An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
Qi, Wei, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Man, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chan, HoMan, Chen, Zijun, Fang, Douglas, Fei, Qi, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Li, Guobin, Lingel, Andreas, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter, Li, En
Published in Nature chemical biology (01.04.2017)
Published in Nature chemical biology (01.04.2017)
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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
Qi, Wei, Chan, HoMan, Tenga, Lin, Li, Ling, Chuai, Shannon, Zhang, Ruipeng, Zeng, Jue, Li, Min, Fan, Hong, Lin, Ying, Gu, Justin, Ardayfio, Ophelia, Zhang, Ji-Hu, Yan, Xiaoxia, Fang, Jialuo, Mi, Yuan, Zhang, Man, Zhou, Tao, Feng, Grace, Chen, Zijun, Li, Guobin, Yang, Teddy, Zhao, Kehao, Liu, Xianghui, Yu, Zhengtian, Lu, Chris X., Atadja, Peter, Li, En
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
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Multi-century flow reconstruction of the Lhasa River, China
Zeng, Jue, Yu, Bofu, Fu, Xudong, Hu, Hongchang
Published in Journal of hydrology. Regional studies (01.06.2024)
Published in Journal of hydrology. Regional studies (01.06.2024)
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Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53
Wang, Ting, Zeng, Jue, Lowe, Craig B, Sellers, Robert G, Salama, Sofie R, Yang, Min, Burgess, Shawn M, Brachmann, Rainer K, Haussler, David
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
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Journal Article
Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase
Lingel, Andreas, Sendzik, Martin, Huang, Ying, Shultz, Michael D, Cantwell, John, Dillon, Michael P, Fu, Xingnian, Fuller, John, Gabriel, Tobias, Gu, Justin, Jiang, Xiangqing, Li, Ling, Liang, Fang, McKenna, Maureen, Qi, Wei, Rao, Weijun, Sheng, Xijun, Shu, Wei, Sutton, James, Taft, Benjamin, Wang, Long, Zeng, Jue, Zhang, Hailong, Zhang, Maya, Zhao, Kehao, Lindvall, Mika, Bussiere, Dirksen E
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
Split luciferase-based biosensors for characterizing EED binders
Li, Ling, Feng, Lijian, Shi, Minlong, Zeng, Jue, Chen, Zijun, Zhong, Li, Huang, Li, Guo, Weihui, Huang, Ying, Qi, Wei, Lu, Chris, Li, En, Zhao, Kehao, Gu, Justin
Published in Analytical biochemistry (01.04.2017)
Published in Analytical biochemistry (01.04.2017)
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Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers
Dearth, Lawrence R., Qian, Hua, Wang, Ting, Baroni, Timothy E., Zeng, Jue, Chen, Stephanie W., Yi, Sun Young, Brachmann, Rainer K.
Published in Carcinogenesis (New York) (01.02.2007)
Published in Carcinogenesis (New York) (01.02.2007)
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Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants
Danziger, S.A., Swamidass, S.J., Jue Zeng, Dearth, L.R., Qiang Lu, Chen, J.H., Cheng, J., Hoang, V.P., Saigo, H., Luo, R., Baldi, P., Brachmann, R.K., Lathrop, R.H.
Published in IEEE/ACM transactions on computational biology and bioinformatics (01.04.2006)
Published in IEEE/ACM transactions on computational biology and bioinformatics (01.04.2006)
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MAGED2 : A novel p53-dissociator
PAPAGEORGIO, Chris, BRACHMANN, Rainer, JUE ZENG, CULVERHOUSE, Robert, WANGHAI ZHANG, MCLEOD, Howard
Published in International journal of oncology (01.11.2007)
Published in International journal of oncology (01.11.2007)
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Journal Article
A Global Suppressor Motif for p53 Cancer Mutants
Baroni, Timothy E., Wang, Ting, Qian, Hua, Dearth, Lawrence R., Truong, Lan N., Zeng, Jue, Denes, Alec E., Chen, Stephanie W., Brachmann, Rainer K., Korsmeyer, Stanley J.
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2004)
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Study on superplastic behaviour of cold rolled Inconel 718 alloy with δ phase dispersion distribution
Zeng, Jue, Huang, Yuqi, Yang, Xu, Wang, Bingxing, Wang, Bin
Published in Materials technology (New York, N.Y.) (31.12.2023)
Published in Materials technology (New York, N.Y.) (31.12.2023)
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SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia
Chen, Xiaohe, Zhao, Lifen, Yu, Tian, Zeng, Jue, Chen, Ming
Published in American journal of translational research (01.01.2022)
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Published in American journal of translational research (01.01.2022)
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miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2
Chen, Xiaohe, Yang, Shouhang, Zeng, Jue, Chen, Ming
Published in Molecular medicine reports (01.01.2019)
Published in Molecular medicine reports (01.01.2019)
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Journal Article
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
Huang, Ying, Zhang, Jeff, Yu, Zhengtian, Zhang, Hailong, Wang, Youzhen, Lingel, Andreas, Qi, Wei, Gu, Justin, Zhao, Kehao, Shultz, Michael D, Wang, Long, Fu, Xingnian, Sun, Yongfeng, Zhang, Qiong, Jiang, Xiangqing, Zhang, Jiangwei, Zhang, Chunye, Li, Ling, Zeng, Jue, Feng, Lijian, Zhang, Chao, Liu, Yueqin, Zhang, Man, Zhang, Lijun, Zhao, Mengxi, Gao, Zhenting, Liu, Xianghui, Fang, Douglas, Guo, Haibing, Mi, Yuan, Gabriel, Tobias, Dillon, Michael P, Atadja, Peter, Oyang, Counde
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Journal Article
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies
Huang, Ying, Sendzik, Martin, Zhang, Jeff, Gao, Zhenting, Sun, Yongfeng, Wang, Long, Gu, Justin, Zhao, Kehao, Yu, Zhengtian, Zhang, Lijun, Zhang, Qiong, Blanz, Joachim, Chen, Zijun, Dubost, Valérie, Fang, Douglas, Feng, Lijian, Fu, Xingnian, Kiffe, Michael, Li, Ling, Luo, Fangjun, Luo, Xiao, Mi, Yuan, Mistry, Prakash, Pearson, David, Piaia, Alessandro, Scheufler, Clemens, Terranova, Remi, Weiss, Andreas, Zeng, Jue, Zhang, Hailong, Zhang, Jiangwei, Zhao, Mengxi, Dillon, Michael P, Jeay, Sebastien, Qi, Wei, Moggs, Jonathan, Pissot-Soldermann, Carole, Li, En, Atadja, Peter, Lingel, Andreas, Oyang, Counde
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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