Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G
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Published in Journal of medicinal chemistry (28.07.2005)
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Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
Rigat, Karen L., Lu, Hao, Wang, Ying-Kai, Argyrou, Argyrides, Fanslau, Caroline, Beno, Brett, Wang, Yi, Marcinkeviciene, Jovita, Ding, Min, Gentles, Robert G., Gao, Min, Abell, Lynn M., Roberts, Susan B.
Published in The Journal of biological chemistry (28.11.2014)
Published in The Journal of biological chemistry (28.11.2014)
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Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation
Metzler, William J., Yanchunas, Joseph, Weigelt, Carolyn, Kish, Kevin, Klei, Herbert E., Xie, Dianlin, Zhang, Yaqun, Corbett, Martin, Tamura, James K., He, Bin, Hamann, Lawrence G., Kirby, Mark S., Marcinkeviciene, Jovita
Published in Protein science (01.02.2008)
Published in Protein science (01.02.2008)
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Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors
Zhao, Guohua, Kwon, Chet, Wang, Aiying, Robertson, James G., Marcinkeviciene, Jovita, Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1
Marcin, Lawrence R., Higgins, Mendi A., Zusi, F. Christopher, Zhang, Yunhui, Dee, Michael F., Parker, Michael F., Muckelbauer, Jodi K., Camac, Daniel M., Morin, Paul E., Ramamurthy, Vidhyashankar, Tebben, Andrew J., Lentz, Kimberley A., Grace, James E., Marcinkeviciene, Jovita A., Kopcho, Lisa M., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Meredith, Jere E., Albright, Charles F., Bronson, Joanne J., Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase
HAQUE, Tasir S., TADESSE, Seifu, MARCINKEVICIENE, Jovita, ROGERS, M. John, SIZEMORE, Christine, KOPCHO, Lisa M., AMSLER, Karen, ECRET, Lisa D., ZHAN, Dong Liang, HOBBS, Frank, SLEE, Andrew, TRAINOR, George L., STERN, Andrew M., COPELAND, Robert A., COMBS, Andrew P.
Published in Journal of medicinal chemistry (10.10.2002)
Published in Journal of medicinal chemistry (10.10.2002)
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Evidence for Isoniazid Oxidation by Oxyferrous Mycobacterial Catalase−Peroxidase
Magliozzo, Richard S, Marcinkeviciene, Jovita A
Published in Journal of the American Chemical Society (13.11.1996)
Published in Journal of the American Chemical Society (13.11.1996)
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Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties
Wilson, Theresa, de Lisle, Geoffrey W, Marcinkeviciene, Jovita A, Blanchardand, John S, Collins, Desmond M
Published in Microbiology (Society for General Microbiology) (01.10.1998)
Published in Microbiology (Society for General Microbiology) (01.10.1998)
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Helicobacter pylori-selective Antibacterials Based on Inhibition of Pyrimidine Biosynthesis
Copeland, Robert A., Marcinkeviciene, Jovita, Haque, Tasir S., Kopcho, Lisa M., Jiang, Wenjun, Wang, Kathy, Ecret, Lisa D., Sizemore, Christine, Amsler, Karen A., Foster, Lori, Tadesse, Seifu, Combs, Andrew P., Stern, Andrew M., Trainor, George L., Slee, Andrew, Rogers, M. John, Hobbs, Frank
Published in The Journal of biological chemistry (27.10.2000)
Published in The Journal of biological chemistry (27.10.2000)
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Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones
Marcinkeviciene, Jovita, Rogers, M.John, Kopcho, Lisa, Jiang, Wenjun, Wang, Kathy, Murphy, Dennis J, Lippy, Jonathan, Link, Steven, Chung, Thomas D.Y, Hobbs, Frank, Haque, Tasir, Trainor, George L, Slee, Andrew, Stern, Andrew M, Copeland, Robert A
Published in Biochemical pharmacology (01.08.2000)
Published in Biochemical pharmacology (01.08.2000)
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Novel Inhibition of Porcine Pepsin by a Substituted Piperidine
Marcinkeviciene, Jovita, Kopcho, Lisa M., Yang, Tao, Copeland, Robert A., Glass, Brian M., Combs, Andrew P., Falahatpisheh, Nikoo, Thompson, Lorin
Published in The Journal of biological chemistry (09.08.2002)
Published in The Journal of biological chemistry (09.08.2002)
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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors
Regard, Jean B., Harrison, Tyler J., Axford, Jake, Axford, Laura, Lee, Lac, Ren, Xianglin, Deng, Lin, Reynolds, Aimee, Mao, Justin, Liu, Qian, Patnaik, Anup, Cohick, Evan, Hollis-Symynkywicz, Micah, Loi, Sally, Riek, Simone, McKeever, Una, Dunstan, David, Sung, MooJe, Ware, Nathaniel F., Brown, Alan P., Hamann, Lawrence G., Marcinkeviciene, Jovita, Patterson, Andrew W., Marro, Martin L.
Published in Biochemical pharmacology (01.03.2023)
Published in Biochemical pharmacology (01.03.2023)
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Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO)
Patnaik, Anup, Axford, Laura, Deng, Lin, Cohick, Evan, Ren, Xianglin, Loi, Sally, Kecman, Sam, Hollis-Symynkywicz, Micah, Harrison, Tyler J., Papillon, Julien P.N., Dales, Natalie, Hamann, Lawrence G., Lee, Lac, Regard, Jean B., Marcinkeviciene, Jovita, Marro, Martin L., Patterson, Andrew W.
Published in Bioorganic & medicinal chemistry (15.06.2020)
Published in Bioorganic & medicinal chemistry (15.06.2020)
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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O'Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Jr, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor
Marro, Martin L, Patterson, Andrew W, Lee, Lac, Deng, Lin, Reynolds, Aimee, Ren, Xianglin, Axford, Laura, Patnaik, Anup, Hollis-Symynkywicz, Micah, Casson, Nigel, Custeau, Dominique, Ames, Lisa, Loi, Sally, Zhang, Lihe, Honda, Toshiyuki, Blank, Jutta, Harrison, Tyler J, Papillon, Julien P N, Hamann, Lawrence G, Marcinkeviciene, Jovita, Regard, Jean B
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
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