro, Matilde, Morak, Monika, Renkonen-Sinisalo, Laura, Frayling, Ian M, Plazzer, John-Paul, Pylvanainen, Kirsi, Genuardi, Maurizio, Mecklin, Jukka-Pekka, Möslein, Gabriela, Sampson, Julian R, Capella, Gabriel
Published in Gut (01.09.2017)
Published in Gut (01.09.2017)
Get full text
Journal Article
Germline Mutation of RPS20 , Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency
Nieminen, Taina T, O’Donohue, Marie-Françoise, Wu, Yunpeng, Lohi, Hannes, Scherer, Stephen W, Paterson, Andrew D, Ellonen, Pekka, Abdel-Rahman, Wael M, Valo, Satu, Mecklin, Jukka-Pekka, Järvinen, Heikki J, Gleizes, Pierre-Emmanuel, Peltomäki, Päivi
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2014)
Get full text
Journal Article
Is HLA type a possible cancer risk modifier in Lynch syndrome?
Ahadova, Aysel, Witt, Johannes, Haupt, Saskia, Gallon, Richard, Hüneburg, Robert, Nattermann, Jacob, Broeke, Sanne, Bohaumilitzky, Lena, Hernandez‐Sanchez, Alejandro, Santibanez‐Koref, Mauro, Jackson, Michael S., Ahtiainen, Maarit, Pylvänäinen, Kirsi, Andini, Katarina, Grolmusz, Vince Kornel, Möslein, Gabriela, Dominguez‐Valentin, Mev, Møller, Pål, Fürst, Daniel, Sijmons, Rolf, Borthwick, Gillian M., Burn, John, Mecklin, Jukka‐Pekka, Heuveline, Vincent, Knebel Doeberitz, Magnus, Seppälä, Toni, Kloor, Matthias
Published in International journal of cancer (15.05.2023)
Published in International journal of cancer (15.05.2023)
Get full text
Journal Article
Ten Years After Mutation Testing for Lynch Syndrome: Cancer Incidence and Outcome in Mutation-Positive and Mutation-Negative Family Members
Järvinen, Heikki J., Renkonen-Sinisalo, Laura, Aktán-Collán, Katja, Peltomäki, Päivi, Aaltonen, Lauri A., Mecklin, Jukka-Pekka
Published in Journal of clinical oncology (01.10.2009)
Published in Journal of clinical oncology (01.10.2009)
Get full text
Journal Article
Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer
Junttila, Anna, Helminen, Olli, Väyrynen, Juha P., Ahtiainen, Maarit, Kenessey, Istvan, Jalkanen, Sirpa, Mecklin, Jukka-Pekka, Kellokumpu, Ilmo, Kuopio, Teijo, Böhm, Jan, Mrena, Johanna
Published in British journal of cancer (24.11.2020)
Published in British journal of cancer (24.11.2020)
Get full text
Journal Article
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
Taipale, Jussi, Aaltonen, Lauri A, Tuupanen, Sari, Turunen, Mikko, Lehtonen, Rainer, Hallikas, Outi, Vanharanta, Sakari, Kivioja, Teemu, Björklund, Mikael, Wei, Gonghong, Yan, Jian, Niittymäki, Iina, Mecklin, Jukka-Pekka, Järvinen, Heikki, Ristimäki, Ari, Di-Bernardo, Mariachiara, East, Phil, Carvajal-Carmona, Luis, Houlston, Richard S, Tomlinson, Ian, Palin, Kimmo, Ukkonen, Esko, Karhu, Auli
Published in Nature genetics (01.08.2009)
Published in Nature genetics (01.08.2009)
Get full text
Journal Article
Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry
Zalevskaja, Kristina, Mecklin, Jukka-Pekka, Seppälä, Toni T
Published in Frontiers in oncology (01.02.2023)
Published in Frontiers in oncology (01.02.2023)
Get full text
Journal Article