Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
Ghonim, Mohamed A, Ju, Jihang, Pyakurel, Kusma, Ibba, Salome V, Abouzeid, Mai M, Rady, Hamada F, Matsuyama, Shigemi, Del Valle, Luis, Boulares, A Hamid
Published in Journal of inflammation (London, England) (30.04.2024)
Published in Journal of inflammation (London, England) (30.04.2024)
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Journal Article
NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs
Wen, Zhenke, Shimojima, Yasuhiro, Shirai, Tsuyoshi, Li, Yinyin, Ju, Jihang, Yang, Zhen, Tian, Lu, Goronzy, Jörg J., Weyand, Cornelia M.
Published in The Journal of clinical investigation (02.05.2016)
Published in The Journal of clinical investigation (02.05.2016)
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DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4+ T-cell function without causing severe combined immunodeficiency
Ghonim, Mohamed A., MS, Pyakurel, Kusma, BS, Ju, Jihang, PhD, Rodriguez, Paulo C., PhD, Lammi, Matthew R., MD, Davis, Christian, Abughazleh, Mohammad Q., BS, Mansy, Moselhy S., PhD, Naura, Amarjit S., PhD, Boulares, A. Hamid, PhD
Published in Journal of allergy and clinical immunology (01.02.2015)
Published in Journal of allergy and clinical immunology (01.02.2015)
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Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP
Kim, Hogyoung, Naura, Amarjit S, Errami, Youssef, Ju, Jihang, Boulares, A Hamid
Published in Molecular medicine (Cambridge, Mass.) (01.09.2011)
Published in Molecular medicine (Cambridge, Mass.) (01.09.2011)
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High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors
Naura, Amarjit S, Hans, Chetan P, Zerfaoui, Mourad, Errami, Youssef, Ju, Jihang, Kim, Hogyoung, Matrougui, Khalid, Kim, Jong G, Boulares, A Hamid
Published in Laboratory investigation (01.11.2009)
Published in Laboratory investigation (01.11.2009)
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PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth
Kim, Hogyoung, Abd Elmageed, Zakaria Y, Ju, Jihang, Naura, Amarjit S, Abdel-Mageed, Asim B, Varughese, Shibu, Paul, Dennis, Alahari, Suresh, Catling, Andrew, Kim, Jong G, Boulares, A Hamid
Published in Molecular medicine (Cambridge, Mass.) (2013)
Published in Molecular medicine (Cambridge, Mass.) (2013)
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ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability
Errami, Youssef, Brim, Hassan, Oumouna-Benachour, Karine, Oumouna, Mustapha, Naura, Amarjit S, Kim, Hogyoung, Ju, Jihang, Davis, Christian J, Kim, Jong G, Ashktorab, Hassan, Fallon, Kenneth, Xu, Ming, Zhang, Jianhua, Del Valle, Luis, Boulares, A Hamid
Published in PloS one (22.02.2013)
Published in PloS one (22.02.2013)
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Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy
Hans, Chetan P, Feng, Yumei, Naura, Amarjit S, Troxclair, Dana, Zerfaoui, Mourad, Siddiqui, Danish, Ju, Jihang, Kim, Hogyoung, Kaye, Alan D, Matrougui, Khalid, Lazartigues, Eric, Boulares, A. Hamid
Published in Cardiovascular pathology (01.03.2011)
Published in Cardiovascular pathology (01.03.2011)
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Organoid Modeling of the Tumor Immune Microenvironment
Neal, James T., Li, Xingnan, Zhu, Junjie, Giangarra, Valeria, Grzeskowiak, Caitlin L., Ju, Jihang, Liu, Iris H., Chiou, Shin-Heng, Salahudeen, Ameen A., Smith, Amber R., Deutsch, Brian C., Liao, Lillian, Zemek, Allison J., Zhao, Fan, Karlsson, Kasper, Schultz, Liora M., Metzner, Thomas J., Nadauld, Lincoln D., Tseng, Yuen-Yi, Alkhairy, Sahar, Oh, Coyin, Keskula, Paula, Mendoza-Villanueva, Daniel, De La Vega, Francisco M., Kunz, Pamela L., Liao, Joseph C., Leppert, John T., Sunwoo, John B., Sabatti, Chiara, Boehm, Jesse S., Hahn, William C., Zheng, Grace X.Y., Davis, Mark M., Kuo, Calvin J.
Published in Cell (13.12.2018)
Published in Cell (13.12.2018)
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Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
Salahudeen, Ameen A., Choi, Shannon S., Rustagi, Arjun, Zhu, Junjie, van Unen, Vincent, de la O, Sean M., Flynn, Ryan A., Margalef-Català, Mar, Santos, António J. M., Ju, Jihang, Batish, Arpit, Usui, Tatsuya, Zheng, Grace X. Y., Edwards, Caitlin E., Wagar, Lisa E., Luca, Vincent, Anchang, Benedict, Nagendran, Monica, Nguyen, Khanh, Hart, Daniel J., Terry, Jessica M., Belgrader, Phillip, Ziraldo, Solongo B., Mikkelsen, Tarjei S., Harbury, Pehr B., Glenn, Jeffrey S., Garcia, K. Christopher, Davis, Mark M., Baric, Ralph S., Sabatti, Chiara, Amieva, Manuel R., Blish, Catherine A., Desai, Tushar J., Kuo, Calvin J.
Published in Nature (London) (24.12.2020)
Published in Nature (London) (24.12.2020)
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Journal Article
NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs
Wen, Zhenke, Shimojima, Yasuhiro, Shirai, Tsuyoshi, Li, Yinyin, Ju, Jihang, Yang, Zhen, Tian, Lu, Goronzy, Jörg J, Weyand, Cornelia M
Published in The Journal of clinical investigation (02.05.2016)
Published in The Journal of clinical investigation (02.05.2016)
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Journal Article
Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis
Li, Yinyin, Shen, Yi, Hohensinner, Philipp, Ju, Jihang, Wen, Zhenke, Goodman, Stuart B., Zhang, Hui, Goronzy, Jörg J., Weyand, Cornelia M.
Published in Immunity (Cambridge, Mass.) (18.10.2016)
Published in Immunity (Cambridge, Mass.) (18.10.2016)
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Journal Article
Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation
Li, Guangjin, Ju, Jihang, Weyand, Cornelia M, Goronzy, Jörg J
Published in The Journal of immunology (1950) (01.08.2015)
Published in The Journal of immunology (1950) (01.08.2015)
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Journal Article
Unconventional activation of PRKDC by TNF-[alpha]: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
Ghonim, Mohamed A, Ju, Jihang, Pyakurel, Kusma, Ibba, Salome V, Abouzeid, Mai M, Rady, Hamada F, Matsuyama, Shigemi, Del Valle, Luis, Boulares, A. Hamid
Published in Journal of inflammation (London, England) (30.04.2024)
Published in Journal of inflammation (London, England) (30.04.2024)
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Journal Article
The catalytic subunit of DNA-PK has a unique function in inflammation independently of Ku70 and DNA repair: a new opportunity to target the enzyme without interfering with DNA repair
Ghonim, Mohamed Ahmed, Pyakurel, Kusma, Luu, Hanh, Okpechi, Samuel, Ju, Jihang, Boulares, Hamid
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation
Zerfaoui, Mourad, Errami, Youssef, Naura, Amarjit S, Suzuki, Yasuhiro, Kim, Hogyoung, Ju, Jihang, Liu, Tao, Hans, Chetan P, Kim, Jong G, Abd Elmageed, Zakaria Y, Koochekpour, Shahriar, Catling, Andrew, Boulares, A Hamid
Published in The Journal of immunology (1950) (01.08.2010)
Published in The Journal of immunology (1950) (01.08.2010)
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Apoptotic DNA Fragmentation May Be a Cooperative Activity between Caspase-activated Deoxyribonuclease and the Poly(ADP-ribose) Polymerase-regulated DNAS1L3, an Endoplasmic Reticulum-localized Endonuclease That Translocates to the Nucleus during Apoptosis
Errami, Youssef, Naura, Amarjit S., Kim, Hogyoung, Ju, Jihang, Suzuki, Yasuhiro, El-Bahrawy, Ali H., Ghonim, Mohamed A., Hemeida, Ramadan A., Mansy, Moselhy S., Zhang, Jianhua, Xu, Ming, Smulson, Mark E., Brim, Hassan, Boulares, A. Hamid
Published in The Journal of biological chemistry (01.02.2013)
Published in The Journal of biological chemistry (01.02.2013)
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DNA-dependent protein kinase plays a role in inflammation independent of DNA-damage repair function and its inhibition blocks allergic inflammation in mice and modulates human CD4+ T cell function without causing SCID (HYP7P.264)
Pyakurel, Kusma, Ghonim, Mohamed, Ju, Jihang, Rodriguez, Paulo, Lammi, Matthew, Davis, Christian, Naura, Amarjit, Boulares, Hamid
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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Journal Article
NADPH oxidase deficiency underlies dysfunction of aged CD8^sup +^ Tregs
Wen, Zhenke, Shimojima, Yasuhiro, Shirai, Tsuyoshi, Li, Yinyin, Ju, Jihang, Yang, Zhen, Tian, Lu, Goronzy, Jörg J, Weyand, Cornelia M
Published in The Journal of clinical investigation (01.05.2016)
Published in The Journal of clinical investigation (01.05.2016)
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Journal Article