Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection
Kester, Kent E., Cummings, James F., Ofori-Anyinam, Opokua, Ockenhouse, Christian F., Krzych, Urszula, Moris, Philippe, Schwenk, Robert, Nielsen, Robin A., Debebe, Zufan, Pinelis, Evgeny, Juompan, Laure, Williams, Jack, Dowler, Megan, Stewart, V. Ann, Wirtz, Robert A., Dubois, Marie-Claude, Lievens, Marc, Cohen, Joe, Ballou, W. Ripley, Heppner, D. Gray
Published in The Journal of infectious diseases (01.08.2009)
Published in The Journal of infectious diseases (01.08.2009)
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RANDOMIZED, CONTROLLED, DOUBLE-BLIND TRIAL OF DAILY ORAL AZITHROMYCIN IN ADULTS FOR THE PROPHYLAXIS OF PLASMODIUM VIVAX MALARIA IN WESTERN THAILAND
HEPPNER, D. GRAY, JR, WALSH, DOUGLAS S, UTHAIMONGKOL, NICHAPAT, TANG, DOUGLAS B, TULYAYON, SOMCHIT, PERMPANICH, BARNYEN, WIMONWATTRAWATEE, THEERA, CHUANAK, NIPHON, LAOBOONCHAI, ANINTITA, SOOKTO, PRASIT, BREWER, THOMAS G, MCDANIEL, PHILIP, EAMSILA, CHIRAPA, YONGVANITCHIT, KOSOL, UHL, KATHLEEN, KYLE, DENNIS E, KEEP, LISA W, MILLER, ROBERT E, WONGSRICHANALAI, CHANSUDA
Published in The American journal of tropical medicine and hygiene (01.11.2005)
Published in The American journal of tropical medicine and hygiene (01.11.2005)
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Journal Article
Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine
Vahey, Maryanne T., Wang, Zhining, Kester, Kent E., Cummings, James, Heppner, D. Gray, Nau, Martin E., Ofori-Anyinam, Opokua, Cohen, Joe, Coche, Thierry, Ballou, W. Ripley, Ockenhouse, Christian F.
Published in The Journal of infectious diseases (15.02.2010)
Published in The Journal of infectious diseases (15.02.2010)
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Journal Article
Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection
Cummings, James F, Spring, Michele D, Schwenk, Robert J, Ockenhouse, Christian F, Kester, Kent E, Polhemus, Mark E, Walsh, Douglas S, Yoon, In-Kyu, Prosperi, Christine, Juompan, Laure Y, Lanar, David E, Krzych, Urszula, Hall, B. Ted, Ware, Lisa A, Stewart, V. Ann, Williams, Jack, Dowler, Megan, Nielsen, Robin K, Hillier, Collette J, Giersing, Birgitte K, Dubovsky, Filip, Malkin, Elissa, Tucker, Kathryn, Dubois, Marie-Claude, Cohen, Joe D, Ballou, W. Ripley, Jr, D. Gray Heppner
Published in Vaccine (12.07.2010)
Published in Vaccine (12.07.2010)
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A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults
Kester, Kent E, McKinney, Denise A, Tornieporth, Nadia, Ockenhouse, Christian F, Heppner, D. Gray, Hall, Ted, Wellde, Bruce T, White, Kate, Sun, Peifang, Schwenk, Robert, Krzych, Urszula, Delchambre, Martine, Voss, Gerald, Dubois, Marie-Claude, Gasser, Robert A, Dowler, Megan G, O’Brien, Megan, Wittes, Janet, Wirtz, Robert, Cohen, Joe, Ballou, W. Ripley
Published in Vaccine (20.07.2007)
Published in Vaccine (20.07.2007)
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Journal Article
Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to That with Either Malaria Vaccine Alone
STEWART, V. Ann, MCGRATH, Shannon M, DEMOITIE, Marie-Ange, JAN WEVERLING, Gerrit, BAYAT, Babak, CUSTERS, Jerome H. H. V, DUBOIS, Marie-Claude, COHEN, Joe, GOUDSMIT, Jaap, GRAY HEPPNER, D, DUBOIS, Patrice M, PAU, Maria G, METTENS, Pascal, SHOTT, Joseph, COBB, Michelle, BURGE, J. Robert, LARSON, David, WARE, Lisa A
Published in Infection and Immunity (01.05.2007)
Published in Infection and Immunity (01.05.2007)
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Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research
Polhemus, Mark E, Magill, Alan J, Cummings, James F, Kester, Kent E, Ockenhouse, Chris F, Lanar, David E, Dutta, Sheetij, Barbosa, Arnoldo, Soisson, Lorraine, Diggs, Carter L, Robinson, Sally A, Haynes, John D, Stewart, V. Ann, Ware, Lisa A, Brando, Clara, Krzych, Urszula, Bowden, Robert A, Cohen, Joe D, Dubois, Marie-Claude, Ofori-Anyinam, Opokua, De-Kock, Els, Ballou, W. Ripley, Heppner, D. Gray
Published in Vaccine (22.05.2007)
Published in Vaccine (22.05.2007)
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Randomized Trial of 3-Dose Regimens of Tafenoquine (WR238605) versus Low-Dose Primaquine for Preventing Plasmodium vivax Malaria Relapse
Walsh, Douglas S., Wilairatana, Polrat, Tang, Douglas B., Heppner, D. Gray, Brewer, Thomas G., Krudsood, Srivicha, Silachamroon, Udomsak, Phumratanaprapin, Weerapong, Siriyanonda, Duangsuda, Looareesuwan, Sornchai
Published in Clinical infectious diseases (15.10.2004)
Published in Clinical infectious diseases (15.10.2004)
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Journal Article
PHASE 1 SAFETY AND IMMUNOGENICITY TRIAL OF MALARIA VACCINE RTS,S/AS02A IN ADULTS IN A HYPERENDEMIC REGION OF WESTERN KENYA
STOUTE, JOSE A, HEPPNER, D. GRAY, JR, MASON, CARL J, SIANGLA, JORAM, OPOLLO, MALACHI O, KESTER, KENT E, VIGNERON, LAURENCE, VOSS, GERALD, WALTER, MICHAEL J, TORNIEPORTH, NADIA, COHEN, JOE D, BALLOU, W. RIPLEY
Published in The American journal of tropical medicine and hygiene (01.07.2006)
Published in The American journal of tropical medicine and hygiene (01.07.2006)
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Journal Article
Malaria Treatment with Atovaquone-Proguanil in Malaria-Immune Adults: Implications for Malaria Intervention Trials and for Pre-Exposure Prophylaxis of Malaria
POLHEMUS, Mark E, REMICH, Shon, OGUTU, Bernhards, WAITUMBI, John, LIEVENS, Marc, RIPLEY BALLOU, W, HEPPNER, D. Gray
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
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Activation of Innate Immunity in Healthy Macaca mulatta Macaques by a Single Subcutaneous Dose of GMP CpG 7909: Safety Data and Interferon-Inducible Protein-10 Kinetics for Humans and Macaques
Stewart, V Ann, McGrath, Shannon, Krieg, Arthur M, Larson, Noelle S, Angov, Evelina, Smith, Christopher L, Brewer, Thomas G, Heppner, Jr, D Gray
Published in Clinical and Vaccine Immunology (01.02.2008)
Published in Clinical and Vaccine Immunology (01.02.2008)
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Journal Article
SAFETY AND IMMUNOGENICITY OF RTS,S+TRAP MALARIA VACCINE, FORMULATED IN THE AS02A ADJUVANT SYSTEM, IN INFANT RHESUS MONKEYS
WALSH, DOUGLAS S, PICHYANGKUL, SATHIT, GETTAYACAMIN, MONTIP, TONGTAWE, PONGSRI, SIEGRIST, CLAIRE-ANNE, HANSUKJARIYA, PRANEE, KESTER, KENT E, HOLLAND, CAROLYN A, VOSS, GERALD, COHEN, JOE, STEWART, ANN V, MILLER, R. SCOTT, BALLOU, W. RIPLEY, HEPPNER, D. GRAY, JR
Published in The American journal of tropical medicine and hygiene (01.05.2004)
Published in The American journal of tropical medicine and hygiene (01.05.2004)
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Journal Article
A Field Trial to Assess a Blood-Stage Malaria Vaccine
Thera, Mahamadou A, Doumbo, Ogobara K, Coulibaly, Drissa, Laurens, Matthew B, Ouattara, Amed, Kone, Abdoulaye K, Guindo, Ando B, Traore, Karim, Traore, Idrissa, Kouriba, Bourema, Diallo, Dapa A, Diarra, Issa, Daou, Modibo, Dolo, Amagana, Tolo, Youssouf, Sissoko, Mady, Sissoko, Mahamadou S, Niangaly, Amadou, Takala-Harrison, Shannon, Lyke, Kirsten E, Wu, Yukun, Blackwelder, William C, Godeaux, Olivier, Vekemans, Johan, Dubois, Marie-Claude, Ballou, W. Ripley, Cohen, Joe, Thompson, Darby, Dube, Tina, Soisson, Lorraine, Diggs, Carter L, House, Brent, Lanar, David E, Dutta, Sheetij, Heppner, D. Gray, Plowe, Christopher V
Published in The New England journal of medicine (15.09.2011)
Published in The New England journal of medicine (15.09.2011)
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Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study
Heppner, D Gray, Dr, Kemp, Tracy L, MPH, Martin, Brian K, PhD, Ramsey, William J, MD, Nichols, Richard, MA, Dasen, Emily J, BA, Link, Charles J, MD, Das, Rituparna, MD, Xu, Zhi Jin, PhD, Sheldon, Eric A, MD, Nowak, Teresa A, BSE, Monath, Thomas P, MD
Published in The Lancet infectious diseases (01.08.2017)
Published in The Lancet infectious diseases (01.08.2017)
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Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
Spring, Michele D, Cummings, James F, Ockenhouse, Christian F, Dutta, Sheetij, Reidler, Randall, Angov, Evelina, Bergmann-Leitner, Elke, Stewart, V Ann, Bittner, Stacey, Juompan, Laure, Kortepeter, Mark G, Nielsen, Robin, Krzych, Urszula, Tierney, Ev, Ware, Lisa A, Dowler, Megan, Hermsen, Cornelus C, Sauerwein, Robert W, de Vlas, Sake J, Ofori-Anyinam, Opokua, Lanar, David E, Williams, Jack L, Kester, Kent E, Tucker, Kathryn, Shi, Meng, Malkin, Elissa, Long, Carole, Diggs, Carter L, Soisson, Lorraine, Dubois, Marie-Claude, Ballou, W Ripley, Cohen, Joe, Heppner, Jr, D Gray
Published in PloS one (23.04.2009)
Published in PloS one (23.04.2009)
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Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults
Kester, Kent E, Gray Heppner, D, Moris, Philippe, Ofori-Anyinam, Opokua, Krzych, Urszula, Tornieporth, Nadia, McKinney, Denise, Delchambre, Martine, Ockenhouse, Christian F, Voss, Gerald, Holland, Carolyn, Beckey, Jolie Palensky, Ballou, W. Ripley, Cohen, Joe
Published in Vaccine (20.11.2014)
Published in Vaccine (20.11.2014)
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Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area
Polhemus, Mark E, Remich, Shon A, Ogutu, Bernhards R, Waitumbi, John N, Otieno, Lucas, Apollo, Stella, Cummings, James F, Kester, Kent E, Ockenhouse, Christian F, Stewart, Ann, Ofori-Anyinam, Opokua, Ramboer, Isabelle, Cahill, Conor P, Lievens, Marc, Dubois, Marie-Claude, Demoitie, Marie-Ange, Leach, Amanda, Cohen, Joe, Ballou, W Ripley, Heppner, Jr, D Gray
Published in PloS one (31.07.2009)
Published in PloS one (31.07.2009)
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Journal Article
Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research
Kester, Kent E, Cummings, James F, Ockenhouse, Christian F, Nielsen, Robin, Hall, B. Ted, Gordon, Daniel M, Schwenk, Robert J, Krzych, Urszula, Holland, Carolyn A, Richmond, Gregory, Dowler, Megan G, Williams, Jackie, Wirtz, Robert A, Tornieporth, Nadia, Vigneron, Laurence, Delchambre, Martine, Demoitie, Marie-Ange, Ballou, W. Ripley, Cohen, Joe, Heppner, D. Gray
Published in Vaccine (24.04.2008)
Published in Vaccine (24.04.2008)
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Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen
Mettens, Pascal, Dubois, Patrice M, Demoitié, Marie-Ange, Bayat, Babak, Donner, Marie-Noëlle, Bourguignon, Patricia, Stewart, V. Ann, Heppner, D. Gray, Garçon, Nathalie, Cohen, Joe
Published in Vaccine (20.02.2008)
Published in Vaccine (20.02.2008)
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