Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A(2A) Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease
Zhang, Xiaohu, Tellew, John E., Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Williams, John P., Saunders, John, Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Wen, Jenny, Jalali, Kayvon, O'Brien, Zhihong, Stotz, Carol E., Crespo, Maria I., Diaz, Jose-Luis, Slee, Deborah H.
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Journal Article
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A(2A) receptor antagonists with in vivo efficacy
Slee, Deborah H., Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Wen, Jenny, O'Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A(2A) Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy
Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, Maria I., Diaz, Jose-Luis, Saunders, John, Wen, Jenny, O'Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.
Published in Journal of medicinal chemistry (12.02.2009)
Published in Journal of medicinal chemistry (12.02.2009)
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Journal Article
N -[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A 2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy
Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I., Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.
Published in Journal of medicinal chemistry (12.02.2009)
Published in Journal of medicinal chemistry (12.02.2009)
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Journal Article
Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease
Zhang, Xiaohu, Tellew, John E, Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Williams, John P, Saunders, John, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E, Crespo, María I, Díaz, José-Luis, Slee, Deborah H
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Journal Article
Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy
Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
2-amino-N-pyrimidin-4-ylacetamides as A(2A) receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships
Slee, Deborah H., Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Samos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O'Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships
Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists
XIAOHU ZHANG, RUETER, Jaimie K, MARKISON, Stacy, JOSWIG, Tanya, MALANY, Siobhan, SANTOS, Mark, CASTRO-PALOMINO, Julio C, CRESPO, Maria I, PRAT, Maria, GUAL, Silvia, DIAZ, José-Luis, SAUNDERS, John, YONGSHENG CHEN, SLEE, Deborah H, MOORJANI, Manisha, LANIER, Marion C, LIN, Emily, GROSS, Raymond S, TELLEW, John E, WILLIAMS, John P, LECHNER, Sandra M
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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Journal Article
N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2AReceptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy
LANIER, Marion C, MOORJANI, Manisha, MARKISON, Stacy, JOSWIG, Tanya, KARGO, William, PIERCEY, Jaime, SANTOS, Mark, MALANY, Siobhan, ZHAO, Marilyn, PETROSKI, Robert, CRESPO, Maria I, DIAZ, Jose-Luis, ZHIYONG LUO, SAUNDERS, John, WEN, Jenny, O'BRIEN, Zhihong, JALALI, Kayvon, MADAN, Ajay, SLEE, Deborah H, YONGSHENG CHEN, LIN, Emily, TELLEW, John E, XIAOHU ZHANG, WILLIAMS, John P, GROSS, Raymond S, LECHNER, Sandra M
Published in Journal of medicinal chemistry (2009)
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Published in Journal of medicinal chemistry (2009)
Journal Article
Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A 2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease
Zhang, Xiaohu, Tellew, John E., Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Williams, John P., Saunders, John, Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E., Crespo, María I., Díaz, José-Luis, Slee, Deborah H.
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
Get full text
Journal Article
N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy
Lanier, Marion C, Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E, Zhang, Xiaohu, Williams, John P, Gross, Raymond S, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I, Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H
Published in Journal of medicinal chemistry (12.02.2009)
Published in Journal of medicinal chemistry (12.02.2009)
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Journal Article
2-Amino- N -pyrimidin-4-ylacetamides as A 2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships
Slee, Deborah H., Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, María I., Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (01.03.2008)
Published in Journal of medicinal chemistry (01.03.2008)
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Journal Article
Identification of Novel, Water-Soluble, 2-Amino- N -pyrimidin-4-yl Acetamides as A 2A Receptor Antagonists with In Vivo Efficacy
Slee, Deborah H., Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, María I., Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (01.02.2008)
Published in Journal of medicinal chemistry (01.02.2008)
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Journal Article
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A sub(2A) receptor antagonists
Zhang, Xiaohu, Rueter, Jaimie K, Chen, Yongsheng, Moorjani, Manisha, Lanier, Marion C, Lin, Emily, Gross, Raymond S, Tellew, John E, Williams, John P, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Malany, Siobhan, Santos, Mark, Castro-Palomino, Julio C, Crespo, Mari'a I, Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Saunders, John, Slee, Deborah H
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A 2A receptor antagonists
Zhang, Xiaohu, Rueter, Jaimie K., Chen, Yongsheng, Moorjani, Manisha, Lanier, Marion C., Lin, Emily, Gross, Raymond S., Tellew, John E., Williams, John P., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Malany, Siobhan, Santos, Mark, Castro-Palomino, Julio C., Crespo, Marı´a I., Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John, Slee, Deborah H.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Journal Article